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Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage Sensitive Ion Channels
 
 
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Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage Sensitive Ion Channels [Hardcover]

Stephen Moss (Editor), Jeremy Henley (Editor)

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Book Description

0192632248 978-0192632241 August 15, 2002 1
A volume in the Molecular and Cellular Neurobiology series.
This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states.
The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on accetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors.
Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.

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Editorial Reviews

Review

"The editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read." Nature Cell Biology

About the Author

Stephen Moss is at MRC-LMCB and Department of Pharmacology, University College London, UK. Jeremy Henley is at MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, UK.

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Inside This Book (learn more)
First Sentence:
Mammalian voltage-gated sodium channels (VGSCs) comprise a single family of 10 related functional subunits that appear to have arisen by gene duplication (Catterall 2000). Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
channel biogenesis, agrin treatment, acetylcholine receptor aggregation, acetylcholine receptor clustering, postsynaptic targeting, protein gephyrin, extrasynaptic receptors, carbonic anhydrase domain, channel trafficking, acetylcholine receptor clusters, receptor anchoring, chick optic lobe, receptor surface expression, chick ciliary ganglia, agrin receptor, chick ciliary ganglion neurons, postsynaptic clustering, class kinases, heterologous expression studies, inhibitory glycine receptor, cultured muscle cells, cytoskeletal anchoring, sulphonylurea receptor, chimeric subunits, synapse maturation
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cell Biol, Brain Res, Nature Neurosci, Trends Neurosci, Aguilar Bryan, Springer Verlag, Cell Sci, Nature Genet, New York, Receptors Channels, Trends Pharmacol, Genes Cells, Pflugers Arch
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