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  • Nature Made SAM-e Complete 400mg, 36 Tablets
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Nature Made SAM-e Complete 400mg, 36 Tablets

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  • Pack of 36, double strength, mood-balancing, 400 milligram SAM-e tablets
  • Clinically proven to help with mood support, joint comfort and liver health
  • Replenishes chemicals that affect mood; contains 400 mg of SAM-e per serving tablet
  • Relieves joint pain; repairs joint cartilage
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Nature Made SAM-e Complete 400mg, 36 Tablets + Natrol 5-HTP TR Time Release, 200mg, 30 Tablets
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Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Please see our full disclaimer below.

Product Description

Size: 36

Product Description

Dietary Supplement. S-Adenosylmethionine. Clinically Proven: Mood Support; Joint Comfort; Liver Health. Sam-E (S-Adenosylmethionine) is a naturally occurring compound found in all living organisms. In humans, Sam-E is distributed throughout the body and is involved in may biochemical processes. Since significant amount of Sam-E are not available through diet alone, the body is primarily responsible for producing its own Sam-e. Scientists know that Sam-e declines as people age and that certain groups of people, including those with low mood and liver conditions, tend to have lower levels of Sam-E in their bodies. Over 100 clinical studies involving thousands of people have proven that Sam-E supplementation benefits a multitude of body functions including: Mood Support - Enhances mood by promoting a healthy balance of neurotransmitters, dopamine and serotonin, which are part of overall healthy brain cell functions. Joint Comfort - Promotes joint health by helping to maintain joint cartridge which naturally deteriorates with physical activity and age. Liver Health - Helps support detoxification and overall healthy liver functions. MoodPlus Sam-E is the same form of Sam-E available and administered for over 20 years by doctors in Europe. It is the only form of Sam-E studied in over two decades of research, as well as the most documented form in respected medical journals. Short and long-term studies have proven that Sam-E is a safe, non-toxic and efficacious product to support your health. Sam-E Tablets made to Nature Made's guaranteed purity and potency standards. Made in Italy. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.)


Feeling moody or out of sorts? Start to feel like yourself again with Nature Made SAM-e Complete. Clinically proven to help support healthy moods and joint comfort, SAM-e, or S-adenosylmethionine, is a naturally occurring molecule produced by your body. Various factors, like diet or aging, can cause SAM-e levels to deplete, which may negatively affect your mood. Adding an SAM-e supplement to your diet can begin naturally restoring a healthy mood in as little as 7 to 14 days.

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Nature Made SAM-e Complete
At a Glance:
  • Supports healthy moods and joint comfort by balancing brain cell functions

  • Yields positive results in 7 to 14 days

  • No artificial flavors or preservatives

  • Yeast and gluten free

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Nature Made SAM-e Complete (36 tablets, 400 mg/each) Product Shot

Contains no artificial flavors, preservatives, yeast, or gluten.
Nature Made SAM-e Complete (36 tablets, 400 mg/each) Product Shot

Help support healthy moods and joint comfort with SAM-E. View larger.
How SAM-e Works
SAM-e naturally restores a healthy mood by promoting a balance of brain cell functions. The SAM-e molecule is responsible for over 100 reactions in the body, including making neural transmitters and proteins, and acts as a master switch to keep cells working properly. People who are feeling out of sorts or moody generally have a depleted level of SAM-e.

Supports Healthy Mood and Joint Comfort
Though SAM-e is manufactured in most cells of the body, there are no direct dietary sources for the enzyme. Diet and aging are two of the factors that may lead to decreased levels of SAM-e in the body, which can cause joint pain and altered moods. Supplementing your diet with Nature Made SAM-e Complete has been clinically proven to yield positive results in 7 to 14 days.

Natural Ingredients for a Healthy Supplement
SAM-e Complete is made to Nature Made's purity and potency standards. This product contains no artificial flavors, preservatives, yeast, or gluten.

About Nature Made: A Commitment to Great Vitamins
Nature Made is committed to making the highest quality vitamins and supplements possible. Their products are designed to be science-based, safe, and effective for your health and wellness needs. Before a vitamin or supplement is produced for public consumption, it has passed through a rigorous evaluation process. From ingredient purity to manufacturing excellence, Nature Made products are independently certified for quality, purity, strength and consistency, giving you peace of mind that you can trust what you're putting into your body.

What's in the Box
Nature Made SAM-e Complete (36 tablets, 400 mg/each).

Product Details

Size: 36
  • Product Dimensions: 2.2 x 3.1 x 5.1 inches ; 2.7 ounces
  • Shipping Weight: 3.2 ounces (View shipping rates and policies)
  • Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
  • Origin: USA
  • ASIN: B0002D150Y
  • UPC: 031604411077 885285025296
  • Item model number: 1107Z
  • Average Customer Review: 4.1 out of 5 stars  See all reviews (210 customer reviews)
  • Amazon Best Sellers Rank: #6,718 in Health & Personal Care (See Top 100 in Health & Personal Care)
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Customer Reviews

Has really helped with my depression, I feel like myself again!
Over all this is an amazing product and I have been telling everyone I know about it.
J. Musser
They really seem to be helping improve my mood and my mental clarity.

Most Helpful Customer Reviews

712 of 729 people found the following review helpful By Pwoink on November 9, 2009
Size Name: 36
Sam-E has worked well for me, after I knew how to take it properly that is. I took it for about 2 weeks before I actually did some reading about it and knew I was doing many things wrong. Including making the wrong purchase. Any brand will probably do, (as long as it is made properly, see #2 below) but I have found Nature Made to be the best selection when it came to purchasing Sam-E. (Yes, I have actually bought and tried the 200mg AND 400mg tablets) No matter what brand you buy, you have to give it TIME to work. 7-10 days is the timeframe that it will typically start to work in, but I have heard of occasions where it has taken longer. After 12 days if you have seen no positive change in mood, up the dose. Eventually, work your way up to taking 1200mg of Sam-E daily for best results.

Yes, these 400mg tablets ARE enteric coated, which you definitely want in your Sam-E supplement...more on this later.

Stomach Cramps and even the possibility of ulcers be a serious problem for people taking Sam-E. I have compiled a list of precautions and things you can do to prevent this:

1) Make sure you take this product on an EMPTY STOMACH. An empty stomach means not having eaten anything for roughly an hour. The best time to take this is in the morning, right after waking up. Finally, make sure you do not eat for at least 30 MINUTES after taking Sam-e. More time may be required as you take more of the supplement.

2) Do NOT purchase Sam-E tablets that are not enteric coated and are not in a box/blister wrap. The Entric coating prevents the pills from being absorbed by your body until they reach the lower intestine which will prevent a majority of stomach cramps and stomach pains.
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347 of 368 people found the following review helpful By Sandra on November 21, 2011
Size Name: 36
I read all the reviews here before trying the Sam-e. And gave it a try because of Menopause mood issues. I wanted to try something natural. I tried lexepro and it was way too strong, even in the smallest amounts turned me into a zombie, with no emotions.

I took all the advise given, in order to take Sam-e without stomach problems. I bought the right kind (eneric coated in individually sealed package). I took it on an empty stomach with a glass of water. And ate 1/2 hour to hour afterward.

After a few days of taking Sam-e I got the worse stomach pain ever. I could barely move. I had to lay there and force myself to breath. The pain was so bad. I stopped taking Sam-e. It took about 4-5 days to feel better. It hurt every time I ate the smallest amount.

As far as mood, I couldn't take it long enough to see a difference.

A month later after more research, and found that MOST ALL Sam-e products are made with Mannitol, which is a sugar alcohol and this ingredient can cause stomach pain.

So, I decided to try again. This time I bought the GNC eneric coated, individually sealed Sam-e. This brand has NO MANNITOL. I have been taking 200 mg for the past 15 days with no stomach problems. I drink it first thing in the morning on an empty stomach. I wash it down with LOTS of water, probably 24 oz, to make sure it goes way down. And then I eat breakfast 30 - 60 minutes later. AND I HAVE HAD NO PROBLEMS WITH STOMACH PAIN. After about 12 days, I began noticing a wonderful change in my mood. I wake up feeling good. And feel good throughout the day. I just overall feel so much better. So far, I haven't had any unwelcome side effects. Im sleeping well at night, no anxiety or ill effects.

I dont drink Caffeine. Im very sensitive to stimulants, as it makes me feel nervous, it always has. Sam-e has not given me that type of feeling, at all.

Hope this helps someone.
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145 of 154 people found the following review helpful By Ann E. Blair on May 28, 2009
Size Name: 36
I started taking Sam-e over a month ago and I love it! Before starting it I was experiencing anxiety and panic attacks coupled with mood swings. I started keeping track of my mood and realized that I was having more bad days than good. Even little things would upset me and it was like once something happened (no matter how small) it just ruined my mood sometimes for a few hours and sometimes for the rest of the day. I ordered my Sam-e from wholehealth.com because they include a free bottle of Vitamin B Complex with each order. Sam-e can cause a build up of homocysteine in your system which is correlated with heart disease. The B Complex prevents homocysteine build up. I'm currently taking 400 mg a day. It started working quickly and I've experienced no side effects. I've been taking it for over a month and I just have a general sense of well being. I feel happier and I'm not having panic attacks anymore. I've taken Paxil in the past and this is less expensive and without the side effects. [...]. Read up on the benefits of taking a B Complex with it. It's worth mentioning that B Complex contains Vitamin B2 also called Riboflavin. When you take a Vitamin B supplement your body uses what it needs and if it's more than it needs the remainder of the B vitamin is excreted in your urine causing the urine to be very bright yellow. I strongly recommend Sam-e. It really has changed my life. Yes, seriously.
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92 of 102 people found the following review helpful By J. Musser on April 2, 2009
Size Name: 36
Late last year I came across an article for combating arthritis with natural supplements, sam-e being one of them. Having been diagnosed in 2007 with spinal arthritis at the age of 28, I was desperate to find something that worked. I began doing research on sam-e and it's properties and the more I read the more I was ready to try it. In early February of this year I began taking 400 mg a day and by the end of the week I could already tell a difference. By the end of the second week I was amazed at how well I felt. I went from being in constant pain to the occasional twinge here and there. Its been two months and these have been the best two months I've had since being diagnosed. I HIGHLY recommend this supplement.

Info: When taking sam-e its good to take b-vitamins as well, they help aid the sam-e in working. Take it on an empty stomach, about 30-40 minutes before breakfast. If you don't have time to eat or miss breakfast then take heartburn medication within a couple of hours, sam-e can cause painful heartburn if its allowed to release in your stomach instead of your colon. It may be necessary to increase your dose after a few weeks, as well, as you can plateau. If you are bi-polar or suspect you may be, then DO NOT take sam-e until you have spoken with your doctor first. Sam-e can cause some people with bi-polar disorder to go into a manic phase.

Over all this is an amazing product and I have been telling everyone I know about it. Google sam-e and you will find links to studies that outline the other benefits and possible benefits of sam-e. The biggest pitfall is the price, and while yes its expensive you can watch out for sales and buy in bulk, because it really is worth it if you are suffering from chronic pain as I did.
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Most Recent Customer Reviews

Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.