Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most divers and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological, and therapeutic aspects of chosen research areas.
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"...contain[s] some well written chapters which are not only informative, up to date but also thought stimulating and will be a regular source of reference for anyone owning this book."
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From the Back Cover
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.
Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by a relatively selective degeneration of dopaminergic neurons, a loss of striatal dopamine, and intracellular inclusions. Current treatment consists of a dopamine replacement strategy, primarily using the dopamine precursor levodopa. However the majority of patients experience intolerable drug-related side effects, an unacceptable level of disability, and an increased mortality rate. Accordingly, there has been intense interest in the development of a 'neuroprotective therapy' that can prevent neuronal degeneration and slow or stop disease progression.
It is likely that a cascade of events involving free radicals and oxidative stress, mitochondrial dysfunction with a bioenergetic impairment, excitotoxicity, and a rise in intracytoplasmic free calcium with activation of biodestructive enzymes contributes to the neurodegenerative process.
There is also interest in the role of apoptotic cell death in neurodegeneration and the possibility that some small molecules can provide neuroprotection or neuronal rescue by upregulating cellular defenses through the induction of translational changes and new protein synthesis.
This is the first book to comprehensively review the factors implicated in the pathogenesis of cell death in PD. Each chapter of this book examines a different factor and considers the evidence supporting its participation in the neurodegenerative process and specific strategies based on this mechanism that might lead to neuroprotection.
Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by a relatively selective degeneration of dopaminergic neurons, a loss of striatal dopamine, and intracellular inclusions. Current treatment consists of a dopamine replacement strategy, primarily using the dopamine precursor levodopa. However the majority of patients experience intolerable drug-related side effects, an unacceptable level of disability, and an increased mortality rate. Accordingly, there has been intense interest in the development of a 'neuroprotective therapy' that can prevent neuronal degeneration and slow or stop disease progression.
It is likely that a cascade of events involving free radicals and oxidative stress, mitochondrial dysfunction with a bioenergetic impairment, excitotoxicity, and a rise in intracytoplasmic free calcium with activation of biodestructive enzymes contributes to the neurodegenerative process.
There is also interest in the role of apoptotic cell death in neurodegeneration and the possibility that some small molecules can provide neuroprotection or neuronal rescue by upregulating cellular defenses through the induction of translational changes and new protein synthesis.
This is the first book to comprehensively review the factors implicated in the pathogenesis of cell death in PD. Each chapter of this book examines a different factor and considers the evidence supporting its participation in the neurodegenerative process and specific strategies based on this mechanism that might lead to neuroprotection.
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Inside This Book
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Key Phrases - Statistically Improbable Phrases (SIPs):
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fetal dopamine neurones, oxidative radical levels, paraneural tissues, motor neurone death, trophic withdrawal, nigral neurones, striatal dopamine turnover, neuromelanin granules, old gerbils, nigral cell death, neuronal energy metabolism, dopaminergic neurones, excitotoxic hypothesis, brain iron, oxidized protein, focal ischaemia, striatal neurones, cholinergic neurones, haem proteins, hippocampal neurones, focal cerebral ischaemia Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Natl Acad, New York, Free Radical Res, Academic Press Limited, Neural Transm, Parkinson's Disease Copyright, Table of Contents, Parkinson Study Group, Life Sci, Trends Neurosci, Blood Flow Metab, Acta Neuropathol, Raven Press, Movement Disorders, Cell Biol, Trends Pharmacol, Cancer Res, Spencer Smith, Neural Transco, Jimenez Jimenez, Acta Neurol, Treatment of Parkinson Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
fetal dopamine neurones, oxidative radical levels, paraneural tissues, motor neurone death, trophic withdrawal, nigral neurones, striatal dopamine turnover, neuromelanin granules, old gerbils, nigral cell death, neuronal energy metabolism, dopaminergic neurones, excitotoxic hypothesis, brain iron, oxidized protein, focal ischaemia, striatal neurones, cholinergic neurones, haem proteins, hippocampal neurones, focal cerebral ischaemia Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Natl Acad, New York, Free Radical Res, Academic Press Limited, Neural Transm, Parkinson's Disease Copyright, Table of Contents, Parkinson Study Group, Life Sci, Trends Neurosci, Blood Flow Metab, Acta Neuropathol, Raven Press, Movement Disorders, Cell Biol, Trends Pharmacol, Cancer Res, Spencer Smith, Neural Transco, Jimenez Jimenez, Acta Neurol, Treatment of Parkinson Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
Citations (learn more)
3
books
cite this book:
- Age Right: Turn Back the Clock with a Proven, Personalized, Anti-Aging Program by Karlis Ullis in Back Matter
- Parkinson's Disease: Diagnosis and Clinical Management by William J. Weiner on page 353
- Biomedical Chemistry: Applying Chemical Principles to the Understanding and Treatment of Disease by Paul F. Torrence on page 341
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