BioEntopic Lidocaine Crème is a combination of 5% Lidocaine USP with bio-available herbal extracts of Feverfew and Jamaican Dogwood. At an annual meeting of the American Society for Clinical Pharmacology, Dr. Freitag presented research of a placebo-controlled trial of 40 migraine patients. Of those patients using lidocaine, seven were pain-free in 2 hours and eight were pain free in 8 hours compared to none in the placebo-treated group. There were no significant side affects. Lidocaine cream could be used on its own or as an adjunct to other medication, Dr. Freitag noted. "When patients get a migraine attack, it takes a while for normal oral medication to work, while this provides relief very quickly." He added, "We foresee people using it primarily as a mainstay of therapy."