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The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science
 
 
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The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science [Hardcover]

R. Douglas Fields (Author)
4.8 out of 5 stars  See all reviews (24 customer reviews)

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Book Description

December 29, 2009
Despite everything that has been written about the brain, a very important part of this vital organ has been overlooked in most books -- until now. The Other Brain is the story of glia, which make up approximately 85 percent of the cells in the brain. Long neglected as little more than cerebral packing material ("glia" means glue), glia are sparking a revolution in brain science.

Glia are completely different from neurons, the brain cells that we are familiar with. Scientists are discovering that glia have their own communication network, which operates in parallel to the more familiar communication among neurons. Glia provide the insulation for the neurons, and glia even regulate the flow of information between neurons.

But it is the potential breakthroughs for medical science that are the most exciting frontier in glia research today. Diseases such as brain cancer and multiple sclerosis are caused by diseased glia. Glia are now believed to play an important role in such psychiatric illnesses as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson's and Alzheimer's. They are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. Scientists have discovered that glia repair the brain and spinal cord after injury and stroke. The more we learn about these cells that make up the "other" brain, the more important they seem to be.

Written by a neuroscientist who is a leader in the research to reveal the secrets of these brain cells, The Other Brain offers a firsthand account of science in action. It takes us into the laboratories where important discoveries are being made, and it explains how scientists are learning that glial cells come in different types, with different capabilities. It tells the story of glia research from its origins to the most recent discoveries and gives readers a much more complete understanding of how the brain works and where the next breakthroughs in brain science and medicine are likely to come.


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Editorial Reviews

From Booklist

For a hundred years, since Camillo Golgi developed an efficient method of studying brain tissue under the microscope, the specialized brain cells called neurons have been the de facto stars of neuroscience. With the capability for observing live electrical signals between neurons and their associated synapses, it has been assumed that neurons form the cellular wiring that houses the mind. Now, as researcher Fields illustrates in this fascinating overview of contemporary neuroscience, a new and equally vital team of costars in brain functionality is emerging: glial cells, or, simply, glia. Once deemed valuable only as “packing material” or nutritional support for neurons, glia are being recognized for their critical role in everything from childhood learning to mental illness. In 16 absorbing and accessible chapters, Fields gives life to a potentially dry medical topic by eavesdropping on the work of other neuroscientists, past and present, and shows how penetrating glia's secrets offers hope for breakthroughs in healing Alzheimer’s, brain tumors, and even spinal cord injuries. Highly recommended, especially to science lovers and medical professionals. --Carl Hays

Review

The Other Brain offers an insightful, complex, and nuanced picture of the most interesting substance on earth: the matter inside our heads.”

—Anthony Doerr, The Boston Globe


Product Details

  • Hardcover: 384 pages
  • Publisher: Simon & Schuster; 1 edition (December 29, 2009)
  • Language: English
  • ISBN-10: 0743291417
  • ISBN-13: 978-0743291415
  • Product Dimensions: 9.2 x 6.7 x 1.3 inches
  • Shipping Weight: 1.3 pounds (View shipping rates and policies)
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (24 customer reviews)
  • Amazon Best Sellers Rank: #359,113 in Books (See Top 100 in Books)

More About the Author

R. Douglas Fields is the Chief of the Section on Nervous System Development and Plasticity at the National Institute of Child Health and Human Development, a part of the National Institutes of Health (NIH) and Adjunct Professor in the Neuroscience and Cognitive Science Program at the University of Maryland, College Park. In 2004 Dr. Fields founded the scientific journal Neuron Glia Biology, where he is the Editor-in-Chief, and he is a scientific advisor to Scientific American Mind and Odyssey magazines. He is the author of numerous articles in popular magazines including Outside Magazine, The Washington Post Magazine, Scientific American, Scientific American Mind, Odyssey Science Magazine for children and others. He is an internationally recognized authority on neuron-glia interactions, brain development, and the cellular mechanisms of memory. Dr. Fields received advanced degrees at UC Berkeley, San Jose State University, UC San Diego, and he held postdoctoral fellowships at Stanford University, Yale University, and the National Institutes of Health before starting his research laboratory at the NIH in 1994. The author of over 150 articles in scientific journals and books, he also enjoys building guitars, rock-climbing, and scuba diving.

See The Other Brain website at: http://theotherbrainbook.com

 

Customer Reviews

24 Reviews
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Average Customer Review
4.8 out of 5 stars (24 customer reviews)
 
 
 
 
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66 of 68 people found the following review helpful:
5.0 out of 5 stars Destined To Be A Classic, January 21, 2010
By 
James M. Robertson (Baton Rouge, LA USA) - See all my reviews
(REAL NAME)   
This review is from: The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science (Hardcover)
"The Other Brain", written by R. Douglas Fields, Ph.D., is a must read for anyone interested in the scientific basis of higher brain functions. Virtually every educated person knows that brain function is the result of brain cells called neurons. Wrong! Neurons comprise only 10% of brain cells. The majority of other cells in the brain are collectively known as glia. These comprise about 5 distinct groups of brain cells. Research over the past 30 years has shown that these cells are equal partners in cognitive information processing, and may be more important than neurons. In fact, they may actually be directing the networks of neurons that have been considered the basis of intelligence, memory formation and consciousness for over a century.

Additionally, these cells are now considered leading candidates for both the cause and potential treatments of neurological diseases including Alzheimers, Parkinsons, Schizophrenia, Bipolar Disorder, ALS, multiple sclerosis and chronic pain. The use of glia as stem cells in treatment of these conditions, as well as strokes and brain tumors, is currently a hot topic of research. Dr. Fields, Chief of the National Institute of Child Health and Human Development, is preeminently qualified to write about this topic. His life-long research on glia has provided important clues that may eventually lead to treatment or cures for paralysis resulting from spinal cord trauma.

Fields is a consummate storyteller, and has been referred to as "our neural Jacques Cousteau" because of his ability to transform such a difficult subject into an enjoyable and accessible writing style. Most notable is his intermix of vignettes of the life of men who have worked with glia within the body of the text. This includes some of the most exotic and eccentric characters imaginable.

Particularly enjoyable was the brilliant explorer and scientific polyglot Fridtjof Nansen who first proposed in the nineteenth century that glia were involved in higher cognitive functions. He also mapped ocean currents and received the Nobel Peace Prize. Also notable is the driven and hyper-focused pediatrician Carleton Gajdusek who left a comfortable life in research on infantile paralysis to impulsively travel to New Guinea to live with cannibals for several years to study kuru (similar to Mad Cow Disease). He may be the only Nobel Laureate in Medicine to serve time in prison after receiving this prestigious award. Ichiji Tasaki was given laboratory space at the National Institutes of Health until his recent death at the age of 100. He initially built his own equiptment by hand because his research had outpaced the available technology. The significance of his lifelong research continues to influence gliobiologist to this day.

I have read most of the popular text on brain function written by Nobel Laureates, prominent neuroscientists, philosophers, linguist and "science writers". None can match "The Other Brain" as far as thoroughness of scientific facts and ease or reading. It is a real "page turner". It is the only book on brain function that I could not put down until completed. Until you read this remarkable book about glia, "the other half of the brain", your knowledge of brain function is far from complete.
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23 of 24 people found the following review helpful:
5.0 out of 5 stars a journey into an intercellular wonderland, February 15, 2010
This review is from: The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science (Hardcover)
I throughly enjoy reading and studying all of the articles written by the author of this book in Scientific American and other publications. His fascinating articles in Scientific American on glial cells and white matter is was compelled me to read this outstanding book. I was sad when I finished the book, wanting to learn more hoping that there was at least one more chapter left.

After reading and studying this book, I am more easily able to read, understand and appreciate articles about glial cells in heavier publications like Science. This is not a particularly easy read, but accessible to anyone willing to put a lot of thought into the material which brings me to another point. I wish the author would have incorporated more figures and diagrams into the text instead of just splatting a number of photos and diagrams into the center of the book. All of the diagrams are explained very well, but I would have liked to have seen them more closely tied into the text instead of having to turn the pages back and forth. Many of the pictures he has are taken from Science and Scientific American magazine. Figure 26 (the electron microscope picture) for example is also used in Vol. 298 October 2002 of Science. The other diagram used in the same article in Science is curiously missing from this book. If he would have included that cartoon-like diagram shown in the Science article, it would have done a great deal of good in explaining things like gap junctions, calcium waves, glutamate uptake and release and glial communication using ATP and other molecules. That diagram would have been perfect in the part where he started explaining what astrocyes do. Still, this doesn't take anything away from the book. I'm looking forward to whatever articles or books the author writes in the future on this fascinating subject!
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14 of 14 people found the following review helpful:
5.0 out of 5 stars Stunning, February 21, 2010
This review is from: The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science (Hardcover)
From the history of Einstein's stolen brain to the very end I was thrilled. Not only is this exciting storytelling but it is a fast paced narrative about the incredible discoveries made about the human brain just in the last decade...discoveries that change everything. And the people involved are just as excited including Dr. Fields. He not only tells amazing scientific advances in real terms, he helps the novice follow along. I am a 60 year old retired grocery store manager and even I got it...now there is a testimonial! Among the "stunning" I was most amazed to discover that the human brain is completed back to front and is not finished for approx two decades after birth. Can we say teenagers! All other mammals are born with completed brains and not allowed the opportunity to let their environment influence brain development. As Dr. Fields says, "We are allowed to cheat in evolution's battle for food and reproduction. Buy this one!
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