Organic Chemistry of Drug Design and Drug Action (1) (Hardcover)

by Richard B. Silverman (Author) "Medicinal chemistry is the science that deals with the discovery or design of new therapeutic chemicals and their development into useful medicines..." (more)
Key Phrases: New York, Academic Press, General References (more...)

Editorial Reviews

Review
"This book is a tour de force in the title area....This book adopts a novel format that focuses on the rational chemical underpinnings to both drug discovery and drug development. It seeks to illuminate the workings of drugs at the molecular level. Thus, this book contrasts with the traditional presentation which is organized around various classes of drugs....This book would be appropriate for advanced undergraduate students and graduate students and would probably be well suited as a text for course applications, especially at the graduate level. It is strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--Bruce E. Maryanoff, R.W. Jouhnson Pharnaceutical Research Institute, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vo. 115, No.12, 1993

"For the first time the principles of medicinal chemistry/pharmacology are collected in a unified, well-organized and clearly presented fashion. It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--CARL KAISER, Ph.D., Director, Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION

"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way...The book will turn out to be very popular with students because the material is presented clearly...The numerous superb illustrations included are used very effectively by the author to communicate and/or clarify concepts and ideas."
--William C. Groutas, Ph.D., Professor of Chemistry, WICHITA STATE UNIVERSITY

"I find [Chapter 8] to be an unusually comprehensive, clear and well organized discussion on prodrugs. Although the concepts are complex, they are presented in a logical, easily understood format. Dr. Silverman's use of schematics to illustrate both chemical and biochemical principles is especially effective and should be easily comprehended by the intended audience. I found myself reading for interest and enjoyment rather than searching for mistakes. The references are focused and current. It should become a standard text in short order."
--Anthony A. Sinkula, Ph.D., THE UPJOHN COMPANY

"I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen and at about the right level."
--John G. Topliss, Ph.D., PARKE-DAVIS

"This book emphasizes the organic chemical aspects of medicinal chemistry....The organization of this book and the clarity of presentation are outstanding....The book very clearly presents medicinal chemistry as a unified discipline based on sound principles of organic chemistry. It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY -- Review

Review
"This book is a tour de force in the title area....This book adopts a novel format that focuses on the rational chemical underpinnings to both drug discovery and drug development. It seeks to illuminate the workings of drugs at the molecular level. Thus, this book contrasts with the traditional presentation which is organized around various classes of drugs....This book would be appropriate for advanced undergraduate students and graduate students and would probably be well suited as a text for course applications, especially at the graduate level. It is strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--Bruce E. Maryanoff, R.W. Jouhnson Pharnaceutical Research Institute, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vo. 115, No.12, 1993

"For the first time the principles of medicinal chemistry/pharmacology are collected in a unified, well-organized and clearly presented fashion. It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--CARL KAISER, Ph.D., Director, Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION

"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way...The book will turn out to be very popular with students because the material is presented clearly...The numerous superb illustrations included are used very effectively by the author to communicate and/or clarify concepts and ideas."
--William C. Groutas, Ph.D., Professor of Chemistry, WICHITA STATE UNIVERSITY

"I find [Chapter 8] to be an unusually comprehensive, clear and well organized discussion on prodrugs. Although the concepts are complex, they are presented in a logical, easily understood format. Dr. Silverman's use of schematics to illustrate both chemical and biochemical principles is especially effective and should be easily comprehended by the intended audience. I found myself reading for interest and enjoyment rather than searching for mistakes. The references are focused and current. It should become a standard text in short order."
--Anthony A. Sinkula, Ph.D., THE UPJOHN COMPANY

"I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen and at about the right level."
--John G. Topliss, Ph.D., PARKE-DAVIS

"This book emphasizes the organic chemical aspects of medicinal chemistry....The organization of this book and the clarity of presentation are outstanding....The book very clearly presents medicinal chemistry as a unified discipline based on sound principles of organic chemistry. It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY

See all Editorial Reviews

Product Details

• Hardcover: 422 pages
• Publisher: Academic Press; 1st edition (January 15, 1992)
• Language: English
• ISBN-10: 0126437300
• ISBN-13: 978-0126437300
• Product Dimensions: 9.5 x 6.6 x 1 inches
• Shipping Weight: 1.8 pounds
• Average Customer Review: 4.6 out of 5 stars See all reviews (5 customer reviews)
• Amazon.com Sales Rank: #1,024,563 in Books (See Bestsellers in Books)

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Customer Reviews

Most Helpful Customer Reviews

8 of 8 people found the following review helpful:

5.0 out of 5 stars Outstanding..., May 5, 2005

By	Ashutosh Jogalekar "(Joglekar)" (Atlanta, GA) - See all my reviews (REAL NAME)

This review is from: The Organic Chemistry of Drug Design and Drug Action, Second Edition (Hardcover)

This is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry Professor at Northwestern University, and in this book, he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level, it's all chemistry, and mostly organic chemistry. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his traditional education.
The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, and clinical testing and trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed way. The chapter on enzyme inhibition is long and detailed, and it's breathtaking. Which is important because almost all major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anti-cancer, anti-viral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs, and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which after all is what controls their properties. The lucidity of the book is such that a beginning graduate well-versed with the basic principles of general and organic chemistry can easily understand all the contents.
This book is so interesting and illuminating that it's one of the very few academic books which I have actually read from the first to the last page, with every word in between. In fact, it even makes great bedside reading! Truly a must-have book for all chemists and biologists of every kind, interested in how drugs work.

5.0 out of 5 stars Fantastic Book for chemists and medicinal chemists, February 8, 2009

By	Eric Ballard "Scientist" (Charlottesville, VA United States) - See all my reviews (REAL NAME)

This review is from: The Organic Chemistry of Drug Design and Drug Action, Second Edition (Hardcover)

Some books of this nature tend to focus on the synthesis of drug molecules and less about how they work and why. This book is just the opposite and walks the reader through a logical progression of drug discovery, design and target specificity. This book makes a great introduction to Goodman & Gilman's The Pharmacological Basis of Therapeutics which could be considered the bible of the subject.

3 of 5 people found the following review helpful:

5.0 out of 5 stars Check out the new edition of this book, February 3, 2004

By A Customer

There is a new considerably expanded and updated edition available of Silverman's already classic text as of Jan/04. ISBN is 0-12-643732-7. Check it out... price is comparable to the earlier edition.