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Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research Hardcover – November 7, 2008

ISBN-13: 978-0080466170 ISBN-10: 0080466176 Edition: 1st

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Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research + Drug-like Properties:  Concepts, Structure Design and Methods: from ADME to Toxicity Optimization + The Organic Chemistry of Drug Design and Drug Action, Second Edition
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Product Details

  • Hardcover: 600 pages
  • Publisher: Elsevier Science; 1 edition (November 7, 2008)
  • Language: English
  • ISBN-10: 0080466176
  • ISBN-13: 978-0080466170
  • Product Dimensions: 1.1 x 7.5 x 9.6 inches
  • Shipping Weight: 2.9 pounds (View shipping rates and policies)
  • Average Customer Review: 4.9 out of 5 stars  See all reviews (22 customer reviews)
  • Amazon Best Sellers Rank: #1,088,011 in Books (See Top 100 in Books)

Editorial Reviews

Review

BRITISH TOXICOLOGY SOCIETY NEWSLETTER, Summer 2010 issue: "[I]lluminating and stimulating, as the author uses examples to demonstrate how the challenge of making new, profitable, drugs has changed in the last few years, as well as the shape of pharmaceutical companies themselves.. The relaxed writing-style of the author makes this book both very easy to read and enjoyable, while at the same time peppering the reader with new facts. Whereas the book is labeled as a chemist's guide, I suspect that it would be of use to many people entering the drug discovery arena, be they chemists or not. Robert Rydzewski has succeeded in producing a text that will find its way onto the shelves of many early career-stage scientists, and I think they will be considerably improved by reading it." - Nick Plant, Centre for Toxicology, University of Surrey, UK

JOURNAL OF MEDICINAL CHEMISTRY, Volume 53, number 4: As explained in his preface, the purposes of [the author's] treatise are to present new researchers "with a basic overview of how modern industrial drug discovery works", to introduce the relevant scientific disciplines, and "to provide some practical insights into common problems in drug discovery", and possible solutions. In my opinion, he has achieved these goals in an excellent manner. .This book is enthusiastically recommended to graduate faculty and students, to postdocs, recent graduates, young workers in the pharma industry, to anyone who would like a one-volume review of modern industrial drug discovery, and to the libraries that serve these groups. - Manfred E. Wolff, Intellepharm, Inc.

CHOICE, April 2009: "More than a primer, this book serves as an excellent introduction to research in industry in general and the pharmaceutical industry in particular, as well as a career resource ... Of particular interest to chemistry graduate students as well as research-orientated undergraduates and their mentors. Summing Up: Highly recommended." - R. E Buntrock, formerly, University of Maine

About the Author

Over 24 years experience in industry including positions at: Celera Genomics, Gensia Pharmaceuticals, Syntex Corporation, Shell Development and G.D. Searle and Company.

Author of 21 papers, 12 patent applications and 2 book chapters.

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Customer Reviews

4.9 out of 5 stars
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Overall, this is a very good and very well written book.
J. Avellanet
This book is a tome on the chemist's journey into the biotech and pharmaceutical research world.
Peggy
At times I was lost and had to re-read portions of the book.
Kersi Von Zerububbel

Most Helpful Customer Reviews

10 of 10 people found the following review helpful By Tom Brody VINE VOICE on July 20, 2009
Format: Hardcover Vine Customer Review of Free Product ( What's this? )
REAL WORLD DRUG DISCOVERY by Robert Rydzewski is a glitzy 515 page book, on glossy paper, with hundreds of figures and graphs, many in color, disclosing structures of organic chemicals, time courses of metabolism, enzyme kinetics, and economics. Where the discussion concerns a specific organic chemical, e.g., used as a drug, we find a picture of it on the same page. In this way, the author is an excellent communicator. The book is attractive because the writing is slightly informal, and yet the book is highly factual and reliable.

At first, we are provided with a short history of organic chemistry, biotechnology, and genomics (pages 1-13). We then learn about pharmaceutical economics (pages 13-47). We learn the cost of bringing a new drug to market, and that this particular number has been calculated to be one of a number of million dollars, depending on how it is calculated (page 14). We learn of the Hatch-Waxman Act, and how it has encouraged generic manufacturers to unfairly challenge patents held by pharma companies (page 22). We learn about pitfalls facing pharma, namely, market withdrawals, adverse events, blackbox warnings, and competition from generics. We also learn how pharma reduces competition from generics, by creating your own generic, negotiating with insurance companies, and providing over-the-counter status (page 24). We learn various reasons why biologicals don't go generic.

CONTRACT RESEARCH ORGANIZATIONS (CROs). We learn about CROs, which let a startup hit the ground running (without having to buy lab equipment or to hire personnel), but that the disadvantage of CROs is often that they may be just a pair of hands (page 76-79).

PERSONALIZED MEDICINE.
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6 of 6 people found the following review helpful By A. Jogalekar TOP 1000 REVIEWERVINE VOICE on August 13, 2009
Format: Hardcover Vine Customer Review of Free Product ( What's this? )
Drug discovery and development is a complex, highly multidisciplinary endeavor in which practitioners have to have knowledge about a disparate range of topics, from chemistry and biology to outsourcing, patent laws and business aspects. It is not physically possible for any one person to have detailed knowledge about all these areas. What is therefore necessary is a book that provides bite-sized chunks about the most relevant aspects of the science, art and commerce of drug discovery and development that will keep scientists, technologists, lawyers and businessmen up to date with the essentials.

Rydzewski's Real World Drug Discovery admirably fills this void. In clear, comprehensive and sometimes witty prose he describes the most essential aspects of the field. He begins with the basics of drug development, including a history of the industry and the challenges that it had to face along the way. Then, in a series of chapters the author leads the reader through a remarkable range of topics. A sampling of examples makes the impressive diversity of scientific, business and legal topics clear; patent law, Hatch-Waxman and Bayh-Dole acts, generics, outsourcing and patent busting, high-throughput screening, stereochemical aspects, mouse knockouts and RNA interference, process research and manufacturing, gene arrays and pharmacogenomics, biotechnology, pharmacokinetics and metabolism, side-effects, structure-based drug design and computational modeling, FDA rules, mergers and acquisitions, project management and leadership and statistics and trends. And in spite of such broad coverage, Rydzewski pays a remarkable amount of attention to detail.
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6 of 6 people found the following review helpful By J. Avellanet VINE VOICE on July 28, 2009
Format: Hardcover Vine Customer Review of Free Product ( What's this? )
Overall, this is a very good and very well written book. Any aspiring chemist thinking of entering into the world of pharmaceutical and biotechnology R&D should get this book - it covers a lot of ground that will otherwise take 2-3 years to learn ... the hard way.

The first third of the book is focused on the big picture of the current landscape, from the evolving role of big pharma to the struggles of biotech companies.

The second third of the book covers more tactical aspects like project teams and how work in corporations is conducted under projects (for which the new chemist will likely be lucky to only be involved in one or two at once).

The last third of the book tackles specific chemistry issues associated with drug discovery. It should be noted that all of this is in the discovery or "fundamental" research stage (e.g., before clinical trials) - so there is no mention of regulatory compliance or quality systems needs.

Every so often, the author has put in small summary boxes of key topics to drive home his details - this is very helpful and something that I wish more authors would do, especially when writing about complex, interrelated topics.

The minor drawbacks that I found in this book that kept it from being 5 stars for me:

Throughout, there is significant emphasis on the increasingly successful role of academia in drug development, but zero discussion of some of the more recent innovations such as NRDO (no research, development only) companies. As a result, I walked away wondering if this book was a call to come help industry develop new drugs inside of industry or as a member of academia.

Also missing was a discussion of the various state efforts throughout the U.S.
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