Here is a clear, well organized, and expertly detailed review of the current knowledge regarding the genesis and clearance of lung fluid at rest and during exercise, in neonates and adults. This book explains, at both the molecular and cellular level, the mechanisms underlying the pathophysiology of varying pulmonary oedemas. Based on this understanding, new treatment approaches are explored. Beginning with comparative physiology and a variety of animal models including the newborn, the authors go on to discuss:
- liquid flow within the lung and its reabsorption from the alveoli
- the activity within microvascular endothelial cells
- hydrostatic pressure effects
- the problem of increased leakiness of the alveolar-capillary barrier
- possible interactions with particular barrier molecules
