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Neurobiology of Addiction
 
 

Neurobiology of Addiction [Hardcover]

George F. Koob (Author), Michel Le Moal (Author)
4.0 out of 5 stars  See all reviews (1 customer review)

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Book Description

0124192394 978-0124192393 November 1, 2005 1
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts - a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective.

The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.

· Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction
· Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work
· Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

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Editorial Reviews

Review

"Competent, comprehensive, and extensively referenced, the book is clearly appropriate for researchers in the field. However, what sets it apart from other books... are the synthetic chapters, which constitute a remarkably cogent introduction to addiction, a detailed general discussion of animal models of addiction, thoughtful descriptions of competing neurobiologic theories of addiction, and a translational chapter in which recent findings on neuroimaging are considered and linked to the more fundamental concepts previously used to examine the neurocircuitry of addiction."
--Peter R. Martin, Vanderbilt University Medical School, NEW ENGLAND JOURNAL OF MEDICINE (October 19, 2006)

"In an impressive and weighty new work, Koob and LeMoal assimilate several thousand references to provide a state-of-the-science proclamation of this progress, while setting our sights for its crucial next phases. ...The Neurobiology of Addiction is a thought provoking tour de force. I expect it to become an instant classic and for future editions to gauge our progress in this exciting and compelling field."
--Trevor Robbins, Department of Experimental Psychology at the Behavioural and Clinical Neuroscience Institute, University of Cambridge in NATURE NEUROSCIENCE (August 2006; Vol 9:8)

"Neurobiology of Addiction is a major achievement and will rapidly become a must-have book on the shelves of addiction researchers... Although it includes much with which readers will disagree and argue, there is also much to relish in Koob and Le Moal's thought-provoking and scholarly text."
--Barry Everitt, U Cambridge in SCIENCE (Vol 314: 6 October 2006)

"With the evidence accumulated in this volume, it is reasonable to discuss addiction as a brain disorder, with significant implications for the directions of research, treatment, and prevention. This text provides us with the state of the art from leading experts at a leading addiction research center. ...It is clearly the very best textbook we could have hoped for..."
--Mark S. Gold and Daniel Logan in PsycCRITIQUES: AMERICAN PSYCHOLOGICAL ASSOCIATION REVIEW OF BOOKS (November 8, 2006)

"Competent, comprehensive, and extensively referenced, the book is clearly appropriate for researchers in the field."
--Peter R. Martin, Vanderbilt University Medical School, NEW ENGLAND JOURNAL OF MEDICINE (October 19, 2006)

"In an impressive and weighty new work, Koob and LeMoal assimilate several thousand references to provide a state-of-the-science proclamation of this progress, while setting our sights for its crucial next phases. ...The Neurobiology of Addiction is a thought provoking tour de force. I expect it to become an instant classic and for future editions to gauge our progress in this exciting and compelling field."
--Trevor Robbins, Department of Experimental Psychology at the Behavioural and Clinical Neuroscience Institute, University of Cambridge in NATURE NEUROSCIENCE (August 2006; Vol 9:8)

"Neurobiology of Addiction is a major achievement and will rapidly become a must-have book on the shelves of addiction researchers... Although it includes much with which readers will disagree and argue, there is also much to relish in Koob and Le Moal's thought-provoking and scholarly text."
--Barry Everitt, U Cambridge in SCIENCE (Vol 314: 6 October 2006)

"This text provides us with the state of the art from leading experts at a leading addiction research center. ...It is clearly the very best textbook we could have hoped for..."
--Mark S. Gold and Daniel Logan in PsycCRITIQUES: AMERICAN PSYCHOLOGICAL ASSOCIATION REVIEW OF BOOKS (November 8, 2006)

"In an impressive and weighty new work, Koob and LeMoal assimilate several thousand references to provide a state-of-the-science proclamation of this progress, while setting our sights for its crucial next phases. ...The Neurobiology of Addiction is a thought provoking tour de force. I expect it to become an instant classic and for future editions to gauge our progress in this exciting and compelling field."
--Trevor Robbins, Department of Experimental Psychology at the Behavioural and Clinical Neuroscience Institute, University of Cambridge in NATURE NEUROSCIENCE (August 2006; Vol 9:8)

"In an impressive and weighty new work, Koob and LeMoal assimilate several thousand references to provide a state-of-the-science proclamation of this progress, while setting our sights for its crucial next phases. ...The Neurobiology of Addiction is a thought provoking tour de force. I expect it to become an instant classic and for future editions to gauge our progress in this exciting and compelling field."
--Trevor Robbins, Department of Experimental Psychology at the Behavioural and Clinical Neuroscience Institute, University of Cambridge in NATURE NEUROSCIENCE (August 2006; Vol 9:8)

Book Description

A thorough review of the extant work on the neurobiology of addiction.

Product Details

  • Hardcover: 504 pages
  • Publisher: Academic Press; 1 edition (November 1, 2005)
  • Language: English
  • ISBN-10: 0124192394
  • ISBN-13: 978-0124192393
  • Product Dimensions: 11.4 x 8.7 x 1.2 inches
  • Shipping Weight: 3.9 pounds (View shipping rates and policies)
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #592,893 in Books (See Top 100 in Books)

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1 of 3 people found the following review helpful:
4.0 out of 5 stars Neuroboilogy of Addiction, April 23, 2008
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This review is from: Neurobiology of Addiction (Hardcover)
this is an excellent review of the current understanding of the brain systems and chemistry involved with addiction. A knowledge of neuroanatomy and neurochemistry as well as genetics is presumed.
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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
acute reinforcing effects, brain reward thresholds, nondependent rats, alcohol deprivation effect, aversive stimulus effects, allostatic view, cocaine reinstatement, brain stress systems, acute positive reinforcing effects, drug reward pathways, protein kinase transducers, acute reinforcing actions, allostasis model, bic dopamine system, nondependent animals, allostatic state, somatic withdrawal signs, purposive symptoms, reticular pontine nucleus, reward set point, escalating cocaine use, brain reward function, nicotine abstinence syndrome, excessive drug intake, incentive salience attribution
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Brain Research, United States, American Journal of Psychiatry, European Journal of Pharmacology, Archives of General Psychiatry, Life Sciences, National Institute, American Psychiatric Association, Neuroscience Letters, Journal of Neurochemistry, Molecular Pharmacology, Nature Neuroscience, Pharmacological Sciences, Journal of Studies, Journal of the American Medical Association, Biological Psychiatry, Raven Press, Plenum Press, Rodriguez de Fonseca, World Health Organization, British Journal of Pharmacology, New England Journal of Medicine, Academic Press, Addictive Behaviors
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