In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. Since then, with the help of a growing number of investigators, knowledge about the biology of;the worm; has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete;wiring diagram; of cell contacts in the animal. Recent years have also brought the first successes in molecularly cloning genes of developmental interest defined only by mutation, using transposon tagging as a generally applicable method for identification of the desired DNA sequences. Reintroduction of cloned DNA sequences into the genome has recently been accomplished. A physical map of the genome has been assembled with a combination of cosmid and YAC genes. This;Book of the Worm; serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists
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2 of 2 people found the following review helpful:
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Reseaching on THE Worm,
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This review is from: The Nematode Caenorhabditis Elegans (The Cold Spring Harbor Monograph Series) (Paperback)
This is an extraordiany book full of information vital for people who are interested or reseaching on C. elegans. It gives detail information as well as illustrations to help guide neophyte undergraduates/graduates to understand why this worm is used as a model for neuroscience reseach. This book covers the genetics, genome, anatomy, cell lineage, development, nerous system, embryology, etc. of C. elegans in as much detail as one will need to know plus useful references. Highly reccommend this book for people working with this worm in the lab.
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Great Resource!,
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This review is from: The Nematode Caenorhabditis Elegans (The Cold Spring Harbor Monograph Series) (Paperback)
A must-have for any C. elegans laboratory or any researcher interested in beginning to work with C. elegans.
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Inside This Book
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First Sentence:
Caenorhabditis elegans is a small, free-living soil nematode found commonly in many parts of the world. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
vulval cell lineages, gut granule birefringence, distal tip cells, early larval lethal, hypodermal ridge, ventral body muscles, defective dauer formation, linker cell, motor neuron classes, rhabditis briggsae, weak kinker, transient bloating, variable bloating, egl genes, nonfunctional nonmotile sperm, pachytene karyotype analysis, roller mutants, severe coiler, weak coiler, late larval lethal, strong dumpy, larva morphogenesis, roller dumpy, eggs arrest, precursor cell fates Key Phrases - Capitalized Phrases (CAPs): (learn more)
The Nematode Caenorhabditis, John White, John Sulston, Jonathan Hodgkin, Laboratory of Molecular Biology Cambridge, Donna Albertson, Rockefeller University Press, Genetics of Cell Lineage, Jim Priess, New York, Bob Horvitz, Cell Biol, Marty Chalfie, National Institutes of Health, Residues Codon New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Caenorhabditis elegans is a small, free-living soil nematode found commonly in many parts of the world. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
vulval cell lineages, gut granule birefringence, distal tip cells, early larval lethal, hypodermal ridge, ventral body muscles, defective dauer formation, linker cell, motor neuron classes, rhabditis briggsae, weak kinker, transient bloating, variable bloating, egl genes, nonfunctional nonmotile sperm, pachytene karyotype analysis, roller mutants, severe coiler, weak coiler, late larval lethal, strong dumpy, larva morphogenesis, roller dumpy, eggs arrest, precursor cell fates Key Phrases - Capitalized Phrases (CAPs): (learn more)
The Nematode Caenorhabditis, John White, John Sulston, Jonathan Hodgkin, Laboratory of Molecular Biology Cambridge, Donna Albertson, Rockefeller University Press, Genetics of Cell Lineage, Jim Priess, New York, Bob Horvitz, Cell Biol, Marty Chalfie, National Institutes of Health, Residues Codon New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 4
books:
2
books
cite this book:
- BIOS Instant Notes in Molecular Biology by Phil Turner on 4 pages
- New York, New York! (Baby-Sitters Club Super Special, No. 6) by Ann M. Martin on page 337
- North Carolina (It's My State!) by Ann Graham Gaines in Back Matter
- New York by Tama Janowitz in Back Matter
- Computational Neuroanatomy: Principles and Methods by Giorgio A. Ascoli on page 81
- Calcium Signaling, Second Edition (Methods in Signal Transduction) by James W. Putney Jr. on page 181
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