In the mid 2000's, Dr. Helen Jara carried out a series of psychological experiments on a group of patients with schizophrenia. These experiments were not approved by the board of Psychological Studies. Dr. Jara was attempting to prove that these patients' hallucinations were of paranormal origin. She succeeded by recording unexplained paranormal phenomena on a series of devices; but in the process of doing so, the paranormal activity increased dramatically, culminating in the unexplained death of Dr. Jara, Parapsychologist Matias Kram and his assistant. When the videotapes and recordings were found by investigators, they discover bone chilling EVPs that were not documented in the journals, resulting in the unexpected manifestation of horrifying Psychophonies. The youngest patient is asked to return and resume the experiment, which results in a confrontation with dark and nefarious forces from the other world.