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Practical Process Research & Development [Hardcover]

Neal G. Anderson (Author)
5.0 out of 5 stars  See all reviews (3 customer reviews)

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There is a newer edition of this item:
Practical Process Research and Development - A guide for Organic Chemists, Second Edition Practical Process Research and Development - A guide for Organic Chemists, Second Edition
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Book Description

April 3, 2000 0120594757 978-0120594757 1
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine
chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key
compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are
identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and
academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent,
and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

* Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"
* Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more
* Includes over 100 tips for rapid process development
* Presents guidelines for implementing and troubleshooting processes


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Practical Process Research & Development + Crystallization of Organic Compounds: An Industrial Perspective + Process Development: Fine Chemicals from Grams to Kilograms (Oxford Chemistry Primers)
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Editorial Reviews

Review

"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department."
--Sean T. Nugent, Searle Research & Development
"Practical Process Research & Development is just that, practical... Especially enjoyable are author Neal G. Anderson's pithy 'tips'... Fun chemistry throughout."
--CHEMICAL INNOVATION. June 2000
"The new volume by Dr. Anderson ranks with the very best on the subject covering almost all aspects of process research and development and scale up in an informative and readable manner. ...the many "Tips" given throughout the book are practical and informative and should be mandatory reading for all synthetic organic chemists, including those in research and discovery. ...could well become a standard text on the subject. Indeed, it is my recommendation that Process Chemistry departments throughout the industry buy two copies, one for themselves and one to help educate their colleagues in research/discovery. Many of the topics covered and the tips given in the book could also be of great use to anyone organizing organic chemistry practical courses for students. Perhaps the highest praise one can give this book is to say that Foreword by Barry Sharpless raises very high expectations and the book meets and at times exceed those expectations."
--ORGANIC PROCESS RESEARCH & DEVELOPMENT, Vol.4, No.5, 2000
"Following enthusiastic Forwards by Barry Sharpless and Jerry Moniot, each chapter of the book addresses commonly encountered aspects of large-scale synthesis. Drawing extensively from literature case studies for illustration, Anderson also sprinkles useful tips throughout the text, while his use of lists, tables, and charts aids in reinforcing key concepts.
The text readily succeeds as a highly practical tour throughout the considerations of chemical scale-up.
Newly minted chemists will find this a valuable introductory text, while veteran researchers will also glean much from Anderson's extensive experience. The book can easily be recommended as a reading for a graduate organic synthesis course. Medicinal chemists may find this trove of practical synthetic know-how quite useful in their drug discovery programs. Certainly all readers will better appreciate the challenges faced by process chemists in bringing a compound through development and commercialization."
--Christopher R. Schmid, Senior Research Scientist, Lilly Research Laboratories, Eli Lilly and Company, JOURNAL OF MEDICINAL CHEMISTRY, 2001, Vol. 44, No.7
"In summary, we believe that every newcomer to the exciting field of process research and development should read this book, but also experienced process chemists and even academics will find it very useful and stimulating. As the language of stock analysts and brokers is very popular today, we recommend Practical Process Research and Development, by Neal G. Anderson, as a "strong buy" because this investment will pay off very quickly."
--ANGEWANDTE CHEMIE, 2001, 40, No. 7.
"...Filled with valuable insights and personal experience.... Dr. Anderson's book is indeed the best text on process development available to organic chemists. I have bought several for my group."
--ADVANCED SYNTHESIS & CATALYSIS, 2001, Oljan Repic, Director of Process R&D, Novartis Institute for Biomedical Research

Book Description

Foreword by K. Barry Sharpless, The Scripps Research Institute, La Jolla, CA and Dr. Jerome Moniot, Bristol-Myers Squibb

Product Details

  • Hardcover: 354 pages
  • Publisher: Academic Press; 1 edition (April 3, 2000)
  • Language: English
  • ISBN-10: 0120594757
  • ISBN-13: 978-0120594757
  • Product Dimensions: 9.1 x 6.1 x 0.6 inches
  • Shipping Weight: 1.1 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (3 customer reviews)
  • Amazon Best Sellers Rank: #846,689 in Books (See Top 100 in Books)

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Average Customer Review
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5.0 out of 5 stars For industrial R&D chemists, January 1, 2012
By 
Imagine you have many "old-timers" giving out practical tips each from years of experience. That is not often happening. This book does exactly that.

It addresses process R&D in pharmaceutical and / or fine chemicals industry, taking one from laboratory bench to pilot or production scale. The differences and difficulties in scale-up were clearly demonstrated and the solutions provided. It educates and helps a R&D chemist or process chemist to ANTICIPATE, AVOID and OVERCOME the potential problems in process development and scale-up, at the START or EARLY stage of the project. Supported by many examples, the best practices and solutions are presented at the detailed technical level: routes, reagents, solvents, water, running and optimizing reactions, workup, chiral synthesis, etc.

The author highlighted a lot of key advice in "boxes" and allows a quick one-hour read of the best points.
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5.0 out of 5 stars The Editorial reviews say it all, November 17, 2011
This review is from: Practical Process Research & Development (Hardcover)
I read this book cover to cover, come back to it many times. No other process chemistry book teaches better than this one. Highly recommended.
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2 of 5 people found the following review helpful:
5.0 out of 5 stars Magic !!!, February 8, 2008
This review is from: Practical Process Research & Development (Hardcover)
If you ever wonder how to run your reaction on a three tons scale, this is one of the books to go for. On the top it is also real fun to read.
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Inside This Book (learn more)
First Sentence:
The cost and pace of developing active compounds for the pharmaceutical and agricultural industries is dramatically increasing. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
kilo lab, crystallization pressure, gallon reactor, salen catalyst, rework procedures, process chemist, impurity formation, new impurities, quench solution, reaction aliquot, reaction streams, wet cake, resolving agent, drug substance, colored impurities, extended processing, wash solvent, rich extract, peptide coupling
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Process Res, Tetrahedron Lett, Marcel Dekker, New York, Academic Press, American Chemical Society, San Diego, Choosing Solvents, Karl Fischer, Azeotropic Data, Pharmaceutical Solids, Process Chemistry, Protease Inhibitor, Monopril Intermediate, Receptor Antagonist, The Third International Conference, Trimethylsilyl-Modified Arbuzov Reaction, Addison Wesley Longman, Chiral Induction, United States, Aldrich Chemical Company, Amelia Island, Analytical Profiles of Drug Substances, Chemistry Series, Efficient Synthesis of Losartan
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