Principles of Translational Science in Medicine: From Bench to Bedside [Hardcover]

Martin Wehling (Editor), Francesco M. Marincola (Foreword)

Book Description

Publication Date: December 21, 2009 | ISBN-10: 0521888697 | ISBN-13: 978-0521888691 | Edition: 1

Despite advancements in the cloning of the total human genome, biomedical innovations at the patient level are becoming rare events. However, translational medicine is a burgeoning science that shows the potential to reverse the trend. This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations, including target risk assessment, biomarker evaluation, and predictivity grading for both efficacy and toxicity; early human trial designs that are adequate to guide stop or go decisions on the grounds of biomarker panels; and biostatistical methods to analyze multiple readout situations and quantify risk projections. The book provides guidance to design smart profiling strategies for new approaches aimed at cutting timelines and concentrating on the comparison of quality issues of early developmental processes for pharmaceutical and biotechnology research. By furthering the substantiation of translational medicine, creating awareness about its potential to promote innovations into clinical practice, and examining the terminology surrounding current biotechnologies, this book hopes to create a dialogue about translational science and what this will mean for patient care in the near future.

Editorial Reviews

Book Description

This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations and guides readers in designing smart profiling strategies for new approaches to the field.

About the Author

Professor Mark Wehling is an internist, cardiologist, and full professor of clinical pharmacology at the University of Heidelberg, Germany. He has authored more than 200 scientific publications and several books and has been recipient of the Heisenberg Scholarship from Deutsche Forschungsgemeinschaft. After working as Director of Discovery Medicine at AstraZeneca, he returned to his academic position in 2007. In his return to academia, his aim is to further translational medicine by aligning academic and private activities to support biomedical innovation. His main tools are connecting distant players in the translational process; bridging gaps between preclinical and clinical stages; assembling, developing, and profiling biomarkers with particular assessment of their predictive value; and developing smart translational plans to reliably and swiftly promote translatable projects.

Product Details

• Hardcover: 404 pages
• Publisher: Cambridge University Press; 1 edition (December 21, 2009)
• Language: English
• ISBN-10: 0521888697
• ISBN-13: 978-0521888691
• Product Dimensions: 10.1 x 7 x 1 inches
• Shipping Weight: 2.3 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #425,155 in Books (See Top 100 in Books)