Neuronal Mechanisms of Memory Formation: Concepts of Long-term Potentiation and Beyond [Hardcover]

Christian Hölscher (Editor)

Book Description

ISBN-10: 052177067X | ISBN-13: 978-0521770675 | Publication Date: November 6, 2000 | Edition: 1

Long-term potentiation (LTP) is the most dominant model for neuronal changes that might encode memory. LTP is an elegant concept that meets many criteria set up by theoreticians long before the model's discovery, and also fits the anatomical data of learning-dependent synapse changes. Since the discovery of LTP, the question has remained regarding how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate synaptic changes observed after learning with changes produced by artificial stimulation of neurons. Some of these studies have failed to find a correlation between the two forms of synaptic plasticity, signalling a need to discuss the concept of LTP and possible alternate processes that could fit the available data. This book presents a selection of ideas that range from supporters of the LTP theory to different novel concepts that have yet to be investigated. This volume will prepare the ground for research in this area in the new millennium.

Editorial Reviews

Review

"...this volume can be recommended for those who wish to succinctly survey the current state of science... This book offers a timely collection of well-written articles..." Timothy J. Teyler, Quarterly Review of Biology

Book Description

Long-term potentiation (LTP) is by far the most dominant model for neuronal changes that might encode memory. Since the discovery of LTP, researchers have questioned how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate these two forms of synaptic plasticity, but have failed to do so.In this book, an international group of neurobiologists and psychologists discuss their latest ideas and data. The results of experiments using electrophysiological techniques in vitro are compared with the results of in vivo experiments. Learning experiments and alternative theoretica l models are also discussed, offering a wide approach.

Product Details

• Hardcover: 528 pages
• Publisher: Cambridge University Press; 1 edition (November 6, 2000)
• Language: English
• ISBN-10: 052177067X
• ISBN-13: 978-0521770675
• Product Dimensions: 10.3 x 7.1 x 1.3 inches
• Shipping Weight: 2.2 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #4,485,516 in Books (See Top 100 in Books)