I suppose you could, jeopardizing the hone of your knife. The spine of the blade would likely not be sharp enough, so the hone would be needed to emit spark. I would use the striker for striking and the knife for cutting. But that's me.
I got some extra scrutiny at the airport the last time I flew with it on my bag, but once they found the strange cylindrical piece of metal (lit up BRIGHT on the x-ray) they sent me on my way without confiscating it.