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Power, Sex, Suicide: Mitochondria and the Meaning of Life [Paperback]

Nick Lane
4.7 out of 5 stars  See all reviews (59 customer reviews)

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Book Description

December 11, 2006
If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria. Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.

In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.

Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

Frequently Bought Together

Power, Sex, Suicide: Mitochondria and the Meaning of Life + Oxygen: The Molecule that Made the World (Popular Science) + Life Ascending: The Ten Great Inventions of Evolution
Price for all three: $36.78

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Editorial Reviews

Review


"Full of startling insights into the nature and evolution of life as we know it."--The Economist


About the Author


Dr. Nick Lane is an honorary senior research fellow at University College, London. His first book, Oxygen: the Molecule that made the World, was published to critical acclaim by Oxford University Press in 2002.

Product Details

  • Paperback: 368 pages
  • Publisher: Oxford University Press, USA (December 11, 2006)
  • Language: English
  • ISBN-10: 0199205647
  • ISBN-13: 978-0199205646
  • Product Dimensions: 5.1 x 0.8 x 7.5 inches
  • Shipping Weight: 9.1 ounces (View shipping rates and policies)
  • Average Customer Review: 4.7 out of 5 stars  See all reviews (59 customer reviews)
  • Amazon Best Sellers Rank: #66,294 in Books (See Top 100 in Books)

More About the Author

Nick Lane is a biochemist and writer. He holds the first Provost's Venture Research Fellowship in the Department of Genetics, Evolution and Environment at University College London. Lane's latest book, Life Ascending, won the Royal Society Prize for Science Books 2010, and his books have been shortlisted for two other literary prizes, named among the books of the year by The Economist, The Independent, The Times and The Sunday Times, and translated into sixteen languages. He is a regular contributor to Nature and New Scientist, and was described by Nobel Laureate Frank Wilczek as "a writer who is not afraid to think big - and think hard." For more information, visit www.nick-lane.net

Customer Reviews

Well written and very interesting. Schmander  |  17 reviewers made a similar statement
This is one of the most interesting and informative books I've ever read. Steven C. West  |  13 reviewers made a similar statement
Most Helpful Customer Reviews
87 of 88 people found the following review helpful
Format:Hardcover
After the origin of life, the next big step on the way to us was the origin of eukaryotes. These are all the organisms - including people, trees, mushrooms, and slime molds - who package most of our DNA into chromosomes in cell nuclei. Mitochondria, the "powerhouses" of eukaryotes, are descended from bacteria which took to living in a very close relationship with another type of one-celled organism; in fact they came to live inside the other. Nick Lane argues that this merger must have preceded the formation of the nuclear membrane. Hence "Penultimate Roots Trip".

Lane starts with a brief section on the origin of life, in order to present necessary information about how organisms get usable energy. This strongly supports his claim that something like a mitochondrion is necessary for life to become more complex than bacteria. After that he describes how formerly free-living bacteria could have evolved into the vastly stripped-down mitochondria. Then he builds up a picture of how that partnership led to the complexities of modern organisms. And I really do mean "builds". Each chapter draws on material from earlier chapters, and the picture becomes more complex as you go on. Fortunately, there are frequent recaps of the material you're about to need.

Marvelously, he manages to tell this story in mostly plain English. A little bit of technical language is unavoidable, but I am confident that it will not be a problem for anyone who wasn't already scared off by the word "mitochondrion" in the subtitle.

In addition to power, sex, and suicide, the book also discusses aging. Lane presents his ideas on why current attempts to slow aging don't seem to be working and gives some suggestions for research he finds more promising. This is the culmination of the book and I hope it provokes a lot of thought in readers at all levels of technical knowledge.

[Original review 14 Dec 2005; "powerhouse" comment added 25 Jan 2006.]
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35 of 39 people found the following review helpful
5.0 out of 5 stars Potentially life changing January 11, 2006
Format:Hardcover
Few to no equations, not all that many figures, terminology introduced as needed, yet... this book is demanding. It has the capacity to put the reader through the proverbial wringer. It is slow going, not because it is per se difficult to read, but because it brings forth many questions and much thought. When I finish it, I will need to read it again.

It might be worth buying a copy for everyone in the local high school's biology course, in hopes that 2 or 3 people would read it, then be inspired and motivated to study hard toward real science.

How can one not be excited by the quest for a Last Universal Common Ancestor, whether there be one or more? How can one not be fascinated by a reprise on mitochondria, which in (even a very good) high school biology course 36 years ago were too glibly termed "the powerhouse of the cell" (but did we really know much more than this about them)? We now have specific and wonderous mechanisms of energetics, a possibility of discernable origins and history, and a convincing argument for a fundamental and perhaps unique point of departure from the all-microscopic and limited prokaryotic world, toward eukaryotes and rich and complex life.

Lane presents his opinions and speculation in addition to settled science, but these are clearly and responsibly identified. In several instances, opposing views are noted in sufficient detail to allow one to investigate another side of the argument. A Further Reading bibliography cites original journal papers.
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17 of 17 people found the following review helpful
4.0 out of 5 stars The mighty mitochondria May 10, 2007
Format:Paperback|Amazon Verified Purchase
Nick Lane tops his previous effort ("Oxygen") in gathering the myriad threads of biological science around a unifiying topic. By writing about all complex life forms from the point of view of their embedded mitochondria he answers open questions (and poses some novel ones) about the rise of complex organisms, the underpinnings of sexual reproduction and programmed cell death, and even our odds of encountering extraterrestial intelligence.

My only quibble is that each chapter seems to have been written for serialized publication -- there is too much summary of past chapters at the start of each.

A great read, for an audience spanning a wide range of previous biology studies.
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Most Recent Customer Reviews
5.0 out of 5 stars Eye-opener
This book is just fantastic! If you like the topic, the book is not difficult to follow for non-scientists, and it is just an amazing view of our own biology. Read more
Published 28 days ago by Isidro Rodriguez
5.0 out of 5 stars Anyone can read this and be amazed at why life is
From a geologists point of view, it was a great introduction to some of the basics of why biology , as in life, works, and spent a few weeks having a great read. Read more
Published 1 month ago by ANTONY D. FORD
5.0 out of 5 stars Understanding Life
Nick Lane, very good writer, a fascinating look at how the human body runs. This book and his book on Oxygen,
should be read by all.
Published 1 month ago by E. Edward Williams
5.0 out of 5 stars Astounding!
I am totally blown away by the totality of the authors approach to the very dense subject material.The material covered require a complete and comprehensive overview before the... Read more
Published 2 months ago by Mrpres16
5.0 out of 5 stars Charge on, Mighty Chondria!
I am deeply interested in the mysteries of the mitochondria and MD (Mito Diseases). Most of the academic works on the subject are fairly arcane and focus on the cutting edge of... Read more
Published 2 months ago by Curious
5.0 out of 5 stars Worth the time and effort.
Power, Sex, Suicide:Mitochondria and the meaning of life

An extraordinarily brilliant and eloquent work about one of the great revolutionary insights into biology as it... Read more
Published 4 months ago by S P Hersh
5.0 out of 5 stars An astonishing accomplishment!
Nick Lane has a rare talent for explaining incredibly complex topics from a broad range of scientific disciplines. Read more
Published 4 months ago by Gary Wenk, Ph.D. Professor of Psychology & Neuroscience
5.0 out of 5 stars What Came First, the Chicken or the Egg?
I've been interested in biology and evolution since I was a kid so this book really fit the bill. The mystery of the mitochondria and complex life was one of the main themes of my... Read more
Published 6 months ago by LastRanger
5.0 out of 5 stars who cares about mitochondria anyway!
Power, Sex, Suicide is one of the best books I have ever read. It is an amazing synthesis of ideas and facts and research and conclusions about the origin of you and me. Read more
Published 7 months ago by Dr. R. Santore
5.0 out of 5 stars Mitochondria is the reason
Mitochondria is the reason there are no prokaryotic mice. If we calculate the actual measured energy per gene in prokaryotes and
eukaryotes of similar size, taking into... Read more
Published 9 months ago by Ana Ruiz
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