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Pediatric Psychopharmacology: Principles and Practice [Hardcover]

Andres Martin (Author), Lawrence Scahill (Author), Dennis S. Charney (Author), James F. Leckman (Author)
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October 17, 2002 0195141733 978-0195141733 1
Pediatric Psychopharmacology: Principles and Practice is an authoritative and comprehensive text on the use of medication in the treatment of children and adolescents with serious neuropsychiatric disorders. This benchmark volume consists of 56 chapters written by internationally recognized leaders, and is divided into four interrelated sections. The first, Biological Bases of Pediatric Psychopharmacology, reviews key principles of neurobiology and the major psychiatric illnesses of childhood from a perspective rooted in developmental psychopathology. The second, Somatic Interventions, presents the major classes of psychiatric drugs, as well as complementary and alternative somatic interventions, such as electroconvulsive therapy (ECT), transcranial magnetic stimulation (rTMS), and naturopathic approaches. The third and longest section, Assessment and Treatment,starts with clinical assessment, diagnostic evaluation, and comprehensive treatment planning, and goes on to cover the evidence-based analysis of drug treatments for the major disorders. Special populations (such as children with comorbid mental retardation, substance abuse or medical illness) are specifically discussed, and the coordination of their treatment with non-somatic therapies is explicitly addressed. The final section, Epidemiologic, Research, and Methodological Considerations, deals with broad population-relevant topics such as regulation and policy, pharmacoepidemiology, and the critical importance of sound ethical principles for clinical investigation. The book concludes with an appendix on generic and commercial drug name equivalencies, preparations, and available dosages.
This timely text is intended for child and adolescent psychiatrists, general and developmental pediatricians, family practitioners, general psychiatrists, and other mental health professionals who work with children and adolescents.

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Editorial Reviews

From The New England Journal of Medicine

It was six men of Indostan To learning much inclined, Who went to see the Elephant (Though all of them were blind), That each by observation Might satisfy his mind. John Godfrey Saxe (1816-1887) Pediatric psychopharmacology has been a much maligned and often misunderstood form of treatment for children with clinically significant psychiatric and behavioral disturbances. This legacy is largely attributable to the same ignorance that plagued the blind men. Critics and faux scientists have all grabbed a portion of the problem for their own purposes or polemics, rather than appreciating the large and complex nature of the problems involved in the diagnosis and treatment of children and adolescents with psychiatric illness. This is a particularly sad state of affairs, since the estimated prevalence of such disorders is approximately 20 percent. It would appear that less than 50 percent of affected children are ever evaluated; still fewer receive any semblance of treatment. This lack of attention is particularly unfortunate because there are many safe and effective treatments (both somatic and psychosocial) for this group of patients. In the Saxe poem based on the Indian fable, we learn of a nearly futile search by the curious yet unseeing. In some ways, this has been the history of the study of pediatric psychopharmacology. However, much has changed in the past two decades, as we have begun to move out of the darkness toward a systematic approach to this vitally important area of investigation and treatment. Led by the spirit and wisdom of their mentor and colleague, Donald J. Cohen (1940-2001), the editors have assembled an extraordinary international team of more than 100 investigators and clinicians to grapple with the complexities of pediatric psychopharmacology. Like the fabled blind men, the authors have approached complex issues from many perspectives, but rather than stumble around haphazardly and arrive at snap conclusions, the editors have carefully organized the scientific knowledge into four distinct sections. Most important, each chapter of this well-edited book maintains the essential developmental perspective on symptoms and treatments relevant to children and adolescents. The first section, "Biological Bases of Pediatric Psychopharmacology," includes detailed discussions of developmental neurophysiology, pharmacokinetics, psychopathology, and genetics, followed by a discussion of the neurobiology of specific disorders. "Somatic Interventions" focuses on the first of two distinctly different approaches to neuropharmacology, carefully reviewing the function and use of psychopharmacologic agents according to class. One legitimate criticism of the use of psychotropic medications in young people is that many practitioners, when faced with behavioral problems, simply "give the medicine a try." To counter this trend, "Assessment and Treatment" provides a resource for the evaluation of children with specific symptoms and disorders, including a guide to diagnostic instruments and rating scales for monitoring the well-described treatments. The authors recognize that the general rules of practice may not apply neatly to special populations, such as patients with mental retardation or preschoolers. "Epidemiological, Research, and Methodological Considerations," the fourth section, covers the context in which the treatments are developed and used, including the research methods, the relevant ethical considerations, the evidence-based approach to the use of medications with psychotherapy, and regulatory issues. If there is so much knowledge regarding this topic, why has a comprehensive book of this quality been so long in coming? Perhaps it is because, as Klin and Cohen have suggested, any indication for the use of drugs in childhood "is often considered an `orphan' indication, as if childhood was an anomalous and rare state of being and the diseases of childhood were of secondary importance" ("Theoretical Perspectives on Autism." Signal [World Association of Mental Health] 1994;2(2):7-12.). I hope that Pediatric Psychopharmacology and the work that it represents will allow for the thoughtful, scientific adoption of pediatric psychopharmacology, rather than leave it in the nether lands of clinical science. It may even lead to an end to some of the controversies, ambivalence, pseudoscience, and false beliefs about treating children and adolescents who have serious psychiatric illnesses. Pediatricians, psychiatrists, family practitioners, neurologists, and other practitioners who use this book for primary learning as well as for reference may be able to avoid the fate of the blind men: So oft in theologic wars, The disputants, I ween Rail on in utter ignorance Of what each other mean And prate about an Elephant Not one of them has seen! Bennett L. Leventhal, M.D.
Copyright © 2003 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

Review


"A comprehensive and well-written book on psychopharmacology in children and adolescents that has the potential to be of use to all levels of training and experience. . . Like its older sibling, the Comprehensive Textbook of Child and Adolescent Psychiatry, this book is off to a good start. And with its family history, it has no choice but to be a huge and long-lasting success." --Journal of Child and Adolescent Psychopharmacology


"...the first comprehensive volume in child and adolescent psychiatry that brings together, in one exhaustive and well-referenced tome, an integration of the current knowledge in the burgeoning field of pediatric psychopharmacology and neurobiology as it impacts the treatment of children and adolescents with psychiatric disorders...Pediatric Psychopharmacology may well find its place on the bookshelves, alongside other reference volumes, of all who treat children and adolescents with psychiatric disorders...an invaluable resource that summarizes in concise detail the state-of-the-art knowledge base of neurobiology and psychopharmacology for pediatric patients while integrating it into a framework that considers the total patient in a much broader treatment context."--Journal of Clinical Psychiatry


"...each chapter of this well-edited book maintains the essential developmental perspective on symptoms and treatments relevant to children and adolescents. I hope that Pediatric Psychopharmacology and the work that it represents will allow for the thoughtful, scientific adoption of pediatric psychopharmacology, rather than leave it in the nether lands of clinical science. It may even lead to an end to some of the contoversies, ambivalence, pseudoscience, and false beliefs about treating children and adolescents who have serious psychiatric illnesses."--New Englang Journal of Medicine, September 18, 2003


". . . an enormous editorial feat . . . well arranged, well organized, and easy to read . . will be appreciated by many in the field. It would be a very useful and well-appreciated reference volume for anybody treating children and adolescents." --The American Journal of Psychiatry


". . . comprehensive, organized, well written, and a pioneer in the field of child mental health care . . . an essential reference book . . . an important and blessed beginning for the developing field of pediatric psychopharmacology." --Israel Journal of Psychiatry and Related Sciences


"...should be highly useful to pediatricians as well as child psychiatrists...well written and accessible to the reader...This is the definitive and authoritative textbook on pediatric psychopharmacology."--Archives of Pediatrics and Adolescent Medicine



Product Details

  • Hardcover: 816 pages
  • Publisher: Oxford University Press, USA; 1 edition (October 17, 2002)
  • Language: English
  • ISBN-10: 0195141733
  • ISBN-13: 978-0195141733
  • Product Dimensions: 11.1 x 8.6 x 1.8 inches
  • Shipping Weight: 5.4 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #1,257,464 in Books (See Top 100 in Books)

 

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12 of 16 people found the following review helpful:
5.0 out of 5 stars Worth it's weight in Aripiprazole, July 31, 2006
This review is from: Pediatric Psychopharmacology: Principles and Practice (Hardcover)
Just follow me for second here: Go back to the dawn of the Cenozoic Era, the Paleocene epoch, 65 million years ago, when the mammalian radiation happened. That was a big deal. And what was it all about? A couple small little animals changed made a major change in their life strategies (actually just the females of the species, the males remain reptilian), which was valuing quality over quantity. Instead of laying tons of eggs, let's make less embryos. But nurture them. Nurture them with all our bodily resources. Let them lay parasitically within us while their brains and other organs mature. Think of it! The emergence of Parenting! Must have been a good idea, within just four million years, mammals radiated stunningly fast, filling the empty ecological niches left by dinosaurs, hoofed mammals achieving a glorious diversity (though still no larger than today's dogs).

So what does that have to do with us? Glad you asked. Not too much until 57 million years ago when our family, the primates, was born. Let's do this: Longer gestation, longer dependencies, bigger brains, better brains.

I'd love to linger on the details, but I have to get around to my point, and reviewing this wonderful, beautiful book. So let's skip to the Pliocene, 5 million years ago, when hominids diverged from our cousins the chimpanzees and bonobos (oh those dirty, dirty bonobos). What made us unique at that point? Three things: 1) Bigger brains. 2) Even longer periods of dependency, with longer infancy, longer toddlerhood, longer latency. All necessary for brains that are too big to be fully developed at birth, with a wider capacity for learned behaviors relative to instinctual behaviors. This, more than ever, necessitates parenting, or at least some kind of nurturing from the older generation to the younger. Which then allows for a greater capacity for culture, shared communal behaviors and beliefs passed down through the generations. And probably helped contribute to uniqueness 3) tool use. Yes, I know other species use tools of a sort, but we've gotten more sophisticated than sticking pruned twigs into termite mounds.

So here we are, human beings. I will refrain from calling us the most evolved species on the planet, since technically everything alive today is equally evolved for its niche (my cat can jump, change directions in mid-air, catch a bird in his mouth. I can't do that but I consistently beat him in backgammon). We are entitled to some species chauvinism, we certainly seem to have the most complex brains on the planet.

The things, then, that make us uniquely human, all converge in the modern medical sub-specialty of child and adolescent psychopharmacology. Using the most sophisticated tools our species have designed to date (psychoactive drugs), we help care for children, help cultivate the potential within the larger, more complex brains of the modern human children. Child Psychiatry is therefore both the leading edge, the ultimate extension of the trajectory of human evolution, as well as also being the most primitive, natural endeavor in medicine, motivated by the most instinctual elements of human character.

Having completed the transition to lower quantity, higher quality offspring, we have extended the dependency of children, and the need for nurturing to it's extreme. So this is our duty, our obligation. Children are vulnerable, and therefore deserve the best efforts of the best among us to help protect and care for them.

This is why treating psychiatrically ill children is the single most intellectually challenging field in medicine. The most stamina-testing, the most ethically challenging, the most emotionally challenging. Children in crisis stir our paternal and/or maternal instincts, and working with them forces us to cultivate our own resilience and stability. There is no better or more important field in medicine right now. Oh sure, let the surgeons continue to preen about the hospital as if their butchery and carpentry skills gives them ownership of the entire field of medicine. Let these barely sublimated sadists have their glory, they certainly seem to need it. Meanwhile, we know who the real brain surgeons are.

So, if we are going to do this, let's do armed and equipped with the best, most accessible information possible. That is why I strongly and unreservedly give this textbook my highest possible recommendation (which, on Amazon, consists of 5 stars, the same recommendation I gave to Blueberry poptarts... Oh well). Children are not just little adults. They have different brains. Different tracts have been myelinated, different nuclei have relatively different densities of receptors, the ratio of cytochrome P450 enzymes differ. Drugs, even when dosage is adjusted for size and metabolism, can have different side effect profiles for children then adults. For mostly obvious ethical and practical reasons, drugs cannot be tested on children as easily and systematically as in adult trials. So we should be very careful when medicating children. But that doesn't mean we shouldn't do it. When diagnoses are made thoughtfully and accurately, medications can be tremendously helpful for children. It can give children their lives back. Some children, able to get their symptoms manageable, find their families interacting different, teachers interact with them different, and their self-confidence can begin to restore itself.

This is a great book, and as of this moment in time, I would say it is the single best comprehensive resource for doctors who are prescribing psychiatric medications to children or adolescents. I'd tell you more about the book but I'm already closing in on 1000 words just trying to convey my passion for the topic. But you get contributions from the best in the field, you have sections devoted to the biological bases of pediatric illness, different diagnoses and different somatic interventions, discussions on other somatic interventions such as complementary and alternative medicines and ECT, and plenty of chapters on assessment and treatment. There is a section on epidemiological, research, and methodological considerations and appendices with quick prescribing information "at a glance." It is a thorough text, worth the price. Even has decent discussions of special populations such as substance abusers, medically ill children, psychopharm during pregnancy, and individuals with MR. Trust me. If you are planning to do a fellowship in child and adolescent psychiatry, or if you are in one of the all too numerous underserved areas where non-specialists find themselves prescribing psychoactive medications to children, you owe it to yourself and to the patients and families you treat to have a copy of this book.
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Inside This Book (learn more)
First Sentence:
THE book's first section is subdivided into three main parts. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
pediatric anxiety disorders, medial prcoptic area, adolescents with depressive disorders, anxicty disorders, opiate substitution therapy, medically ill child, adults with autistic disorder, developmental history questionnaire, lesc psychiatry, manic adolescents, adolescents with schizophrenia, scrotonin syndrome, fear probes, hipolar disorder, adolescents with depression, diatric patients, clozapine response, adults with depression, pediatric psychopharmacology, attentional circuits, tic severity, selective serotonin rcuptake inhibitors, psychotropic treatment, transient sedation, multimodal treatment study
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Arch Gen Psychiatry, United States, American Psychiatric Association, Brain Res, Clin Psychiatry, Biol Psychiatry, Ant Acad Child Adolesc Psychiatry, Cooperative Group, Mol Psychiatry, Acad Sci, Annual Meeting, John Wiley, Psychiatry Res, World Health Organization, Guilford Press, Med Genet, Child Adulesc, National Institutes of Health, Hum Genet, Ann Acad Child, Child Psycho, Anxiety Study Group, Autism Network, Clin North Ant
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