Customer Reviews

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

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This excellent review of PK and PD analysis might be envisioned as a merging of Rowland and Tozer's (clinical) and Gibaldi's resepective textbooks of pharmacokinetics. Although clearly written in support of the WinNonlin (Pharsight) analysis software (the second half of the book includes example models), the text is sufficient as a stand-alone by providing up to date, yet easily understandable and well illustrated discussion of pharmacokinetics. Both modeling and noncompartmental analysis are discussed, as is application of pharmacodynamic analysis. Clinical applicability is included. The book is useful for beginners as well as individuals who have been in the PK/PD business for a while. For myself and my graduate students, the book was particularly helpful in explaining the basis for "policies" followed by many published pharmacokinetic papers.

As someone new to the field, I found this book hard to digest in terms of modeling. I'm trained as a modeler, so I'm hoping to pick up what has been done in the area. However, I found the modeling parts of the books rather slopping. Equations given not telling how they've been derived, worst, approximations are used all the times. You could sometimes guess how the formulae are derived but not the approximations used. After going thru several sections in Chapter 3, I'm skipping the formula ... The mathematics are easy but they are written in such a way that's hard to follow.

I am a beginner of PK/PD modeling. I have found that this book is not for me. I have to make a lot of guess work to figure out how the formulas are derived in this book.