THIS VACCINE CANNOT BE SHIPPED TO MINNESOTA. A modified live virus vaccine used to vaccinate healthy dogs against distemper (Onderstepoort strain), hepatitis caused by CAV-1 and tracheobronchitis caused by CAV-2 (CAV-2 Manhattan strain cross-protects), parainfulenza and parvovirus infection (strain 154). Directions: 1 ml dose intramuscularly or subcutaneously at 6 weeks of age. Repeat every 3 to 4 weeks until 12 to 16 weeks of age. Dogs over 12 weeks of age should be vaccinated twice 3 to 4 weeks apart. Do not freeze. Avoid vaccinating pregnant bitches. An annual booster is recommended.