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Pharmakon [Hardcover]

Dirk Wittenborn (Author)
3.5 out of 5 stars  See all reviews (12 customer reviews)

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Book Description

July 31, 2008
An epic novel about family secrets and the consequences of ambition

William Friedrich, an ambitious professor of psychology at Yale in 1952, has stumbled upon a drug that promises happiness—and that can make him a famous man. When his experiment goes awry, and a research subject commits murder, the consequences will haunt him and his family forever.

Pharmakon is an epic novel, an invocation of the quest for bliss, for love, for family, and all of the betrayals that follow. We follow the Friedrichs from the well-ordered suburban life of postwar America through the chaos and freedom of the counterculture, into the drug-fueled, media-crazed eighties and beyond. In William Friedrich, Wittenborn has defined the archetypal American patriarch: a miracle worker and source of strength to everyone except those he loves the most. Pharmakon is also a layered, thoughtful search behind the veil of psychopharmacology as we know it today—a tale not only of the consequences of research, but also of the complex personalities, appetites, and struggles that created it.

Honest, insightful, and ruefully funny, Pharmakon captures formative moments of the twentieth century, the quirks of an American family, and will enthrall fans of the novels of John Irving.

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Editorial Reviews

From Publishers Weekly

In this ambitious but flawed novel about drug makers and drug takers, Wittenborn (Fierce People) unfurls the cautionary story of Dr. Will Friedrich, a psychopharmacologist at Yale in 1951, who teams up with a female psychiatrist to test an experimental mood-enhancing drug extracted from a leaf used by New Guinea witch doctors. Will tests the new med on a suicidal freshman, Casper Gedsic, and Casper's resulting homicidal outbreak will trouble Will for the rest of his life. Zach, the narrator and youngest Friedrich boy (conceived in the wake of Casper's freakout), comes of age during the tail end of the '60s, has a truncated brush with writerly success and cops a crippling habit. He and his three siblings end up disappointing Will as their lives run counter to his ambitions for them: daughters Fiona and Lucy forgo lucrative careers for more fulfilling lifestyles (Fiona becomes a painter, Lucy an aid worker), and Willy drops out of prelaw to study art. Unfortunately, the fates of the Friedrich children are of much less dramatic interest than that of their father, and as the novel shifts focus to their travails, this dysfunctional family narrative disappointingly peters out into irresolution. (Aug.)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From Booklist

*Starred Review* It is 1951, and Will Friedrich, a young, ambitious, untenured Yale psychology professor is searching for a Big Idea, one that “could make the world a saner place.” Tragically, his big idea turns a geeky freshman genius into a murderer, and the specter of the event haunts Will’s family for 50 years. Pharmakon is a family saga that takes Will, his wife, Nora, and their four children through the watershed moments of five turbulent decades of American history. But it is also a great deal more; by turns, a knowing and slightly jaundiced send-up of academia, a guided tour through some of the worst ideas of twentieth-century medicine and psychology, and an insightful portrait of a brilliant, decent, caring (albeit ambitious) man whose best efforts earn the approval of nearly everyone except those most important to him. Pharmakon is a big book in every way except page count. It is filled with vivid, nuanced characters and with ideas, and Wittenborn’s engaging writing recalls Richard Russo. --Thomas Gaughan

Product Details

  • Hardcover: 416 pages
  • Publisher: Viking Adult (July 31, 2008)
  • Language: English
  • ISBN-10: 0670019429
  • ISBN-13: 978-0670019427
  • Product Dimensions: 9.1 x 6.2 x 1.4 inches
  • Shipping Weight: 1.2 pounds (View shipping rates and policies)
  • Average Customer Review: 3.5 out of 5 stars  See all reviews (12 customer reviews)
  • Amazon Best Sellers Rank: #1,236,839 in Books (See Top 100 in Books)

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Customer Reviews

12 Reviews
5 star:
 (2)
4 star:
 (4)
3 star:
 (4)
2 star:
 (2)
1 star:    (0)
 
 
 
 
 
Average Customer Review
3.5 out of 5 stars (12 customer reviews)
 
 
 
 
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Most Helpful Customer Reviews

6 of 6 people found the following review helpful:
3.0 out of 5 stars An interesting tale that leads nowhere., September 17, 2008
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This review is from: Pharmakon (Hardcover)
This book starts out strong and ultimately fizzles to little more than another tale of a dysfunctional family who blames their father on their lives.

The premise of an ambitious pyschologist/statistical researcher looking to make his mark through the discovery of pyschological pharmaceuticals (in the 50's, long before they became mainstream), and a botched effort which impacts his family, his life and his patients is interesting.

Even the first part of the book holds you in it's grip. The second part is the beginning of the fizzle - and by the end, I felt I had been duped. The story wasn't leading anywhere at all!

I've given it three stars - simply for it's first half. But, I wouldn't recommend reading the whole of it. By the time you get to the end where he wraps up 20 years of a main characters life - in about as many as pages - you know the author, too, couldn't figure out where he'd wanted it to go or what he wanted it to be.
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4 of 4 people found the following review helpful:
2.0 out of 5 stars Promising tale falls to postmodern cliches, September 13, 2008
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This review is from: Pharmakon (Hardcover)
This book starts out with a bang- "I was born because a man came to kill my father." The author then introduces us to his first set of characters- quirky, spirited, intelligent. It's easy to become invested in these characters and to feel curiosity and compassion for them. For this reader, that sense of engagement made it more disappointing than usual when the author decide to pull a John Irving and kill or crush several of his cast members a third of the way through the book. What motivation could he have had? Just avoiding the cliche of satisfying readers with an interesting story? Isn't this sort of narrative hairpin the predominant literary cliche of the last 25 years?
Anyway, the book never regained my interest. Apparently, it never quite regained the author's interest, either for he never tells what the man coming to kill his father had to do with the putative narrator's conception fifteen months later or birth two years after the attempted murder. Just when the second story was growing on me, it was twenty years later and our narrator and his father's best friend are revealed to have been cocaine addicts! And that's not all. A whole bunch of other stupid, implausible events are given exposition which drags this tale to a less than gripping finale without ever answering the points raised by that first promising paragraph. It never resolves the thread of the crazed, dynamic, tortured man who came to kill his father who is somehow almost completely forgotten.
What a disappointment. What a sad waste of time.
I'm sorry I bought it and even sorrier that I finished it.
This is worse than a bad novel.
It's a promising story withheld.
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3 of 3 people found the following review helpful:
2.0 out of 5 stars Frustrating, March 23, 2009
This review is from: Pharmakon (Hardcover)
I don't usually go in for sprawling dysfunctional family dramas, but as I was desperate for an audiobook to keep me company for a long drive, I picked this up. Plus, I had just read one novel about neuropsychopharmacology (Alan Glynn's The Dark Fields), and figured I might as well read another. The story begins and ends will Dr. Will Friedrich, who, as we meet him in 1951, is an untenured junior member of Yale's psychology department with a lovely wife and a houseful of kids to feed. A quantitative wizard with a huge chip on his shoulder, he's barely scraping by as an academic when a fortuitous eavesdropped conversation sparks his collaboration with another Yale outsider.

The first third of the book details their clinical investigation into the antidepressant properties of a tropical psychoactive, while at the same time building up a rich portrait of the Friedrich family and other characters. There are some fine portraits here, such as some Dutch neighbors, Friedrich's blue blood collaborator, and a strangely compelling Hungarian refugee names Lazlo. Another is Casper Gedsic, a brilliant but neurotic Yale freshman whom the Friedrichs befriend and becomes a subject of the clinical trial. Unfortunately, no good deed goes unpunished, and Friedrich's certainty that he can help Casper comes back to haunt the whole family and leave a lasting scar.

The middle of the book finds the family relocated to New Jersey in the late '60s. The father's career has blossomed at Rutgers and as a drug company consultant, and the kids are growing up. Unfortunately, everything becomes more of a domestic drama than the early part of the book, and the life starts too ooze out of the story. We get to know the youngest child, Zach, as he struggles to win his father's respect and his brother Willy's friendship, only to slide all too predictably into a stoner lifestyle (gee, how ironic). While Willy comes into his own as an interesting character, sisters Lucy and Fiona remain ciphers, as does a ridiculous pseudo-hippie love interest "Sunshine."

The story drifts into even further irrelevancy in its final stages, as we leap forward in time to the '80s and '90s, to meet up with those zany Friedrichs again. The four children all have their various colorful issues, but by this point it's difficult to care. Meanwhile, the 75-year-old father is cast as the brilliant but controlling aging patriarch unable to temper knowledge with empathy. This is all well written, but not particularly interesting. All the while, I kept waiting for bogeyman Casper to return at the end to provide some kind of dramatic catharsis. Instead, we an absolute disaster of of a nothing ending. The book's themes, characters, and sheer length demand that the author come to some kind of meaningful climax, but instead there's just a tepid fade to black. This is the most frustrating kind of book, a long one that starts well enough to hook you and keeps you just barely engaged enough to want to see how it all turns out, only to crumble at the end. Possibly worth reading if you're a fan of the dysfunctional American family drama -- but that's about it.
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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
little red hen, tulip moon, fermenting vessel, dissection kit
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Casper Gedsic, The Way Home, Bunny Winton, Will Friedrich, New Haven, New Jersey, Michael Charles, Pep Boys, White Whale, Wainscot Yacht Club, Sleeping Giant, Coach Wyler, Harrison Street, Greenwich Village, Sock Moment, Whitney Bouchard, Old Crow, Sergeant Neutch, Miss Stackhouse, Professor Friedrich, Nina Bouchard, Zach Friedrich, United States, Ivy League
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