First Sentence:
Based on measurements of kinetic parameters and isotope effects, model reaction studies, and theoretical calculations, a surprisingly large number of hypotheses have been put forward to account for the enormous rate accelerations achieved by orotidine monophosphate decarboxylases (ODCases) [1, 2, 3, 4, 5, 6].
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Key Phrases - Statistically Improbable Phrases (SIPs):
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decarboxylation barrier, phosphoribosyl group, state binding affinity, intrinsic binding free energy, protonation mechanism, ground state destabilization, enzymological data, intrinsic binding energy, substrate carboxylate, reactant state, charged network, destabilization mechanism, enzymatic decarboxylation, electrostatic stress, pyrimidine ring, reaction barrier, transition state stabilization, calculated barrier, invariant amino acids, protonation sites, phosphoryl group, proton affinity, total barrier, yeast enzyme, substrate model
Key Phrases - Capitalized Phrases (CAPs):
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Biol Chem, Proc Natl Acad Sci, Bioorg Chem, Phys Chem, New York, Springer-Verlag Berlin Heidelberg, Annu Rev Biochem, Biochem Biophys Res Comm, Chem Phys, Top Curr Chem, Department of Chemistry, University of Toronto
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