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Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases (Wiley - Interscience Series on Mass Spectrometry) [Hardcover]

Isabella Dalle-Donne (Editor), Andrea Scaloni (Editor), D. Allan Butterfield (Editor), Dominic M. Desiderio (Series Editor), Nico M. Nibbering (Series Editor)

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Book Description

June 12, 2006 0471723452 978-0471723455 1
Methodology and applications of redox proteomics



The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.

Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including:
* The role of oxidized proteins in various disorders
* Pioneering studies on the development of redox proteomics
* Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications
* The response and regulation of protein oxidation in different cell types
* The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease


Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Editorial Reviews

Review

"...a major book...readers interested in mass spectrometry methods in proteomics will find much that is of interest here." (Journal of the American Society for Mass Spectrometry, March 2007)

"Every laboratory that uses redox proteomics in both clinical and academic research should possess a copy of this excellent book." (Doody's Health Services)

"…highly recommended as a reference text…Redox Proteomics is thought to be a milestone in this field…" (Biotechnology Journal, March 2007)

From the Back Cover

Methodology and applications of redox proteomics

The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.

Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including:

  • The role of oxidized proteins in various disorders
  • Pioneering studies on the development of redox proteomics
  • Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications
  • The response and regulation of protein oxidation in different cell types
  • The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease

Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.


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Inside This Book (learn more)
First Sentence:
Proteins are highly sensitive to oxidative modifications by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Read the first page
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Free Radic Biol Med, Proc Natl Acad Sci, Arch Biochem Biophys, Biochem Biophys Res Commun, Clin Invest, Circ Res, Biochim Biophys Acta, Brain Res, Anal Biochem, John Wiley, Andrea Scaloni, Chem Res Toxicol, Isabella Dalle-Donne, Kidney Int, Methods Enzymol, Free Radic Res, New York, Obstet Gynecol, Antioxid Redox Signal, Allan Butterfield Copyright, Biochem Pharmacol, Clin Chim Acta, Cell Cardiol, Cardiovasc Res
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