The metabolic disorder phenylketonuria (PKU) is the most common biochemical cause of mental retardation, and affects roughly one in 10,000 children. Bridging basic neuroscience research and clinical studies, this longitudinal study (a) provides evidence that cognitive deficits result from even moderate amino acid imbalances considered acceptable under the standard treatment for PKU, (b) characterizes the nature of those cognitive deficits, and (c) identifies their biological cause. The authors discuss possible steps to correct the problem, and possible implications of the findings for children with other developmental disabilities, such as attention deficit disorder.
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We report here the results of a 4-year longitudinal study designed to investigate cognitive neuropsychological functioning in children who we hypothesized would have a selective loss of dopamine in prefrontal cortex without other abnormalities in the brain. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
three pegs task, times normal performed, boxes remain stationary, cognitive testing session, second practice trial, spatial processing task, children from the general population, visual paired comparison task, inhibitory control functions, consecutive reaches, inhibitory control abilities, required working memory, temporal order memory, higher performed, object retrieval task, other subject groups, box containing the toy, confirmation trial, four comparison groups, retrieval trials, habituation criterion, spatial discrimination task, preceding testing, level during first year, boxes task Key Phrases - Capitalized Phrases (CAPs): (learn more)
Sex Differences There, Groups Analyzed Separately There, New Jersey, None None None None, United States New!
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Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
We report here the results of a 4-year longitudinal study designed to investigate cognitive neuropsychological functioning in children who we hypothesized would have a selective loss of dopamine in prefrontal cortex without other abnormalities in the brain. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
three pegs task, times normal performed, boxes remain stationary, cognitive testing session, second practice trial, spatial processing task, children from the general population, visual paired comparison task, inhibitory control functions, consecutive reaches, inhibitory control abilities, required working memory, temporal order memory, higher performed, object retrieval task, other subject groups, box containing the toy, confirmation trial, four comparison groups, retrieval trials, habituation criterion, spatial discrimination task, preceding testing, level during first year, boxes task Key Phrases - Capitalized Phrases (CAPs): (learn more)
Sex Differences There, Groups Analyzed Separately There, New Jersey, None None None None, United States New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
Citations (learn more)
This book cites 19
books:
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- Guided Participation in Cultural Activity by Toddlers and Caregivers (Monographs of the Society for Research in Child Development) by Barbara Rogoff in Back Matter
- Language Comprehension in Ape and Child (Monographs of the Society for Research in Child Development) by E. Sue Savage-Rumbaugh in Back Matter
- Self-Evaluation in Young Children (Monographs of the Society for Research in Child Development) by Deborah Stipek in Back Matter
- What Young Chimpanzees Know about Seeing (Monographs of the Society for Research in Child Development) by Daniel J. Povinelli in Back Matter
- Developmental Neuropsychology by Otfried Spreen in Back Matter
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