Panic in Level 4: Cannibals, Killer Viruses, and Other Journeys to the Edge of Science [Hardcover]

Richard Preston (Author)

Book Description

Release date: May 27, 2008

Bizarre illnesses and plagues that kill people in the most unspeakable ways. Obsessive and inspired efforts by scientists to solve mysteries and save lives. From The Hot Zone to The Demon in the Freezer and beyond, Richard Preston’s bestselling works have mesmerized readers everywhere by showing them strange worlds of nature they never dreamed of.

Panic in Level 4 is a grand tour through the eerie and unforgettable universe of Richard Preston, filled with incredible characters and mysteries that refuse to leave one’s mind. Here are dramatic true stories from this acclaimed and award-winning author, including:

• The phenomenon of “self-cannibals,” who suffer from a rare genetic condition caused by one wrong letter in their DNA that forces them to compulsively chew their own flesh–and why everyone may have a touch of this disease.
• The search for the unknown host of Ebola virus, an organism hidden somewhere in African rain forests, where the disease finds its way into the human species, causing outbreaks of unparalleled horror.
• The brilliant Russian brothers–“one mathematician divided between two bodies”–who built a supercomputer in their apartment from mail-order parts in an attempt to find hidden order in the number pi (π).

In fascinating, intimate, and exhilarating detail, Richard Preston portrays the frightening forces and constructive discoveries that are currently roiling and reordering our world, once again proving himself a master of the nonfiction narrative and, as noted in The Washington Post, “a science writer with an uncommon gift for turning complex biology into riveting page-turners.”

Editorial Reviews

From Publishers Weekly

The title of New Yorker contributor Preston's new collection refers to the subject of his bestselling The Hot Zone: a series of rooms in a government biohazard laboratory where scientists work with virulent pathogens like the Ebola viruses that would be devastating in the hands of terrorists. The essays (all from the New Yorker) cover such scientific matters as a profile of controversial über-genome mapper Craig Venter; a gene that leads people to cannibalize themselves; and two Russian-Jewish émigré scientists who built a monster computer in their cramped apartment to puzzle out patterns in the value of pi. Preston's essay on the destruction of large swaths of eastern U.S. forests by insect parasites accidentally brought into the country from abroad is the shortest but most compelling. Preston might have done more to update his pieces; for example, the Marburg virus was found in bats last year, supporting his hypothesis that they are the reservoir for Ebola. But Preston's fans will enjoy his showing how few degrees of separation there are between far-flung areas of scientific endeavors. Illus. (June)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From School Library Journal

Adult/High School—Preston gets to the heart of these nonfiction essays by placing himself in the center of the story. The "panic" of the book's title refers to his own when his biohazard suit was breached and he feared he may have been exposed to one of the deadliest known viruses. Two of the pieces involve the brothers Chudnovsky, mathematicians so closely dependent on one another that they refer to themselves as The Mathematician. The author was able to disappear as an interviewer to the extent that he became part of the brothers' portrait. At one point, one Chudnovsky says to the other: "The interviewer answers our questions…. The interviewer becomes a person in the story." Preston used this skill of blending into his accounts to his advantage. Whether he was strapping on gear to climb mammoth hemlocks with arborists trying to understand the diseases killing the great trees of the world or acting as an off-road driver for a couple of men with the disease of self-cannibalization, Preston fit in like a good supporting actor who also happened to be the cameraman, writer, and director. Teens will find these stories compelling. The author has the eyes and language of a fine novelist, but he has the mind of a scientist who is trying to understand some of the most fascinating mysteries of our age.—Will Marston, Berkeley Public Library, CA
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

See all Editorial Reviews

Product Details

• Hardcover: 240 pages
• Publisher: Random House; 1st Printing edition (May 27, 2008)
• Language: English
• ISBN-10: 1400064902
• ISBN-13: 978-1400064908
• Product Dimensions: 6.5 x 1 x 9.5 inches
• Shipping Weight: 1.2 pounds
• Average Customer Review: 3.5 out of 5 stars  See all reviews (33 customer reviews)
• Amazon Best Sellers Rank: #537,469 in Books (See Top 100 in Books)

More About the Author

Richard Preston is the bestselling author of The Hot Zone, The Demon in the Freezer, and the novel The Cobra Event. A writer for The New Yorker since 1985, Preston is the only nondoctor to have received the Centers for Disease Control's Champion of Prevention Award. He also holds an award from the American Institute of Physics. Preston lives outside of New York City.

Most Helpful Customer Reviews

52 of 57 people found the following review helpful

3.0 out of 5 stars RICK "SHAQ" GOLDSTEIN SAYS: "THEY HAD SURVEYED "PI" TO 2,260,321,336 DECIMALS" June 17, 2008

By Rick Shaq Goldstein

Format:Hardcover|Amazon Verified Purchase

The potential reader should be warned that despite the title of the book being "PANIC IN LEVEL 4", only the introduction portion of the book takes place at the Army's Level 4 virus laboratories at Fort Detrick, an Army base in the eastern flank of the Appalachian Mountains in Maryland. This is the headquarters of the United States Army Medical Research Institute of Infectious Diseases. (USAMRIID) "Biosafety Level 4, is the highest and tightest level of biosecurity in a laboratory. Laboratories rated at Biosafety Level 4 are repositories of viruses called hot agents-lethal viruses for which there is no vaccine or effective cure. Level 4 labs are sealed off from the outside world." The author does a tremendous job in this area, as his narration makes you feel as if you're inside a pressurized whole-body-biohazard-suit along with him. You'll feel sweat dripping down every orifice of your body as untreatable "live" vials of Ebola and other deadly diseases are in your presence, and all of a sudden the zipper on your suit opens, or you find a hole in your sleeve or pants. Unfortunately this section ends too quickly and then we are in New York visiting with brothers Gregory and David Chudnovsky, two mathematics geniuses, that have built a supercomputer utilizing mail order parts in their rundown apartment. All in their quest to find hidden order in the number "PI". (The division of the circle's diameter into its circumference.) These brothers have built the equivalent of a Cray Y-MP Supercomputer (At the time, one of, if not "THE" fastest computer in the world.) which cost more than THIRTY-MILLION-DOLLARS... while their home-built computer cost them about SEVENTY-THOUSAND-DOLLARS.... When the author is first greeted at their apartment door by David, as he slowly opened the door he said: "Don't worry, nothing unpleasant will happen to you here. We will not turn you into digits." The temperature in the apartment is unbearable due to the heat this massive computer puts out, and the landlord doesn't know they've created a supercomputer in their apartment. Eventually they break the world record by calculating "PI" to the 2,260,321,336, decimal, which though impressive still doesn't solve the problem. Note: The author calculated and had verified by a "New Yorker Magazine" fact checker, that there was at least ONE-TON-OF-PAPER in Gregory's bedroom.

From there we go to a story about the death of trees in the forest. I believe all six chapters are from prior New Yorker articles. Because of this, some chapters overlap as far as having the same characters or DNA research subjects, so the reader is stuck hearing the exact same information about certain people and subjects. The minute miniscule discussions regarding DNA, genome, bacteria, sequencing equipment, etc. over and over and over... I must admit it was over the head of a layman like me. And it wasn't the type of book I thought I was getting.

There is a really interesting and harrowing chapter on the Ebola virus that educates the reader that there is not only no cure, but it has been almost impossible to find out where and what it comes from. The author points out that just in the canopies of the forests there are a million living entities that haven't even been discovered by modern man. There's a chapter on a unicorn tapestry made in 1500 and as I mentioned earlier in discussing overlapping characters... the "math-brothers" are out of their apartment and reintroduced to the reader as if we've never heard of them before.

The last chapter is entitled "THE SELF-CANNIBALS" which is about Lesch-Nyhan syndrome. I had never heard of it before, and it is a sad, sad, gut-wrenching illness. It will be hard for any human being with even the smallest amount of empathy to not be distressed reading this. One of the tamer passages is: "Over time, his fingers had gotten into his mouth and nose, and had broken out and removed the bones of his upper palate and parts of his sinuses, leaving a cavern in his face. He had also bitten off several fingers. J.J. seemed happy most of the time, except when he was injuring himself." After getting to know the disease and the affect on the poor human beings and their families that are stricken with it, I wish the author would have used a different title for this chapter. One of the phrases used in this chapter was "self-mutilation", which is still awful but I feel it would show a little more dignity.

This book obviously is written with a very high intellect level, but it is not for everyone, and I hope my review will help people to buy and not to buy as the individual case may be. I wish I could have read a review like this before I decided. I wasn't prepared for what I read. Read more ›

29 of 33 people found the following review helpful

3.0 out of 5 stars Felt like bait-and-switch given the title of the book... June 21, 2008

By Thomas Duff HALL OF FAMETOP 500 REVIEWERVINE™ VOICE

Format:Hardcover

This sounded like a great idea when I found it on the shelf at the library... Panic in Level 4: Cannibals, Killer Viruses, and Other Journeys to the Edge of Science by Richard Preston. I opened the book, expecting to have around 200 pages of talk about killer viruses and the war against them. Instead, I got a seemly random assortment of stories that mostly bore little resemblance to the "Panic in Level 4" title. I almost felt like a victim of bait-and-switch.

Contents:
Introduction - Adventures in Nonfiction Writing; The Mountains of Pi; A Death in the Forest; The Search for Ebola; The Human Kabbalah; The Lost Unicorn; The Self-Cannibals; Glossary; Acknowledgments

The title actually comes from the Introduction chapter. It's there that the author relates his story of being allowed to enter a level 4 biohazard room as part of his background research as a writer. This is something that normally is never allowed, but a few rules were bent and he learned what it's like to be working with viruses that can kill you 100% of the time. Had the whole book stayed in that vein, it would have been great. But then Preston launched into an assortment of stories that, in my opinion, failed to deliver on the promise of the intro and title.

The Mountains of Pi examines two mathematicians who built their own supercomputer and dig deeply into the calculations of the value of Pi. Not a bad story in itself, but not exactly "panic" and "level 4" excitement. A Death in the Forest gets into how an insect infestation kills off eastern hemlock trees, and follows the people who try to prevent the deaths. Far from riveting... The Search for Ebola gets back to the title premise a bit, and shows how difficult it is to trace down the source of a disease that has no cure.... The Human Kabbalah then reverts back to the "switch" category by following the story of the mapping of the human genome. An inordinate amount of time is spent looking at the personalities involved between the two groups trying to complete the mapping, as well as the motivation and lifestyle of each. Again, perhaps not a bad story in itself, but off the path of expectations. The Lost Unicorn goes into the efforts to restore the Unicorn Tapestries and the computing power needed to blend together digital images of the tapestries so that a digital record of the work is maintained. We're not only "off the path" now, but I'm not sure there was ever a path to begin with! The Self-Cannibals veers back towards the title, covering a syndrome known as Lesch-Nyhan where people are compelled to mutilate themselves in strange and painful ways. It could be a book by itself, but unfortunately it's a small chapter that only helps to counterbalance the other chapters that were out in left field.

I really enjoyed Preston's other works, which capture the danger and intensity of working with killer illnesses that approach a 100% level of mortality. Panic lacked a cohesive thread based on the title, and I was really disappointed that so many of the chapters failed to deliver on expectations. If you come into the book knowing that it's not all about microbes and germs, you may be more forgiving on the choice of chapter subjects. Unfortunately, I didn't, and I wasn't... Read more ›

9 of 10 people found the following review helpful

5.0 out of 5 stars Misleading title, yes. Good book, yes. September 2, 2009

By D. Swallow

Format:Paperback

I don't understand why people are getting so up in arms about the title. It's an attention grabber, which is what titles are supposed to do. The book is a collection of short pieces about non-fiction subjects. To those who are complaining that the book isn't as exciting as Preston's other work, please take note: this is not fiction, and is therefore doesn't have as much of an excitement factor. If you take the book for what it is, I strongly believe that you will be pleased. Each piece within the book was fascinating (except maybe the bit about the Unicorn Tapestries, but that's just personal bias). I found this book to be easy to read, highly informative, and very enjoyable overall. I especially enjoyed reading about the Chudnovskys and the rivals in the Human Genome Project. Happy reading to all!

6 of 7 people found the following review helpful

1.0 out of 5 stars extremely disappointing June 18, 2008

By Brenda Pink

Format:Hardcover|Amazon Verified Purchase

Do not buy this book because of the title. The book has nothing to do with Level 4 containment. And that was the disappointment. The book consists of several short stories that were originally published in a newspaper. A vast majority of the book deals with two mathematician brothers who really lead a very boring life trying to determine pi to umpteen decimals. And Preston goes on and on about their life. The Ebola chapter is an interesting chapter, but still has nothing to do with Level 4. The chapter on a strange disease where people are eating themselves is very interesting...again, nothing to do with Level 4. Another chapter describes the steps taken to photograph a tapestry called "The Unicorn". Nothing exciting there either. The introduction to the book goes on seemingly forever, giving all the punch lines to the chapters and is the only reference to Panic in Level 4 when the author is potentially exposed to microbes while researching part of the book. That's it. "Panic in Level 4" refers to the introduction in the book. The book is also poorly written in that even each chapter seems disjointed. The people eating disease chapter is possibly the best written in the book.

This does not compare in the slightest to Hot Zone, which is a far more cohesively written book and interesting book, in my opinion.