One Renegade Cell: The Quest For The Origins Of Cancer (Science Masters Series) [Hardcover]

Robert A. Weinberg (Author)

Book Description

Series: Science Masters Series | Publication Date: October 8, 1998

Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell, Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured.Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation.This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.

Editorial Reviews

Amazon.com Review

"Cancer wreaks havoc in almost every part of the human body"--Robert Weinberg's opening remark is a chilling reminder of the pervasiveness of an all-too-familiar disease. Cancer touches most families, and if you have ever wondered why, despite so much time, effort, and money, it has proved such a seemingly intractable problem, then read One Renegade Cell, Robert Weinberg's masterful explanation. As director of the Oncology Research Laboratory at the Whitehead Institute and professor of Biology at MIT, Weinberg has been at the forefront of cancer research for well over a decade.

Unlike most diseases, cancerous tumors are not foreign invaders but "take on the appearance of alien life forms, invaders that enter the body through stealth and begin their programs of destruction from within." But as Weinberg shows, these are deceptive appearances. And since he is foremost a scientist, he finds the truth "subtle and endlessly interesting" and manages to convey fascination for something that most of us dread--cancer. Much of the present increase in cancer is due to increased longevity because "given enough time, cancer will strike every human body."

By telling the story of the historical discovery of cancer, Weinberg is able to introduce gradually the intricacies and complications of the genes and proteins involved (oncogenes, tumor suppressor genes, etc.) for the general reader. He characterizes cancer cells as renegade because, unlike normal body cells, they "disregard the needs of the community of cells," they are "selfish and unsociable," and are only interested in "their own proliferative advantage." By comparison, normal cells hold down cell numbers by "inducing them to commit suicide" (apoptosis).

The understanding of cancer has been developed enormously over the last few decades by Weinberg and the worldwide community of researchers. As Weinberg eloquently shows, cancer research and its related disciplines "have moved from substantial ignorance to deep insight." --Douglas Palmer, Amazon.co.uk

From Publishers Weekly

The last 20 years have brought a revolution in cancer research that will profoundly change diagnosis and treatment of the disease, writes Weinberg in this comprehensive but rigorous introduction to the subject. Weinberg, founder of the Whitehead Institute for Cancer Research and a biology professor at MIT, traces the development of previous theories of cancer, and explains that scientists are now certain that cancer is caused when genes are damaged through a succession of mutations. These can result from damage to a cell's DNA inflicted by mutagens (which can be of foreign origin, such as tobacco smoke, or of internal origin); from normal mistakes made when DNA is copied during cell growth; or from defects in the body's DNA repair machinery. Weinberg discusses the roles of chemical carcinogens, retroviruses and heredity in developing cancer, and explains the body's intricate defenses against tumor growth. Though he argues that cancer will never be fully eradicated because so many mutations occur during long lifetimes ("Given enough time, cancer will strike every human body"), Weinberg is optimistic that increasingly sophisticated understanding of cellular functions will yield more effective treatments for those cancers that cannot be prevented. Though some readers might find the technical sections of the book difficult, it readily conveys the challenge and excitement of scientific discovery. Two illustrations.
Copyright 1998 Reed Business Information, Inc.

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Product Details

• Hardcover: 176 pages
• Publisher: Basic Books; 1st edition (October 8, 1998)
• Language: English
• ISBN-10: 0465072755
• ISBN-13: 978-0465072750
• Product Dimensions: 9.2 x 5.3 x 0.9 inches
• Shipping Weight: 14.4 ounces
• Average Customer Review: 4.9 out of 5 stars  See all reviews (17 customer reviews)
• Amazon Best Sellers Rank: #369,690 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews

22 of 22 people found the following review helpful:

5.0 out of 5 stars Must have: great intro and overview of current research, October 16, 2002

By 

Canay (Hillsboro, OR) - See all my reviews

This review is from: One Renegade Cell: How Cancer Begins (Science Masters Series) (Paperback)

No prior knowledge of cell biology or genetics is required. I have gained an appreciation for the complexity of cancer research thanks to the book. I highly recommend it. You also learn a fair amount of the history of the development of cancer research. And don't think you need to read through hundreds of introductory pages to accomplish this. The book is under 200 pages.

Once again: What I found great about the book is it explains very clearly the current thories on how cancer starts and spreads without requiring any prior knowledge in the field.

For the scientifically oriented who are interested in the details, it has a big reference and endnote section. 5 stars for sure.

15 of 15 people found the following review helpful:

5.0 out of 5 stars Excellent overview for the nonscientist and scientist, November 16, 1999

By 

John Fetter, Ph. D. in Biochemistry (Saint Louis, MO) - See all my reviews

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This review is from: One Renegade Cell: How Cancer Begins (Science Masters Series) (Paperback)

As a scientist, I am familiar with most of the discoveries in cancer research discussed in the book. Weinberg nicely ties them together and explains how one exciting discovery in cancer research led to another. This is an excellent overview of what has been discovered about cancer and what is not known. Weinberg points out that many of the discoveries were from areas of research not directly related to cancer. This book should help the nonscientist understand the complexities of research and why so much time and resources have been required to uncover the mechanisms of cancer. I also highly recommend this book to students at all levels that are interested in any type of research.

8 of 8 people found the following review helpful:

5.0 out of 5 stars Excelent entry to cancer biology, April 10, 2004

By 

David Fourer (Chicago, IL United States) - See all my reviews
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This review is from: One Renegade Cell: How Cancer Begins (Science Masters Series) (Paperback)

There are very few books out that give the reader an overview modern cancer biology. This short book gives a clear picture of a complex and current subject. It uses historical perspective on scientific discovery to enliven the reading. It's well organized and readable without background in biology, but with enough depth to interest biologists in other fields. I also reccomend Robert Weinberg's "Genes and the Biology of Cancer", written with Harold Varmus, which covers the same material in a little more depth.