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Power, Sex, Suicide: Mitochondria and the Meaning of Life
 
 
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Power, Sex, Suicide: Mitochondria and the Meaning of Life [Paperback]

Nick Lane (Author)
4.7 out of 5 stars  See all reviews (43 customer reviews)

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Book Description

December 11, 2006
If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria. Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.
In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.
Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

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Editorial Reviews

Review


"Full of startling insights into the nature and evolution of life as we know it."--The Economist


About the Author


Dr. Nick Lane is an honorary senior research fellow at University College, London. His first book, Oxygen: the Molecule that made the World, was published to critical acclaim by Oxford University Press in 2002.

Product Details

  • Paperback: 368 pages
  • Publisher: Oxford University Press, USA (December 11, 2006)
  • Language: English
  • ISBN-10: 0199205647
  • ISBN-13: 978-0199205646
  • Product Dimensions: 7.6 x 4.9 x 0.9 inches
  • Shipping Weight: 9.9 ounces (View shipping rates and policies)
  • Average Customer Review: 4.7 out of 5 stars  See all reviews (43 customer reviews)
  • Amazon Best Sellers Rank: #35,459 in Books (See Top 100 in Books)

More About the Author

Nick Lane is a biochemist and writer. He holds the first Provost's Venture Research Fellowship in the Department of Genetics, Evolution and Environment at University College London. Lane's latest book, Life Ascending, won the Royal Society Prize for Science Books 2010, and his books have been shortlisted for two other literary prizes, named among the books of the year by The Economist, The Independent, The Times and The Sunday Times, and translated into sixteen languages. He is a regular contributor to Nature and New Scientist, and was described by Nobel Laureate Frank Wilczek as "a writer who is not afraid to think big - and think hard." For more information, visit www.nick-lane.net

 

Customer Reviews

43 Reviews
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Average Customer Review
4.7 out of 5 stars (43 customer reviews)
 
 
 
 
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74 of 74 people found the following review helpful:
5.0 out of 5 stars The Penultimate Roots Trip - Eukaryotes, How We Got Here and How We Work, December 14, 2005
After the origin of life, the next big step on the way to us was the origin of eukaryotes. These are all the organisms - including people, trees, mushrooms, and slime molds - who package most of our DNA into chromosomes in cell nuclei. Mitochondria, the "powerhouses" of eukaryotes, are descended from bacteria which took to living in a very close relationship with another type of one-celled organism; in fact they came to live inside the other. Nick Lane argues that this merger must have preceded the formation of the nuclear membrane. Hence "Penultimate Roots Trip".

Lane starts with a brief section on the origin of life, in order to present necessary information about how organisms get usable energy. This strongly supports his claim that something like a mitochondrion is necessary for life to become more complex than bacteria. After that he describes how formerly free-living bacteria could have evolved into the vastly stripped-down mitochondria. Then he builds up a picture of how that partnership led to the complexities of modern organisms. And I really do mean "builds". Each chapter draws on material from earlier chapters, and the picture becomes more complex as you go on. Fortunately, there are frequent recaps of the material you're about to need.

Marvelously, he manages to tell this story in mostly plain English. A little bit of technical language is unavoidable, but I am confident that it will not be a problem for anyone who wasn't already scared off by the word "mitochondrion" in the subtitle.

In addition to power, sex, and suicide, the book also discusses aging. Lane presents his ideas on why current attempts to slow aging don't seem to be working and gives some suggestions for research he finds more promising. This is the culmination of the book and I hope it provokes a lot of thought in readers at all levels of technical knowledge.

[Original review 14 Dec 2005; "powerhouse" comment added 25 Jan 2006.]
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34 of 36 people found the following review helpful:
5.0 out of 5 stars Potentially life changing, January 11, 2006
Few to no equations, not all that many figures, terminology introduced as needed, yet... this book is demanding. It has the capacity to put the reader through the proverbial wringer. It is slow going, not because it is per se difficult to read, but because it brings forth many questions and much thought. When I finish it, I will need to read it again.

It might be worth buying a copy for everyone in the local high school's biology course, in hopes that 2 or 3 people would read it, then be inspired and motivated to study hard toward real science.

How can one not be excited by the quest for a Last Universal Common Ancestor, whether there be one or more? How can one not be fascinated by a reprise on mitochondria, which in (even a very good) high school biology course 36 years ago were too glibly termed "the powerhouse of the cell" (but did we really know much more than this about them)? We now have specific and wonderous mechanisms of energetics, a possibility of discernable origins and history, and a convincing argument for a fundamental and perhaps unique point of departure from the all-microscopic and limited prokaryotic world, toward eukaryotes and rich and complex life.

Lane presents his opinions and speculation in addition to settled science, but these are clearly and responsibly identified. In several instances, opposing views are noted in sufficient detail to allow one to investigate another side of the argument. A Further Reading bibliography cites original journal papers.
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15 of 15 people found the following review helpful:
4.0 out of 5 stars The mighty mitochondria, May 10, 2007
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This review is from: Power, Sex, Suicide: Mitochondria and the Meaning of Life (Paperback)
Nick Lane tops his previous effort ("Oxygen") in gathering the myriad threads of biological science around a unifiying topic. By writing about all complex life forms from the point of view of their embedded mitochondria he answers open questions (and poses some novel ones) about the rise of complex organisms, the underpinnings of sexual reproduction and programmed cell death, and even our odds of encountering extraterrestial intelligence.

My only quibble is that each chapter seems to have been written for serialized publication -- there is too much summary of past chapters at the start of each.

A great read, for an audience spanning a wide range of previous biology studies.
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Inside This Book (learn more)
First Sentence:
Mitochondria are tiny organelles inside cells that generate almost all our energy in the form of ATP. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
eukaryotic merger, leak free radicals, superfluous genes, male mitochondria, hydrogen hypothesis, mitochondrial theory, log metabolic rate, retrograde response, maximal metabolic rate, proton power, death apparatus, maximum metabolic rate, engulfing food, fast metabolic rate, external cell membrane, universal energy currency, archaeal lipids, chondrial genes, multicellular individuals, aerobic scope, fewer free radicals, equivalent mammals, ascending complexity, caspase enzymes, uniparental inheritance
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Lynn Margulis, Bill Martin, Mitochondrial Eve, Peter Mitchell, Stephen Jay Gould, David Keilin, Insider Deal, Max Rubner, New York, Richard Dawkins, Tom Cavalier-Smith, Christian de Duve, John Allen, Mark Ridley, United States
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