On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest. The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however. A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand. This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!
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5 of 5 people found the following review helpful:
5.0 out of 5 stars
A Necessity for Organic Chemistry Success!,
By Christopher Fung (San Francisco, CA United States) - See all my reviews
This review is from: Organic Chemistry, Study Guide and Solutions Manual (Paperback)
If you are a student of organic chemistry using the textbook, Organic Chemistry, by the same author, I highly recommend purchasing this manual to accompany the text. Unlike many textbook solution guides, where they only include odd or even numbered problems, this manual includes all the answers to all the problems found in the textbook! In addition to chapter solutions, the author also includes solutions to questions in the special topics section found near the end of the text. Aside from the solutions, there are other goodies. As the title suggests, this book is not just a solutions manual, but a study guide too. After each chapter of solutions, the authors include a short quiz to that can be used to see if the student has grasped the essential concepts for the chapter. Also, in the study guide, you will find a summary of all the important syntheses that comes in handy when doing homework. I used this solutions guide as an undergraduate and can't imagine what type of grades I would have received if it weren't for this book! Highly recommended!
4.0 out of 5 stars
Classic is a classic,
This review is from: Organic Chemistry, Study Guide and Solutions Manual (Paperback)
This book have all information that you will need to study and compreend what is organic chemistry and its basics.
Lots of examples, and a CD that can help you to understant the reactions. A classic would I say.
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