Drew (Martin Henderson), a charming law school student, falls in love with Julia (Piper Perabo) a strong-willed and beautiful co-ed, just two months before their graduation. Not wanting to part ways, Drew impulsively asks Julia, his first real love, to move with him to Los Angeles. Enamored, Julia agrees. Drew quickly adapts to LA living and the two form friendships with their quirky neighbors (Jennifer Tilly and Artie Lange) and a host of outrageous LA characters. But trouble soon finds its way into the couples lives. Drew becomes infatuated with his new job and the Hollywood scene and Julia begins to notice her boyfriends wandering eye. With their relationship at the breaking point the two come to understand that living together has bitter and sweet moments but love is strengthened by experiencing both. An honest, romantic comedy with both hysterical and tender moments, Drew and Julia reaffirm that Perfect Opposites not only attract, but they stick when true love is the glue.