Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. This concise and readable text uses real examples and case histories from ICI/Zeneca Pharmaceuticals to show the problems which may be encountered in scaling up chemical synthesis, and the ways these problems may be overcome. It shows how it is possible to synthesize multi-kilogram quantities of a new organic compound which has been made in the laboratory only in the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. This book will be invaluable both to the research chemist involved in the development phase of novel compounds, and the advanced undergraduate interested in the fine chemicals industry.
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`excellent..volume' Chemistry in Britain
About the Author
Stan Lee and Graham Robinson are both at Zeneca Pharmaceuticals, Macclesfield, Cheshire.
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4.0 out of 5 stars
Nice chemistry book,
Amazon Verified Purchase(What's this?)
This review is from: Process Development: Fine Chemicals from Grams to Kilograms (Oxford Chemistry Primers) (Paperback)
Great book in industrial organic chemistry. It presents cases on how several problems were solved when going "from the flask to the tank" (wow, that's a beatiful phrase).
-Organic chemists will be pleased it has no numbers or equations, just reaction steps, yields and plain text. -Industrial chemists will find themselves amused by the rational and systematic approach taken with each case and the diversity of problems expalined. -Chemical engineers will be frustrated for the lack of information on the final industrial processes.
5.0 out of 5 stars
Real examples,
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This review is from: Process Development: Fine Chemicals from Grams to Kilograms (Oxford Chemistry Primers) (Paperback)
Process development is generally not taught in schools. However it is the everyday practice of many industrial chemists. The book is really helpful in bridging these two quite different aspects of organic synthesis. It describes the issues, problems, and solutions in scale-up. It also covers environmental and regulatory issues and more importantly, commonly and preferrably used solvents and reagents in large scale operations. Real examples from pharmaceuticals are used to demonstrate all these issues and the way to synthesize fine chemicals in multi-kilogram quantities instead of laboratory milligram scale.
An excellent small book, easy and fun to read. Recommended to both the experienced and beginners.
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Inside This Book
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First Sentence:
This book is intended as a general introduction to fine chemicals manufacture and a guide to the principles and practice of process development. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
dioxan ring, homochiral auxiliary, top side chain, research route, trimethylsilyl iodide, relative stereochemistry, manufacturing route, aldol reaction, vinyl bromide, butyl lithium, absolute stereochemistry, plant scale, reaction solvent New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
This book is intended as a general introduction to fine chemicals manufacture and a guide to the principles and practice of process development. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
dioxan ring, homochiral auxiliary, top side chain, research route, trimethylsilyl iodide, relative stereochemistry, manufacturing route, aldol reaction, vinyl bromide, butyl lithium, absolute stereochemistry, plant scale, reaction solvent New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
3
books
cite this book:
- Drugs-From Discovery to Approval by Rick Ng on page 263, and page 279
- Practical Process Research & Development by Neal G. Anderson on page 28
- Job$ in the Drug Indu$try: A Career Guide for Chemists by Richard J. Friary on page 211
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