This edition synthesizes state-of-the-art knowledge from a variety of disciplines, including clinical medicine, pathology, genetics, physiology, biochemistry and related fields. The primary focus is on clinical evaluation and management in the newborn; there is also coverage detailing the most sophisticated technology available for studying disturbances in the structure and function of the infantile nervous system. Insights are offered into neonatal seizures, including material on seizure identification through simultaneous video-EEG monitoring; deleterious effects of seizures in both the experimental animal and human newborn; and advances in pharmacokinetics. The book also discusses disease-related issues such as the neuropathology, pathogenesis, determination, and clinical aspects of hypoxic-ischemic encephalopathy; intracranial haemorrhage and extra-corporeal membrane oxygenation; intraventricular haemorrhage in the pre-term infant; bilirubin brain injury, including new understandings for the determinants of bilirubin neurotoxicity; and much more.




