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Aspartic Acid Proteases as Therapeutic Targets, Volume 45 (Methods and Principles in Medicinal Chemistry) Hardcover – October 4, 2010

ISBN-13: 978-3527318117 ISBN-10: 3527318119 Edition: 1st

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Editorial Reviews


"Overall, this book comprises an excellent themes and publications based on aspartic protease research, and I strongly recommend this book for novices, as well as experienced researchers in this area." (ChemMedChem, 2011)


From the Back Cover

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to sechs present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in academics and pharmaceutical industry, as well as for anyone studying proteases and their function.

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