Although a tremendous body of data has been gathered on the neurochemical changes engendered by exposure to drugs of abuse, the cellular mechanisms responsible for the changes remains unclear. In The Neurochemistry of Drugs of Abuse Syed F. Ali and his co-authors examine the cellular and molecular mechanisms of drugs of abuse (such as cocaine and substituted amphetamines) as well as drugs that have been proposed for the treatment of drug addiction (such as ibogaine, phenyltropane, and phentermine-fenfluramine).
Among the contributors, FDA researchers present the clinical aspect in the development of medications designed to treat drug addiction. Other chapters are devoted to the underlying mechanisms of drug addiction, such as gene expression/molecular mechanisms, medication development, free-radical induced neurotoxicity, and specific neuronal markers.
Bringing together both clinical and basic scientists in a multidisciplinary and multinational forum, The Neurochemistry of Drugs of Abuse presents a significant exchange of ideas in this expanding field of research.
