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Principles and Practice of Skin Toxicology
 
 
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Principles and Practice of Skin Toxicology [Hardcover]

Robert Chilcott (Editor), Shirley Price (Editor)

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Book Description

0470511729 978-0470511725 October 28, 2008 1
Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology.
  • Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. 
  • A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements.
  • A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. 
  • Includes a chapter on drug delivery through the skin.
  • Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

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Editorial Reviews

Review

"This is a very useful book for students or toxicologists who want to familiarize themselves with the specific subdiscipline of ermatoxicology, and with the currently validated methods of the trade. The fact that the book is easy to read with a logical story line makes it suitable for students." (BTS Newsletter, Summer 2009)

From the Back Cover

Written by experts in the field, Principles and Practice of Skin Toxicology provides a “bottom up” approach to studying skin toxicology. It provides a clear outline of basic concepts, citing both historical and modern references, and contains a glossary of key terms for quick and easy reference. 

Arranged in a user friendly and logical sequence, the book covers the five main areas of dermatotoxicology:

  • Principles of skin absorption. Explains the factors influencing dermal absorption and associated methods of measurement.
  • Methods for assessing skin toxicity. An overview of both in vivo and in vitro approaches to testing, with particular emphasis on the validation and use of alternative test strategies.
  • Clinical and occupational skin toxicity. A basic introduction to dermatology and related applications central to understanding dermal exposure to chemicals.
  • Regulatory aspects.  An overview of national and international legislation governing the safe marketing of pharmaceuticals, cosmetics and industrial chemicals.

This book will be especially useful to scientists who are new to the area of dermal toxicology, as well as practitioners of toxicology, clinical researchers, and researchers in industry and academia.


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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
primary learning objectives, test guideline, skin pharmacology, vitro skin absorption studies, phototoxic hazard, red uptake phototoxicity test, vitro tests for skin corrosion, skin absorption kinetics, receptor chamber fluid, occupational skin exposures, vitro phototoxicity assays, vitro phototoxicity testing, skin corrosivity testing, sensitisation testing, sensitising chemicals, skin cytosol, occupational skin disorders, dermal toxicology, pig maximisation test, skin microsomes, skin sensitisers, skin sensitisation, dermal toxicity studies, prevalidation study, hair dye formulation
Key Phrases - Capitalized Phrases (CAPs): (learn more)
European Union, Journal of Investigative Dermatology, Cosmetics Directive, Boca Raton London New York, John Wiley, United Kingdom, Arch Dermatol, Invest Dermatol, Scientific Committee, Control of Substances Hazardous, Bioengineering of the Skin, Dangerous Substances Directive, Non-irritant Code, Biochemical Pharmacology, Acta Derm Venereol, Toxicol Sci, Council Directive, Springer Verlag, Journal of Biological Chemistry, University of Newcastle, Toxicological Sciences, Photochem Photobiol, European Cosmetic Industry, Pharm Res, European Commission
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Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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