First Sentence:
'Clearance' describes the efficiency of irreversible elimination of a drug from the systemic circulation.
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Key Phrases - Statistically Improbable Phrases (SIPs):
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high hepatic extraction ratio drugs, maximum oral bioavailability, renal drug clearance, maintenance dose rate, innovator brand, drug unbound, state drug concentration, fraction unbound, unbound drug concentration, drug concentration increases, filtration clearance, unbound concentration, total drug concentration, intrinsic clearance, drug metabolising enzymes, fraction excreted, plasma drug concentration, liver blood flow, dosing interval, systemic clearance, hepatic blood flow, dosage interval, hepatic clearance, therapeutic drug monitoring, elimination rate
Key Phrases - Capitalized Phrases (CAPs):
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Pharmacokinetics Made Easy, Predicted Renal
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