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Pharmacokinetics in Drug Discovery and Development
 
 
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Pharmacokinetics in Drug Discovery and Development [Hardcover]

Ronald D. Schoenwald (Editor)

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Book Description

March 6, 2002 1566769736 978-1566769730 1
Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference.

After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.

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Editorial Reviews

Review

well written, making many of the approaches understandable even if, like me, the reader is not mathematically gifted. Certainly, this section has stimulated my desire to learn more, and like the Clinical Application section, I will be referring to it regularly
- Peter Lawrence, AstraZeneca, UK, BTS Newsletter, Spring 2003

The authors intend to provide a basic understanding and overview of numerous areas within pharmacokinetics...For anyone with a solid initial training in the field, however, this book should function quite well as a refresher on familiar areas and, more to the intended point, as an introduction to subspecialty areas.
-Gregory Reed, PhD, University of Kansas Medical Center

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Inside This Book (learn more)
First Sentence:
Pharmacokinetic processes are broadly defined as absorption, distribution, metabolism, and excretion, giving rise to the frequently used acronym  ADME. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
biotransformed form, drug level predictions, mean time parameters, prospective dosing, biotransformed drug, disposition decomposition analysis, dose tolerance studies, kinetic space, interoccasion variability, bioequivalence criterion, indirect response model, bioequivalence approach, drug concentration response, serum concentration monitoring, lib studies, bolus input, serum concentration measurements, sampling compartment, theophylline serum concentrations, noncompartmental modeling, theophylline disposition, optimal sampling times, theophylline kinetics, population pharmacokinetic model, population pharmacokinetic parameters
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Clinical Pharmacokinetic, Drug Metab, Monte Carlo, Raven Press, Allergy Clin, Marcel Dekker, Thee Drug Monit, United States, Agents Chemother, Drug Dispos, Dual Step Method, Identification of Linearity, Drug Inf, Drug Intell, Applied Therapeutics, Epilepsy Res, Lithium Prospective Dosing, Program Description Operation, American Thoracic Society, Approved Drug Products, Methods Find, National Heart, San Francisco, Therapeutic Equivalence Evaluations
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