This monograph describes and quantifies the risk of developing new malignancies among more than 2 million cancer survivors for the period 1973 to 2000, utilizing data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program cancer registries. With chapters organized according to the initial site of cancer, the monograph provides data on the risks of subsequent malignancies for more than 50 adult and 18 childhood cancers, including new data on uncommon sites and individual histologic types. NCI researchers systematically examined the risks of subsequent cancers by gender, age at diagnosis of the initial cancer, and time since diagnosis, as well as the initial treatment and histologic type of certain cancers. Each chapter compares the patterns of multiple cancers with the findings from other studies, and discusses the results in terms of potential risk factors and mechanisms
