I am a serious runner (1200 miles per year) and over the years have collected different water bottles and carriers, which I stopped using for various reasons and just started carrying a cold drink by hand. Then I saw someone running with the Nathan Quickdraw and bought one at my local running store (though the price on Amazon is much less--I just needed it right away). Here is why I am very happy with it.
1. It is much easier to run with a bottle using this carrier because you no longer have to hold it tight, and also don't have a cold bottle in the palm of your hand (which not only can be uncomfortable, but also warms the bottle up with your body heat).
2. There is an easy to use adjustable strap that goes across the back of your hand, and a mesh palm piece that keeps your hand off the bottle. This entire unit is well constructed and well stitched.
3. The included 22 oz. bottle is not insulated, which means that in really warm weather your cold drink will become warm quickly, even if you start out with it frozen. However, I solved that problem by placing the bottle in the Built NY 20 oz neoprene sleeve (which I have reviewed on Amazon), so now I have an insulated water bottle. Realistically you will only put 20 oz into the included bottle because that fills it to just about 1/4 inch from the top.
4. This has a small zippered pocket which you can use for various things, such as car keys, money, gel etc. If you need to carry your cell phone (I carry my BlackBerry), I recommend the Spibelt (which I have reviewed on Amazon).
5. The bottle is easy to fill, more than wide enough for ice cubes, and has an easy to use spout. I did not experience any leakage at all while running, unlike with some other water bottles. You can also use your own water bottle if you prefer.
Bottom line: I really like this carrier, and prefer it to having something around my waist or over my shoulder. However, everyone has different preferences, so you need to try different things to see what works best for you.
Update June 4, 2011: I now use the Smart Source stainless steel water bottle (which I have reviewed on Amazon) instead of the included bottle. The Smart Source holds 27 oz. rather than 22 oz., comes with its own neoprene sleeve for insulation, and nicely fits into the Quickdraw.
Update August 11, 2011: When I run at night, I clip a flashing light to the top strap of this holder. Even with the water bottle in it, there is room to do so.
Update April 5, 2012: Although this product works just fine, over the last couple of months I started using the Eastern Mountain Sports Espresso waist pack. It is much bulkier, though I really do not notice it when I have it on. Besides carrying my water bottle, there are two mesh pockets (one I use for my iPhone, and the other for cash, gel, etc.). I usually don't like waist packs for running, but this one feels different. Something to consider if you don't want to carry your water bottle in your hand.