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Pulmonary Pathophysiology: The Essentials Paperback – June 12, 2007

ISBN-13: 978-0781764148 ISBN-10: 0781764149 Edition: Seventh

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Product Details

  • Series: Pulmonary Pathophysiology
  • Paperback: 224 pages
  • Publisher: Lippincott Williams & Wilkins; Seventh edition (June 12, 2007)
  • Language: English
  • ISBN-10: 0781764149
  • ISBN-13: 978-0781764148
  • Product Dimensions: 9 x 6.5 x 0.2 inches
  • Shipping Weight: 1 pounds
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (9 customer reviews)
  • Amazon Best Sellers Rank: #319,098 in Books (See Top 100 in Books)

More About the Author

UCSD School of Medicine Logo
photo of John B. West
John B. West, M.D., Ph.D., D.Sc.
Distinguished Professor of Medicine and Physiology
School of Medicine
University of California, San Diego
San Diego, CA 92093-0623A
Tel: (858) 534-4192
FAX: (858) 534-4812
E-mail: jwest@ucsd.edu

* Formal Curriculm Vitae
* Brief Narrative CV
* Publications:
o Books
o Articles

John West was born in Adelaide, Australia in 1928. He had the good fortune to attend an excellent high school and developed a love of science, particularly high energy physics. He considered this for a career but as was the custom then (and still is) he moved straight from high school to one of the faculties of the University of Adelaide and, for various reasons, chose medicine. He graduated with a medical degree in 1951 after the six years' course at the age of 23. After a year of residency he moved to London, partly because academic medicine was not well developed in Adelaide at the time, but also because he wanted to see the world.

He spent about 15 years in London, mainly at the Royal Postgraduate Medical School, Hammersmith Hospital, initially with Drs. Philip Hugh-Jones and Charles Fletcher. A remarkably serendipitous event occurred in 1956 when the Medical Research Council cyclotron started to produce radioactive oxygen-15. By inhaling this and looking at its disappearance from the lung, it became clear that there was a dramatic topographical inequality of blood flow caused by gravity. The mechanism of this was worked out, and this led to other studies on the effects of gravity on the lung including regional differences of ventilation, gas exchange, and alveolar size.

In 1960 he learned that Sir Edmund Hillary was planning a physiological expedition to the Himalayas, and he applied and was accepted in spite of the fact that he had never previously done any climbing. This was the so-called Silver Hut expedition where a small group of physiologists wintered at an altitude of 5800 m (19,000 ft) just south of Everest and carried out an extensive physiological program. Subsequently measurements were extended up to an altitude of 7440 m (24,400 ft) on Mt. Makalu. This began a long interest in high-altitude medicine and physiology and culminated in him leading the 1981 American Medical Research Expedition to Everest during which 5 people reached the summit, and the first physiological measurements on the summit were made. The basic scientific question addressed in these studies is how is it possible for humans to survive in the extreme oxygen deprivation of these great altitudes which are right at the limit of human tolerance. His interest in this field continues to this day with a project on oxygen enrichment of room air at high altitude which promises to be critically important for commuters who need to work at very high altitudes. He also edits a new journal, High Altitude Medicine & Biology.

Because of his interest in the effects of gravity on the lung, he thought it would be valuable to study the lung in weightlessness, and took a period of sabbatical leave at the NASA Ames Research Center in 1967-1968. During this time he submitted a proposal to NASA to study pulmonary function in astronauts. This was funded the following year and he enjoyed continuous financial support from NASA until 2006. Experiments were conducted on four Spacelabs in orbit, and on the International Space Station. Of all the organs in the body, the lung is arguably the most vulnerable to gravity, and the basic question here is how is lung function altered by exposure to weightlessness in both the short and long terms. A monograph on pulmonary function in space has recently been published by his group.

Dr. West joined the faculty of the University of California San Diego in the spring of 1969 and has been there ever since. His research has ranged over a wide field including an extensive study of ventilation-perfusion inequality in the lung. He continues an interest in the pulmonary circulation and particularly the dilemma of the blood-gas barrier which has to be both extremely thin and immensely strong. When the pressure in the pulmonary capillaries becomes high, or the lung is inflated to large volumes, stress failure of the walls of the capillaries occurs, and this phenomenon is important in a variety of lung diseases. He is addressing the basic biological question of how the blood-gas barrier of the lung is regulated so that it is sufficiently thin for efficient gas exchange yet strong enough to avoid stress failure.

Dr. West is a dedicated teacher. He was in charge of the physiology course for first year medical students at UCSD for 35 years and his little red book Respiratory Physiology: The Essentials has been translated into 13 languages and is used all over the world. He also has a strong interest in the history of medicine and has written several books on the subject. His monograph High Life is a standard history of high altitude physiology and medicine. He has developed an archival collection of material in high-altitude medicine and physiology for the special archival library at the University of California, San Diego.

Dr. West has had many honors including president of the American Physiological Society, foreign member of the Russian Academy of Sciences, founding fellow of the American Institute for Medical and Biological Engineering, honorary doctorates from the universities of Barcelona, Ferrara and Athens, fellow of the American Academy of Arts and Sciences, and member of the Institute of Medicine of the National Academy of Sciences.
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Last updated September 12, 2008.
©2008 John B. West. All rights reserved.

Customer Reviews

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Most Helpful Customer Reviews

15 of 17 people found the following review helpful By G. Warwick on May 6, 2008
Format: Paperback
Like Chairman Mao, Dr John West has terrorized legions of young men and women with his little red book. His original textbook of respiratory physiology has become a classic of its time, being the first (and often last) foray into really difficult physiology equations that many a med student or resident dares to take. For many, it has no doubt been the last straw that drove them into a career in orthopedic surgery. This follow-up offering, with its mixture of science and padding, is easier to follow but, ultimately, less useful. Following on from the foundation of the red book, this one aims to present the science in a more clinical context. However, the reader is left with a sense that, in some chapters, he was struggling to come up with enough good physiology to fill the pages, and instead he delivers whole sections without an equation or scientific principle to be seen. This can be seen either as vice or virtue, since it reads a lot more easily and can give basic insights into conditions without tripping the reader up with arcane equations. But it can fail to deliver quite the same intense burst of brain food that the red book provided. It should be seen more as an introduction to pathophysiology than a useful text, but is a good way to look like you're reading something clever without overly straining the grey matter. Despite all this, I would recommend it as an amuse-bouche before the main course of a three-course respiratory phsiology text book.
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19 of 22 people found the following review helpful By Sean Young on June 13, 2000
Format: Paperback
This book is very concise and covers all of the necessary information for a Pulmonary Disease course. Also worthy of mention is the fact that is is the top selling book in the field in it's category. I find it perfect for a Respiratory Therapist, Medical Student, or Physician's Assistant due to the easy to learn format and clear writing style of the author. Also, rumor has it that West is coming out with a combined Pathophysiology and Physiology for Pulmonary that should be well done as well.
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7 of 9 people found the following review helpful By dr patrick c. jacques on March 2, 2006
Format: Paperback
In his books Dr West does a great job teaching basic Respiratory Physiology and Respiratory Physiopathology.The easy-to-read texts will be very helpfull to medical studends in their first years and for USLME review.
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1 of 1 people found the following review helpful By LongRodSilver on March 18, 2011
Format: Paperback Verified Purchase
The book is pretty good for the heavy hitters in pulmonary, but does skip on some of the rarer diseases we we're tested on, but overall a good read and reinforcement of lectures.
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By Elizabeth M. Nieves on November 29, 2011
Format: Paperback
Very good book, but only if it's being supplemented with a class. I feel as though to fully understand the material on its own with simply reading the book would be a monumental task. Though in fairness, the respiratory system has always been my weakest point in physiology. The figures and diagrams were VERY useful.
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