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Proteomic and Genomic Analysis of Cardiovascular Disease [Hardcover]

Jennifer E. Van Eyk (Editor), Michael J. Dunn (Editor)

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Book Description

May 15, 2003 3527305963 978-3527305964 1
This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease—the number-one killer in the industrialized world.

Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.


Editorial Reviews

Review

"This is a delightful book with something to offer both novice and experts in the field.” (Modern Pathology, October 2004)

"In summary, this book provides a strong foundation in genomic and proteomic methodology and will bring the reader to the forefront in the use of these tools in cardiovascular disease research.” (Clinical Chemistry, 50, No. 7, 2004)

"...provides a timely integration of the emerging technologies of genomics, proteomics and drug discovery...suitable for all levels..." (Briefings in Functional Genomics and Proteomics, Vol 2(4), Feb 2004)

"This is a very good book, whose best virtue is that it reliably reflects the current status of genomics and proteomics in the cardiovascular area. The inclusion of both fields in the same book could be considered excessively ambitious, but the result is very positive.... Overall, this is a highly recommended book, written by specialists in their fields, offering a clear and concise overview of the basis for, and latest developments in, cardiovascular genomics and proteomics." (Human Genomics, January 2004)

From the Back Cover

This is the first book to provide a comprehensive and unique overview of proteomic and genomic analysis with a specific focus on cardiovascular disease. In its entirety, this book gives tantalizing glimpses into the incredibly dynamic and complex working of a cell and the cardiovascular system as it adapts to stress, its environment, and disease. These new scientific disciplines, proteomics and genomics, collectively give a rare and global perspective on biology.

21 contributions written by renowned experts in the field.

  • Highlight a variety of proteomic and geomic strategies, their essential technologies along side a glimpse into future technological platforms.
  • Address important current issues, limitations and promise, in the application of proteomics and genomics, specifically with respect to disease.
  • Provide new and exciting insights into the biochemical and cellular mechanisms underlying a range of cardiovascular diseases.
  • Describe translational science in which proteomic-and genomic-derived information is used for clinical discovery and validation of novel biomarkers and therapeutic targets of disease.

An excellent book for graduate students, post-doctoral and clinical fellows along with researchers in academia and industry to read and learn about the latest developments in cardiovascular proteomics and genomics.


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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
cardioprotective genes, myofilament proteins, affinity pull, quantitative proteome analysis, differential protein expression, multidimensional protein identification technology, electrophoresis database, biological annotation, protein expression changes, myocardial gene expression, proteomic platform, cardiac gene expression, cyclic stretch, difference gel electrophoresis, myocardial proteins, protein spots, biomarker discovery, protein expression analysis, tandem affinity purification, proteomic analysis, protein abundance, low abundance proteins, proteomic strategies, antibody arrays, cardiac proteins
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Natl Acad, Sypro Ruby, Nature Biotechnology, United States, Analytical Chemistry, Circ Res, Mass Spectrom, Nature Genetics, Nucleic Acids Res, Cell State, Smooth Muscle Cell Physiology, Amersham Biosciences, Circulation Research, New York, Analytical Biochemistry, Cell Cardiol, Applied Biosystems, Biol Chem, Clin Invest, Current Opinion, Journal of Molecular Biology, Nat Biotechnol, Anal Biochem, Basic Res, Blood Institute
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