Nucleic Acid Structure and Recognition [Paperback]

Stephen Neidle (Author)

Book Description

Publication Date: July 25, 2002

This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigation for nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies are analysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent and non-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.

Editorial Reviews

Review

"Stephen Neidle's excellent new introductory textbook will prove to be very timely, and provides a calm, balanced and objective study of the major advances. ... nothing can replace the perspective that someone of Steve's experience brings to this subject. ... let me congratulate Steve on making this subject so accessible to such a potentially wide audience."--Crystallography News

About the Author

Stephen Neidle, The Institute of Cancer Research (University of London).

Product Details

• Paperback: 272 pages
• Publisher: Oxford University Press, USA; 1 edition (July 25, 2002)
• Language: English
• ISBN-10: 019850635X
• ISBN-13: 978-0198506355
• Product Dimensions: 9.6 x 6.6 x 0.7 inches
• Shipping Weight: 14.6 ounces (View shipping rates and policies)
• Amazon Best Sellers Rank: #2,785,751 in Books (See Top 100 in Books)

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