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A Primer of Genome Science, 2nd Edition [Paperback]

Greg Gibson , Spencer V. Muse
4.4 out of 5 stars  See all reviews (5 customer reviews)

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Book Description

December 2004 0878932321 978-0878932320 2
A Primer of Genome Science bridges the gap between standard genetics textbooks and highly specialized, technical, and advanced treatments of the subdisciplines. It provides an affordable and up-to-date introduction to the field that is suited to advanced undergraduate or early graduate courses. Bioinformatic principles and experimental strategies are explained side-by-side with the experimental methods, establishing a framework that allows teachers to explore topics and the literature at their own pace.

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Editorial Reviews


"...remarkably comprehensive & organized given its length, covering most model organisms & many new & emerging techniques " -- Mark Lubkowitz, BioScience --This text refers to an out of print or unavailable edition of this title.

About the Author

GREG GIBSON, North Carolina State University. - SPENCER MUSE, North Carolina State University. --This text refers to an out of print or unavailable edition of this title.

Product Details

  • Paperback: 378 pages
  • Publisher: Sinauer Associates Inc; 2 edition (December 2004)
  • Language: English
  • ISBN-10: 0878932321
  • ISBN-13: 978-0878932320
  • Product Dimensions: 0.8 x 6.7 x 8.9 inches
  • Shipping Weight: 1.6 pounds
  • Average Customer Review: 4.4 out of 5 stars  See all reviews (5 customer reviews)
  • Amazon Best Sellers Rank: #1,656,371 in Books (See Top 100 in Books)

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Customer Reviews

4.4 out of 5 stars
4.4 out of 5 stars
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Most Helpful Customer Reviews
15 of 16 people found the following review helpful
By A Customer
This somewhat understated book may be overlooked based on its title, and yet it represents the best book currently in print to provide a solid overview of the science and issues in genome science, functional and structural genomics, and the subdiscipline proteomics. Chapter 1 describes current progress with mapping genomes, including the human genome and other genomes in plants and animals. Chapter 2 describes sequencing approaches and gene identification. Chapter 3 deals with gene expression and technologies. Chapter 4 focuses on proteomics including brief introductions to 2D-PAGE and mass spectrometry. This chapter also briefly introduces the reader to structural genomics, or the prediction of protein structure based on sequence through threading and modeling. After a chapter on single nucletide polymorphisms and genotyping the book concludes with a chapter on integrating genome studies including the use of in silico approaches.
Although scant in detail in parts, a major strength of the book is the wide coverage given to science of genomics and its offshoots. Overall an excellent course text for undergraduate or early postgraduate students or others interested in these emerging disciplines. I am not aware of any competing texts which such coverage and certainly not at the price of this one.
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2 of 3 people found the following review helpful
Every technician and/or PI should own a copy of this text for their lab. With the logical diagrams and full explanation of the text, this book is really condensed and assumes some knowledge of molecular biology. This book does not assume knowledge of genomics, but rather serves as a manual.
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5.0 out of 5 stars Up to Date and Very Well Done August 10, 2005
With the basic science being so new and changing so rapidly, this second edition is timely and welcome. Virtually every chapter has been re-written to bring it up to date. The result is a text suitable for use in upper under grad or beginning grad level course in functional genomics or bioinformatics. The six chapter headings are:

Genome Projects: Organization and Objectives

Genome Sequencing and Annotation

SNPs and Variation

Gene Expression and the Transcriptome

Proteomics and Functional Genomics

Integrative Genomics.

The book is well written and profusely illustrated with color drawings and photographs. The book is closely allied with the web in form of accessable databases and the like which may keep it from going out of date so fast.

With most text books being so expensive, this book is a definite sleeper in the field.
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2 of 4 people found the following review helpful
3.0 out of 5 stars Poorly Written, Good graphics January 9, 2004
By A Customer
The book is very poorly written and is too difficult to follow to be called a "primer." Authors often focus on actual software tools and how to use them rather than the science behind them.
To be fair, the graphics offered in the book are excellent and sometimes are the only way to understand a difficult concept.
The preface says to be familiar with "the content of a typical 300 level undergraduate course in genetics" -- it should be a definite prerequisite for reading this book.
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0 of 1 people found the following review helpful
5.0 out of 5 stars good for beginner May 11, 2010
By JJ You
Except the computer-aided drug design, this book covers all the basic theory and useful information of bioinformatics. I recommended this book for anyone who needs to use the bioinformatics web, software tools. For the clinical physician, medical student, and molecular biology scientist, this book is very useful. Especially when you have no time to understanding the detail mathematic calculation, it quickly gives you a whole view and introduction.
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