Nioxin System 5 for Medium/Coarse, Natural, Normal to Thin-Looking Hair. This 3-Part System contains the following ingredients to help regrow hair. SmoothPlexTM provides moisture, natural shine and smooth control to hair. Activ-RenewalTM delivers bionutrients for a more youthful-looking scalp and fuller, healthier-looking hair. Transactive Delivery SystemTM delivers essential nutrients onto the scalp which improves the appearance of thinning hair and creates an environment for fuller, healthier-looking hair.