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  • Prilosec OTC Acid Reducer, Delayed-Release Tablets, 42 Count Package
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Prilosec OTC Acid Reducer, Delayed-Release Tablets, 42 Count Package

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List Price: $37.84
Price: $19.99 ($0.48 / count) & FREE Shipping
You Save: $17.85 (47%)
In Stock.
Ships from and sold by Bargain Club.
42 Count
  • One package of 42-count acid reducer delayed release tablets
  • Targets acid production by directly shutting down many active acid pumps; a single pill works for up to 24 hours
  • Delayed-release acid-reducing tablets for treating frequent heartburn
  • Designed for heartburn that occurs two or more days per week
  • Not intended for immediate relief; may take 1 to 4 days for full effect
71 new from $14.88


Frequently Bought Together

Prilosec OTC Acid Reducer, Delayed-Release Tablets, 42 Count Package + Keurig, Green Mountain Coffee, Dark Magic, K-Cup packs 72 Count + Keurig The Original Donut Shop K-Cup Packs, Regular, 72 Count
Price for all three: $103.86

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Important Information

Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Please see our full disclaimer below.

Product Description

Flavor: Regular | Size: 42 Count

From the Manufacturer

Since the beginning, we’ve led the way in OTC frequent heartburn treatments. We were first on the market and have continued to provide relief to heartburn sufferers with our trusted formula. For nearly 5 years now, Prilosec OTC has been in the strongest class of one-pill-a-day heartburn medicine available over the counter.

Product Features

Proven Strength for Heartburn Relief
Keep Heartburn from Coming Back while Taking Prilosec OTC
Prilosec OTC is strong enough to fight heartburn before it begins. It’s the only over-the-counter PPI (proton pump inhibitor) clinically proven to block heartburn for 24 hours.
And that means with 1 pill a day for 14 days, you get the relief you need from the pain of frequent heartburn.* And, while taking Prilosec OTC, heartburn won’t keep coming back.

In a recent study, we tested the strength of Prilosec OTC against frequent heartburn. Take a look at the results:

78% of consumers were heartburn free on the first night
81% of consumers had complete relief*/only mild symptoms on day one
94% of consumers were satisfied with how well Prilosec OTC worked

See for yourself if Prilosec OTC is right for you.

*It’s possible with Prilosec OTC. Use as directed for 14 days for treating frequent heartburn

Why Prilosec OTC Is Different

As the first over-the-counter proton pump inhibitor (PPI), Prilosec OTC is different from many other heartburn treatments and medications. Here’s a quick breakdown:
PPI (Proton Pump Inhibitor)

When you eat, millions of tiny pumps in your stomach produce acid to break down food — heartburn occurs when these excess acids reflux into your esophagus. Prilosec OTC works by directly blocking many of these pumps. Your stomach produces enough acid to digest food, but reduces excess acid — making it the most effective heartburn treatment choice and the #1 doctor recommended OTC acid reducer. Prilosec OTC blocks heartburn for 24 hours with one pill a day.*


Antacids neutralize the acid in your stomach. Unlike the proactive PPI, antacids are commonly taken after you eat or when pain begins. While no heartburn treatments cure the condition, antacids provide only temporary relief.

H2 Blockers

H2 Blockers relieve heartburn symptoms by reducing the acid production. They begin working within an hour and last for 12 hours. H2 Blockers are not as effective in treating severe heartburn as PPIs.

*It’s possible with Prilosec OTC. Use as directed for 14 days for treating frequent heartburn.

Wolters Kluwer (Acid reducer category).

Read Our Package

Drug Facts

Active ingredient (in each tablet)

Omeprazole magnesium delayed-release tablet 20.6 mg

(equivalent to 20 mg omeprazole)


Acid reducer

  • treats frequent heartburn (occurs 2 or more days a week)
  • not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect

Allergy alert: Do not use if you are allergic to omeprazole

Do not use if you have trouble or pain swallowing food, vomiting with blood, or bloody or black stools.

These may be signs of a serious condition. See your doctor.

Ask a doctor before use if you have

  • had heartburn over 3 months. This may be a sign of a more serious condition.
  • heartburn with lightheadedness, sweating or dizziness
  • chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness
  • frequent chest pain
  • frequent wheezing, particularly with heartburn
  • unexplained weight loss
  • nausea or vomiting
  • stomach pain

Ask a doctor or pharmacist before use if you are taking

  • warfarin (blood-thinning medicine)
  • prescription antifungal or anti-yeast medicines
  • diazepam (anxiety medicine)
  • digoxin (heart medicine)
  • tacrolimus (immune system medicine)
  • atazanavir (medicine for HIV infection)

Stop use and ask a doctor if

  • your heartburn continues or worsens
  • you need to take this product for more than 14 days
  • you need to take more than 1 course of treatment every 4 months

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

  • adults 18 years of age and older
  • this product is to be used once a day (every 24 hours), every day for 14 days
  • it may take 1 to 4 days for full effect, although some people get complete relief of symptoms within 24 hours
  • children under 18 years of age: ask a doctor

14-Day Course of Treatment

  • swallow 1 tablet with a glass of water before eating in the morning
  • take every day for 14 days
  • do not take more than 1 tablet a day
  • do not chew or crush the tablets
  • do not crush tablets in food
  • do not use for more than 14 days unless directed by your doctor

Repeated 14-Day Courses (if needed)

  • you may repeat a 14-day course every 4 months
  • do not take for more than 14 days or more often than every 4 months unless directed by a doctor
Other information
  • read the directions, warnings and package insert before use
  • keep the carton and package insert. They contain important information.
  • store at 20-25°C (68-77°F)
  • keep product out of high heat and humidity
  • protect product from moisture

Inactive ingredients glyceryl monostearate, hydroxypropyl cellulose, hypromellose, iron oxide, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, paraffin, polyethylene glycol 6000, polysorbate 80, polyvinylpyrrolidone, sodium stearyl fumarate, starch, sucrose, talc, titanium dioxide, triethyl citrate

Product Description

Prilosec OTCTM omeprazole delayed-release tablets 20mg/acid reducer

Product Details

Flavor: Regular | Size: 42 Count
  • Product Dimensions: 2.3 x 4.8 x 3.7 inches
  • Shipping Weight: 0.3 ounces (View shipping rates and policies)
  • Shipping: Currently, item can be shipped only within the U.S.
  • Origin: India
  • ASIN: B0000AN9L7
  • UPC: 003700035907 037000264897 037000359074 037000270041
  • Item model number: OTC
  • Average Customer Review: 4.6 out of 5 stars  See all reviews (682 customer reviews)
  • Amazon Best Sellers Rank: #104 in Health & Personal Care (See Top 100 in Health & Personal Care)
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Customer Questions & Answers

Customer Reviews

Great pricing and product.
Don't stop taking it until you give it a chance to work, or you'll be missing out on this drug that can make your life infinitely better.
I highly recommend this product to anyone who suffers acid reflux or chronic heartburn.
Scott Pointon

Most Helpful Customer Reviews

93 of 100 people found the following review helpful By Amazon Customer on December 21, 2003
Flavor Name: RegularSize Name: 42 Count Verified Purchase
This is one of the top money-making drugs of all time, and for good reason. It works. I used to have pretty bad acid reflux. I would chew Pepcid Complete (which is an antacid drug combined with a base to neutralize acid) after every meal, as if they were after-dinner mints. Now, I just take Prilosec once a day, and now I almost never suffer from heartburn, and when I do, it is not as bad as it used to be. Trust me on this. This drug works differently than Pepcid or Zantac (I have a Ph.D in biology), so if those drugs don't work for you, don't be afraid to give this a try.
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74 of 82 people found the following review helpful By Modern Blue Argonaut on December 20, 2006
Flavor Name: RegularSize Name: 42 Count Verified Purchase
I have been a Prilosec user for about four years now. In the past, I would do the 2 week recommended period, then stop for a couple of weeks, and continue that cycle. My acid reflux never got any better except on the days I took the Prilosec. The day I would stop it would be right back. Finally, I found out that most people take it as a maintenace medication, so I started taking it once a day without fail and my acid reflux was finally gone forever! I used to wake up all night long with severe esophageal pain, sometimes vomiting right in bed from all the acid. It was such a nightmare. I would end up taking a half bottle of tums which still wouldn't work, and sleep sitting up. I tried every over the counter medication out there with no relief at all until Prilosec. It truly is a miracle drug. For those of you out there with acid reflux, don't suffer any longer! Try this and give it about 3 days to start working, and you will be able to turn your sleep and your life around. Amazon often has specials such as spend $49 on groceries (this qualifies) and get $10 off your order. By all means, double up on Prilosec and do this.... I am now 2 years acid reflux free! It's not so bad, if I miss a day now, I don't suffer at all.
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57 of 67 people found the following review helpful By kone TOP 500 REVIEWER on October 6, 2005
Flavor Name: RegularSize Name: 42 Count
For those that suffer with frequent heartburn or have frequent instances of gastric reflux, Prilosec is a literal lifesaver.

Stomach acid is strong stuff (pH of 1), and belongs in the stomach, not in the esophagus, where it can cause burning of the esophageal lining (hertburn). If this happens frequently, the esophagus can be badly damaged. Gastro-esophageal Reflex Disease (GERD)can also cause severe erosive damage to the teeth if stomach acid is burped into the mouth frequently. The tooth enamel is literally eroded away, and teeth become very sensitive and permanently damaged.

To save your teeth and esophagus, Prilosec has come to the rescue. Prilosec is a former prescription product in a class of medicines called proton pump inhibitors. This means that the effect of Prilosec is to decrease stomach acid production. This is also beneficial for treatment of stomach ulcers, which need a minimal acid environment to heal.

Prilosec is taken once a day for 14 days in a typical course (thus, it is generally packaged in groups of 14 tablets). Most people have considerable relief beyond the 14 day course. It is not a product to take for immediate (within minutes) treatment of heartburn. The insert on the box states it takes at least a day to 4 days to reach its full effect. Each person will vary in terms of relief and how long the relief lasts.

Prilosec is a very good medicine for the treatment of GERD. It is in the same class as Prevacid, so if Prilosec gives you undesirable side effects, try Prevacid and the side effects may be lessened.

Jim "Konedog" Koenig, Dentist
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16 of 19 people found the following review helpful By The Network Engineer on February 10, 2014
Flavor Name: RegularSize Name: 42 Count Verified Purchase
Just wanted to provide my results and feedback. I've been taking Prilosec since 2005 and was in my mid 20's then. I started when I got frequent heart burn and went to see a doctor. Instead of actually taking the time and diagnosing the real issue He prescribed me Prilosec. I took it for years and never questioned it. Fast forward to 2011 my wife began getting concerned and stating I shouldn't take this pill for ever and asked me to see a Gastroenterologist. I Scheduled an appointment and had a endoscopy done. Post endoscopy test showed nothing abnormal, no hernia or anything. The doctor said if Prilosec is working keep taking it (my wife was shocked). I tried getting off the 1 a day pill several times with failure because the intense heartburn I got which I later found out was rebound from the drug. Starting September 2013 I tried again with more research and better approach. I began by reducing the amount of Prilosec from 1 a day to ¾ for 1 week then to ½ for week. After 3 weeks I used Tagment and Pepcid AC frequently to treat the rebound created by Prilosec. It was extremely painful and I’d wake up frequently at night with massive heartburn. I begin taking a Probiotic enzyme with every meal and Now Foods Betaine HCl. This worked for several months while I tried to wean myself off the Pepcid AC and Tums popping. . I tried everything from DGL to heartburn stop. It appears the rebound lasted 4-5 months. This might be due to me being on the pill for years. Now in Feb 2014 I am not having to take any enzyme or probiotic. I also began exercising early January and began eating healthier. I’ve lost 13 lbs. I did not consider myself fat either since I frequent the gym to lift weights 3-4 times a week. I’ve cut out eating out (Both restaurants and fast food) and my energy is great and no heartburn.Read more ›
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Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. assumes no liability for inaccuracies or misstatements about products.