Principles of Tissue Engineering, Second Edition [Hardcover]

Robert Lanza (Editor), Robert Langer (Editor), Joseph P. Vacanti (Editor)

Book Description

ISBN-10: 0124366309 | ISBN-13: 978-0124366305 | Publication Date: May 18, 2000 | Edition: 2

The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.

Key Features
* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves
* Essential to anyone working in the field
* Educates and directs both the novice and advanced researcher
* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves
* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell
* Considered the definitive reference in the field
* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others

Editorial Reviews

Review

"It is comprehensive and up to date...the whole project represents a remarkable effort, coping as it does with an explosion of knowledge in this area. ...there are quite a number of reviews of this field, or parts of it, but relatively few text books, and certainly none as comprehensive as this. ...This is a timely book and truly reflects the enormous effort that is being put into tissue engineering at the present time. Highly recommended."
--E.J. Wood in RETINOIDS (2001)

From the Back Cover

The first edition of Principles of Tissue Engineering, published in 1997, was rapidly recognized as the definitive reference in the field. Since that time, the discipline has grown tremendously, and few experts could have predicted the explosion in the knowledge of gene expression, cell growth and differentiation, the variety of stem cells and new polymers, or even the successful introduction of the first tissue-engineered products into the marketplace. Principles of Tissue Engineering, Second Edition defines and captures the evolution of this fascinating and exciting field. This comprehensive reference covers the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, and the applications of tissue engineering to diseases affecting organ systems.
Key Features
* Essential to anyone working in the field
* Vast, detailed analysis of research with all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves
* Contributions by leaders in the latest areas of research, such as fetal tissue engineering and stem cells

See all Editorial Reviews

Product Details

• Hardcover: 995 pages
• Publisher: Academic Press; 2 edition (May 18, 2000)
• Language: English
• ISBN-10: 0124366309
• ISBN-13: 978-0124366305
• Product Dimensions: 11.1 x 8.6 x 1.8 inches
• Shipping Weight: 5.9 pounds
• Average Customer Review: 3.8 out of 5 stars  See all reviews (5 customer reviews)
• Amazon Best Sellers Rank: #1,406,384 in Books (See Top 100 in Books)

More About the Author

Dr. Robert Lanza is Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor at Wake Forest University School of Medicine. He has hundreds of publications and inventions, and over two dozen scientific books: among them, "Principles of Tissue Engineering," which is recognized as the definitive reference in the field. Others include One World: The Health & Survival of the Human Species in the 21st Century (Foreword by former President Jimmy Carter), and the "Handbook of Stem Cells" and "Essentials of Stem Cell Biology," which are considered the definitive references in stem cell research.

Dr. Lanza received his BA and MD degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He was also a Fulbright Scholar, and was part of the team that cloned the world's first human embryo for the purpose of generating embryonic stem cells. Dr. Lanza's work has been crucial to our understanding nuclear transfer and stem cell biology. In 2001 he was also the first to clone an endangered species (a Gaur), and in 2003, he cloned an endangered wild ox (a Banteng) from the frozen skin cells of an animal that had died at the San Diego Zoo nearly a quarter-of-a-century earlier. Lanza and his colleagues were also the first to demonstrate that nuclear transplantation could be used to reverse the aging process and to generate immune-compatible tissues, including the first organ tissue-engineered from cloned cells. One of his greatest early achievements came from his demonstration that techniques used in preimplantation genetic diagnosis could be used to generate human embryonic stem (hES) cells without embryonic destruction.

Lanza and colleagues have also succeeded in differentiating human pluripotent stem cells into retinal (RPE) cells, and has shown that they provide long-term benefit in animal models of vision loss. Using this technology some forms of blindness may be curable, including macular degeneration and Stargardt disease, a currently untreatable form eye disease that causes blindness in teenagers and young adults. Lanza's company (ACT) received FDA approval to begin clinical trials using them to treat degenerative eye diseases. These two clinical trials began in July 2011. Recently, ACT received similar approval for the first human embryonic stem cell trial in Europe.

Lanza has been a major player in the scientific revolution that has led to the documentation that nuclear transfer/ transcription factors can restore developmental potential in a differentiated cell. One of his recent successes was showing that it is feasible to generate functional oxygen-carrying red blood cells from human embryonic stem cells. The blood cells were comparable to normal transfusable blood and could serve as a potentially inexhaustible source of "universal" blood. His team also discovered how to generate functional hemangioblasts - a population of "ambulance" cells- from hES cells. In animals, these cells quickly repaired vascular damage, cutting the death rate after a heart attack in half and restoring the blood flow to ischemic limbs that might otherwise have to be amputated. Recently, Lanza and a team lead by Kwang-Soo Kim at Harvard University reported a safe method for generating induced pluripotent stem (iPS) cells. Human iPS cells were created from skin cells by direct delivery of proteins, thus eliminating the harmful risks associated with genetic manipulation. This new method provides a potentially safe source of patient-specific stem cells for translation into the clinic. The Editors of the prestigious journal Nature selected Lanza and Kim's paper on protein reprogramming as one of five "Research Highlights" of 2009. Discover magazine stated, "Lanza's single-minded quest to usher in this new age has paid dividends in scientific insights and groundbreaking discoveries."

Dr. Lanza has received numerous awards, including an NIH Director's Award (2010) for "Translating Basic Science Discoveries into New and Better Treatments"; the 2010 'Movers and Shakers' Who Will Shape Biotech Over the Next 20 Years (BioWorld)(along with Craig Venter and President Barack Obama); the 2007 100 Most Inspiring People in the Life-Sciences Industry (PharmaVOICE, "For his discoveries 'behind the medicines making a significant impact on the pipelines of today and of the future'"; the 2007 Outstanding Contribution in Contemporary Biology Award (Brown University, "For his groundbreaking research and contributions in stem cell science and biology"; the 2006 All-Star Award for Biotechnology (MA High Tech, for "pushing stem cells' future"); the 2005 Rave Award for Medicine (Wired magazine, "For eye-opening work on embryonic stem cells"); and Lanza is listed in Who's Who in America, Who's Who in the World, Who's Who in Medicine and Healthcare, Who's Who in Science and Engineering; Who's Who in American Education, and Who's Who in Technology, among others. Dr. Lanza has served in numerous national and international leadership capacities, including Conference Co-Chairman, International Symposium on Stem Cells (Tianjin, China 2008); Stem Cell Advisory Committee, International Stem Cell Registry; He has given keynote addresses at dozens of national and international societies, including ASAIO (2001), Annual Molecular & Cellular Biology Symposium (2002), Biotechniques Live/Drug Discovery Technology & Development World Congress (2005), International Stem Cell Conference (2007), Tissue Engineering & Regenerative Medicine International Society (TERMIS)(2007), Translational Regenerative Medicine Forum (2010), among others.

Dr. Lanza and his research have been featured in almost every media outlet in the world, including CNN, TIME, Newsweek, People, as well as the front pages of the New York Times, Wall Street Journal, Washington Post, among others. Lanza has worked with some of the greatest thinkers of our time, including Nobel laureates Gerald Edelman and Rodney Porter, renowned Harvard psychologist B.F. Skinner (the "Father of modern behaviorism"), Jonas Salk (discoverer of the Polio vaccine), and heart transplant pioneer Christiaan Barnard. His current research and work at Advanced Cell Technology focuses on stem cells and regenerative medicine and their potential to provide therapies for some of the world's most deadly and debilitating conditions.

In 2007, Lanza published a feature article, "A New Theory of the Universe" in The American Scholar, a leading intellectual journal which has previously published works by Albert Einstein, Margaret Mead, and Carl Sagan, among others. His theory places biology above the other sciences in an attempt to solve one of nature's biggest puzzles, the theory of everything that other disciplines have been pursuing for the last century. This new view has become known as Biocentrism. In 2009, he co-authored a book "Biocentrism: How Life and Consciousness are the Keys to Understanding the True Nature of the Universe" with leading astronomer Bob Berman. In biocentrism, space and time are forms of animal sense perception, rather than external physical objects. Understanding this more fully yields answers to several major puzzles of mainstream science, and offers a new way of understanding everything from the microworld (for instance, the reason for Heisenberg's uncertainty principle and the double-slit experiment) to the forces, constants, and laws that shape the universe. Nobel laureate E. Donnall Thomas stated "Any short statement does not do justice to such a scholarly work. The work is a scholarly consideration of science and philosophy that brings biology into the central role in unifying the whole."

You can read more about Dr. Robert Lanza's work at:

http://www.robertlanza.com/
http://www.robertlanzabiocentrism.com/
http://www.advancedcell.com/company/leadership-team/senior-executive-officers/

Customer Reviews

Most Helpful Customer Reviews

3 of 3 people found the following review helpful:

5.0 out of 5 stars Excellent reference, November 12, 2000

By A Customer

This review is from: Principles of Tissue Engineering, Second Edition (Hardcover)

A few too many equations, but clearly the most comprehensive text in the field. Contributors list reads like a 'Who's Who' of tissue engineering.

2 of 3 people found the following review helpful:

5.0 out of 5 stars Excellent textbook for students and researchers, December 2, 2000

By A Customer

This review is from: Principles of Tissue Engineering, Second Edition (Hardcover)

A vast, detailed summary of the latest advances in tissue engineering.

4 of 4 people found the following review helpful:

4.0 out of 5 stars Covering the whole body, September 28, 2001

By 

Peter Bernstein (Tübingen, Germany) - See all my reviews

This review is from: Principles of Tissue Engineering, Second Edition (Hardcover)

This is a great book, covering most details of its field. It describes the physicians (and their patients) dream of substituting organs and cells and it also shows, how mankind could not solve problems  up to now. History of artificial organs lacking the full function is one point, but the focus is on cells and their ability to build complete organs  and therefore the book looks on the pathway for the future of organ substitution.
The introduction covers some main ideas of tissue engineering  what do we want  what are we able to do  what do we still have to get knowledge of. After a short review of the history, the essentials of cell biology (Growth, Differentiation) are being introduced. The reader should have an idea of developmental biology to be able to follow topics like induction and morphogenesis. The authors emphasize the importance of the extracellular matrix as one of organ-prosthesis main building blocks (ECM = scaffold; cells = function; cell signalling = integration and physiology).
The second part describes technical aspects of in-vitro organ synthesis: tissue culture and ECM, tissue culture und growth factors, bioreactors and vascularization. The third part continues with in-vivo techniques of organ reparation, exemplified by methods for substitution of the ECM of skin, peripheral nerves and meniscus.
Parts 4  6 develop models for the substitution of the ECM (Collagen, BioPolymers), their implantation in the receiving organism and the resulting immunologic problems (emphasized).
Parts 7  20 are concerned with the organs themselves. After few words about stem cells and gene therapy the book explains reconstruction and substitution methods for breast, heart and blood vessels, Cornea, endocrine glands, liver (very good), kidney and haematopoietic system. Biomechanical problems are outlined in the part about the musculoskeletal system. On this place tissue engineering celebrates its oldest success (cartilage substitution). Today innervation processes are being focused.
The book continues with substitutes for the senses (ear and eye), nerve cells, nerve regeneration and neural stem cells. Dents and skin could be all to make an ill patient healthy by substitutes, one might think. But no, western medicine also knows something about substitutes for womb and placenta
On me the book made a good impression. The only point is: its quite too much text and too few pictures. It addresses medicals after their exams, practicing physicians and biologists. Chapters focus on the basic principles. There is a large number of links to more detailed publications.