I do a lot of road biking and needed to update my 4 year old Camelbak MULE. I like the MULE, its just a little heavy and clunky (guess that's why its named after a heavy and clunky animal). I have used the Viper on a couple of 40 mile rides and can say that I am thoroughly impressed. Here are some major differences between the 2:
WEIGHT: the Viper 4 weighs about a third of the MULE. The materials are cutting edge, durable yet light. The shoulder straps are a mesh combination that stretches to your shape. This pack is so light and comfortable, I forgot I had it on a couple of times.
HYDRATION PACK: Osprey uses an ingenious reservoir that has a molded plastic spine. This makes it easy to remove and distributes the weight evenly through the pack. The result is much more comfortable when compared to Camelbak's "bag of water" that sits as dead weight at the bottom of the pack.
MAGNETIC CLASP: sounds like a small detail, but being able to release/clasp the hose by just snapping it to your chest make a big difference. The last thing I want to do is fuss with a dangling hose on my rides. The mouthpiece also feels better. The bite valve is made of a softer silicon and feels more solid and better made.
HELMET CLASP: part of my trip is on exclusive bike paths, so being able to get the helmet off and out of the way is important. I did this with the MULE by just strapping it around the pack, but this system works more efficiently.
Osprey has a few models of the Viper. This one is the lightest and is designed for a bare bones kind of trip. It has one zippered pocket tastefully lined with a yellow anti-scratch material for sunglasses and such. I was able to easily fit an extra tube (wrapped tightly and taped with tire levers), Co2 mini pump, extra Co2 cartridge, mini tool, patch kit, and a Clif bar. If you use a saddle pouch (which I don't), then this frees up this pocket for you. If you want an extra big pocket for different kinds of trips, or weight is not so much of an issue, get the Viper 7 or 10.
Overall, I was surprised with how much of a difference this light little pack made for my rides. It is perfect for a comfortable 40 or so mile trip in decent weather without refilling. You can always refill it on the trail if you need to, or pair this with a couple of water bottles for those long rides. Osprey also has a lifetime warranty on their stuff, so get this pack, its worth it!