Amazon.com: Reconceiving the Gene: Seymour Benzer's Adventures in Phage Genetics (9780300110784): Professor Frederic Lawrence Holmes, Dr. William C. Summers M.D.: Books
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Reconceiving the Gene: Seymour Benzer's Adventures in Phage Genetics
 
 
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Reconceiving the Gene: Seymour Benzer's Adventures in Phage Genetics [Hardcover]

Professor Frederic Lawrence Holmes (Author), Dr. William C. Summers M.D. (Editor)

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Hardcover, June 21, 2006 $60.00  

Book Description

June 21, 2006 0300110782 978-0300110784 1
This book relates how, between 1954 and 1961, the biologist Seymour Benzer mapped the fine structure of the rII region of the genome of the bacterial virus known as phage T4. Benzer’s accomplishments are widely recognized as a tipping point in mid-twentieth-century molecular biology when the nature of the gene was recast in molecular terms. More often than any other individual, he is considered to have led geneticists from the classical gene into the molecular age.
 
Drawing on Benzer’s remarkably complete record of his experiments, his correspondence, and published sources, this book reconstructs how the former physicist initiated his work in phage biology and achieved his landmark investigation. The account of Benzer’s creativity as a researcher is a fascinating story that also reveals intriguing aspects common to the scientific enterprise.

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Editorial Reviews

Review

"Holmes, a master of the historical fine-mapping of science, uses Benzer's pathbreaking contributions to show how molecular biology and classical genetics converged in the mid-twentieth century."-Angela Creager, Princeton University (Angela Creager )

"Famous for his exploration of the investigative pathways by which scientists have arrived at major discoveries, the late Professor Holmes has here applied this approach to Benzer's study of the fine structure of the genetic map of a bacterial virus. Scholarly, authoritative and a revelation."-Robert Olby, University of Pittsburgh (Robert Olby )

About the Author

The late Frederic Lawrence Holmes was Avalon Professor and chair for the Section of History of Medicine at Yale University. William C. Summers is professor of therapeutic radiology and molecular biophysics and biochemistry, as well as lecturer in history, at Yale University. 
 

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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
phage biologists, mottled plaques, factorial hypothesis, phage workers, multiplicity reactivation, lysogenic bacteria, infective centers, phage research, phage course, percent recombination, phage biology, free phage, lysogenic strain, lysis inhibition, investigative pathway, enzymatic adaptation, phage group, phage growth, phage development, reversion rates, neighboring nucleotides, classical geneticists, phage genetics, stable mutants, intracellular development
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cold Spring Harbor, Oak Ridge, Institut Pasteur, Hermann Muller, Max Delbrück, Gunther Stent, New York, Elie Wollman, Jim Watson, Sydney Brenner, George Beadle, George Streisinger, Biology Division, Genetic Region, Pacific Grove, François Jacob, Milislav Demerec, Herman Kalckar, Rockefeller Foundation, Joe Bertani, André Lwoff, Brookhaven National Laboratory, Elof Carlson, Jacques Monod, Single Bacterial Cells
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Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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