Polypeptide and protein drugs are becoming the focus of intense research but many problems are encountered with the synthesis, characterization, formulation and quality control of such drugs. This book provides workers in the field with a comprehensive review of recent developments in polypeptide and protein chemistry and biology relevant to their exploitation as pharmaceuticals. Topics covered include the structure and folding of proteins, polypeptide function, the current status of polypeptide pharmaceuticals, quality control and safety. There is comprehensive discussion of specific peptides including LHRH analogues, insulin, monoclonal antibodies, vaccines and blood glycoproteins.
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