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The Organic Chemistry of Drug Design and Drug Action, Second Edition [Hardcover]

Richard B. Silverman Ph.D Organic Chemistry
4.6 out of 5 stars  See all reviews (11 customer reviews)

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Book Description

January 26, 2004 0126437327 978-0126437324 2
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.

* New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations
* Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years
* Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Frequently Bought Together

The Organic Chemistry of Drug Design and Drug Action, Second Edition + Foye's Principles of Medicinal Chemistry
Price for both: $164.21

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  • Foye's Principles of Medicinal Chemistry $88.50

Editorial Reviews


"...this text is directed towards graduates who are embarking on a career in medicinal chemistry in the discovery laboratory. Sliverman continues to blur the edges between chemistry and pharmacology in a manner that is incontrovertibly relevant to the discipline of drug design and development."
-Michael E. Cooper, GE Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004

"What stands out in comparison with other books discussed here is that the subjects are generally addressed in detail, and each theoretical point is illustrated with examples of specific drugs. A great deal of knowledge is reflected...that is suitable for both advanced students and PhDs a like who have not yet become acquainted with the area, but who wish to prepare themselves for a career in drug research."

Praise for the First Edition:

"This book is a tour de force in the title area...This book would be appropriate for advanced undergraduate students and graduate students...strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."

"... unified, well-organized and clearly presented ...It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION

"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way..."

"I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen..."
--John G. Topliss, PARKE-DAVIS

"...The organization of this book and the clarity of presentation are outstanding... It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."

Praise for the new edition:

"...intent of the first edition was to provide a textbook for advanced undergraduate students or graduate students, the scope of the second edition has been expanded so that it not only serves the original purpose but also serves as an excellent reference book for practicing medicinal chemists."

--John W. Ellingboe, Wyeth Research for the Journal of Medicinal Chemistry, 2004

"...this book is a thorough overview of drug discovery and development... It is not only an excellent textbook for students but also a valuable resource for those already practicing medicinal chemistry."

John W. Ellingboe, Wyeth Research for the Journal of Medicinal Chemistry, 2004

Book Description

The long-awaited revision of this classic bestseller!

Product Details

  • Hardcover: 617 pages
  • Publisher: Academic Press; 2 edition (January 26, 2004)
  • Language: English
  • ISBN-10: 0126437327
  • ISBN-13: 978-0126437324
  • Product Dimensions: 1.6 x 7.5 x 10.2 inches
  • Shipping Weight: 3.4 pounds (View shipping rates and policies)
  • Average Customer Review: 4.6 out of 5 stars  See all reviews (11 customer reviews)
  • Amazon Best Sellers Rank: #336,967 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews
16 of 16 people found the following review helpful
5.0 out of 5 stars Outstanding... May 5, 2005
This is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry professor at Northwestern University, and in this book he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level it's all chemistry, and mostly organic chemistry. Thus, understand the chemistry and you will go a long way in understanding drug action. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his or her traditional education.

The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, patents and clinical trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed manner. The chapter on enzyme inhibition is long and detailed and it's breathtaking. This is a key chapter because many major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anticancer, antiviral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which are after all the key to understanding their properties.
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2 of 2 people found the following review helpful
5.0 out of 5 stars Fantastic Book for chemists and medicinal chemists February 8, 2009
Some books of this nature tend to focus on the synthesis of drug molecules and less about how they work and why. This book is just the opposite and walks the reader through a logical progression of drug discovery, design and target specificity. This book makes a great introduction to Goodman & Gilman's The Pharmacological Basis of Therapeutics which could be considered the bible of the subject.
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5.0 out of 5 stars Excellent read compared to Foye July 17, 2013
Format:Hardcover|Verified Purchase
We use Foye for Pharmacy students and this text distinguishes itself by being an easier read and having more illustrative examples. That said, it won't replace the drug-class focused chapters in Foye, but this is a much better textbook for fundamentals of medicinal chemistry.
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5.0 out of 5 stars great June 25, 2013
Format:Hardcover|Verified Purchase
it is just what required for my course, and it covers most of my lectures, highly recommended for medical chemistry students
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4.0 out of 5 stars For school March 16, 2013
By Serraz
Format:Hardcover|Verified Purchase
It's for school. Covers a lot of information with regards to drug design and it's fairly thorough. That being said, I don't particularly read my textbooks very often, so if you want it for fun, don't take just my word on it.
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Format:Hardcover|Verified Purchase
For an advanced text the author makes the comprehension of the material manifestly manageable and attainable. The wealth and body of knowlege of organic chemistry must be taken by the reins and commanded out of necessity for its pressentation. It is self-evident that this Herculean effort resulted in a brilliant and clear distillation of theory and applicaiton in the author's text.
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