Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition, Second Edition [Hardcover]

Richard B. Silverman Ph.D Organic Chemistry (Author)

Book Description

ISBN-10: 0126437319 | ISBN-13: 978-0126437317 | Publication Date: March 14, 2002 | Edition: 2

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.

This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Illustrates the organic mechanism associated with each enzyme-catalyzed reaction
Makes the connection between organic reaction mechanisms and enzyme mechanisms
Compiles the latest information about molecular mechanisms of enzyme reactions
Accompanied by clearly drawn structures, schemes, and figures
Includes an extensive bibliography on enzyme mechanisms covering the last 30 years
Explains how enzymes can accelerate the rates of chemical reactions with high specificity
Provides approaches to the design of inhibitors of enzyme-catalyzed reactions
Categorizes the cofactors that are appropriate for catalyzing different classes of reactions
Shows how chemical enzyme models are used for mechanistic studies
Describes catalytic antibody design and mechanism
Includes problem sets and solutions for each chapter
Written in an informal and didactic style

Editorial Reviews

Review

Praise for the First Edition
"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From the Publisher

KEY FEATURES

Shows how enzyme-catalyzed reactions are simply efficient organic reactions Emphasizes the connection between organic reaction mechanisms and enzyme mechanisms Explains how enzymes can accelerate the rates of chemical reactions with high specificity Uses selected enzymes to demonstrate general mechanisms of enzyme-catalyzed reactions Compiles the latest information about molecular mechanisms of enzyme reactions Illustrated with a vast array of clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms Describes approaches to the design of enzyme inhibitors Covers catalytic antibody design and mechanisms Provides problem sets and solutions for each chapter --This text refers to an out of print or unavailable edition of this title.

See all Editorial Reviews

Product Details

• Hardcover: 800 pages
• Publisher: Academic Press; 2 edition (March 14, 2002)
• Language: English
• ISBN-10: 0126437319
• ISBN-13: 978-0126437317
• Product Dimensions: 9 x 5.9 x 1.5 inches
• Shipping Weight: 2.4 pounds (View shipping rates and policies)
• Average Customer Review: 4.5 out of 5 stars  See all reviews (2 customer reviews)
• Amazon Best Sellers Rank: #209,052 in Books (See Top 100 in Books)
  • #4 in Books > Professional & Technical > Professional Science > Chemistry > Organic > Reactions

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Customer Reviews

Most Helpful Customer Reviews

3 of 3 people found the following review helpful:

4.0 out of 5 stars A lot of problems will be solved in later revisions, May 5, 2003

By 

Lemas Mitchell "Libertarian/ Empiricist" (Hunan Changsha) - See all my reviews
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This review is from: Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition, Second Edition (Hardcover)

The index for this book .... For example, there are a fair number of examples of the epoxidation reaction, but not a single pointer toward that in the index of the book. And much the same thing for other types of reactions.

It would also be nice if there was a more clear transfer between basic organic principles and then biological applications.

He does do a good job showing this is some cases (i.e., the benzoin condensation), but a few more parallel examples would have been very useful.

6 of 8 people found the following review helpful:

5.0 out of 5 stars Professor Silverman does it again!, June 16, 2000

By A Customer

This review is from: The Organic Chemistry of Enzyme-Catalyzed Reactions (Hardcover)

This book is an excellent resource for undergraduate and graduate students studying enzyme chemistry and organic mechanisms. Prof. Silverman does a fine job of giving many different examples of enzyme mechanisms. By not focusing totally on one kind of enzyme or catalysis, he succeeds in painting a broad picture for the reader, while not sacrificing content. The only drawback to this edition is the large amount of typographical errors that appear throughout. Perhaps better editing is in order for future editions.