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Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves Hardcover – October 2, 2012

ISBN-13: 978-0465021758 ISBN-10: 0465021751 Edition: 1st

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Product Details

  • Hardcover: 304 pages
  • Publisher: Basic Books; 1 edition (October 2, 2012)
  • Language: English
  • ISBN-10: 0465021751
  • ISBN-13: 978-0465021758
  • Product Dimensions: 1.1 x 6.3 x 9.5 inches
  • Shipping Weight: 1.2 pounds (View shipping rates and policies)
  • Average Customer Review: 4.1 out of 5 stars  See all reviews (55 customer reviews)
  • Amazon Best Sellers Rank: #86,101 in Books (See Top 100 in Books)

Editorial Reviews

Review

Science News
“Reading the first book penned by Church, a Harvard biologist and polymath, is like falling down a rabbit hole straight into his fermenting brain. Church’s wide-ranging career includes developing novel methods for reading the genetic instruction manual, or genome, of creatures from bacteria to humans. Now he focuses on synthesizing those instructions from scratch.... [A] dizzying survey of how scientists have unearthed the secrets of living organisms and are now using that information to revamp life itself.”

Robert T. Gonzalez, io9
“[A] phenomenal read.”

Wall Street Journal
“A definitive account of the advances and business ventures that define this new science [of synthetic biology]…. When history is written centuries from now, it is more likely that writing DNA will be the most enduring innovation [of our age].”

New Scientist
“Bold and provocative… Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”

Nature
“The life sciences emerge as the new high-tech in this paean to synthetic biology…. Each step in the genome’s evolution serves as a springboard for expositions of how synthetic biology will revolutionize renewable energy, multivirus resistance, and more.”

Mike Loukides, O’Reilly Radar
“If there’s one book that can turn this movement into a full-blown revolution, this is it.”

Derek Jacoby, O’Reilly Radar
“George Church and Ed Regis pull off an exciting and speculative romp through the field of synthetic biology and where it could take us in the not too distant future…. Regenesis provides an accessible and engaging introduction to the revolutionary potentials of synthetic biology and should be of interest to both experts and a general science audience.”

The Scientist
“[A]n important and surprisingly accessible book, magisterially structured to intertwine the accelerated history of synthetic biology with its precedents in humanity’s earlier technological revolutions and in the epochal evolution of life itself. The book packs in a superb short course on life’s molecular workings, enabling the reader to grasp how we can actually contemplate resurrecting mammoths and Neanderthals, brewing biofuel from seawater and sunlight, engineering total immunity to viral infection, storing data in DNA, and more.”

Nathan Myhrvold, Founder and CEO, Intellectual Ventures
“A delightfully opinionated, visionary and controversial romp through synthetic biology, which is one of the most important technologies of our time."

Eric Topol, Professor of Genomics, The Scripps Research Institute, and author of The Creative Destruction of Medicine
“Literally reinventing nature could provide solutions to intractable problems with the energy supply, global warming, and human health. In Regenesis, George Church, a pioneer and pre-eminent force in promoting our ability to read DNA sequence, now guides us to the future: writing DNA sequence. Teaming up with Ed Regis, Church provides a mind-bending, tour de force account of how this seventh industrial revolution will take hold, and how ultimately the survival of our planet and the human species may rely upon rewriting the code of life. An enthralling journey into the future—with truly profound implications—that should not be missed.”

Stewart Brand, author of Whole Earth Discipline
“Here you will find the bleeding, screaming, thrilling edges of what is becoming possible with genomic engineering, handsomely framed in the fine-grained fundamentals of molecular biology. It is a combination primer and forecast of what is coming in this ‘century of biology’ from the perspective of a leading pioneer in the science.”

Kirkus Reviews
“[An] authoritative, sometimes awe-inspiring book…. A valuable glimpse of science at the edge.”

Publishers Weekly
“Exhilarating and scary facts suffuse this book about bioengineering by leading Harvard genetics professor and entrepreneur Church…. [W]hen Church describes current work building microbes with minimal genes, the book takes off – and eventually soars…. [A] stimulating book.”

Steven Pinker, Harvard College Professor of Psychology, Harvard University, and author of How the Mind Works and The Better Angels of Our Nature
“A thoughtful introduction to one of the great frontiers of science, one with the promise of literally saving the world. George Church is one of the most brilliant scientists in the world, and in collaboration with Ed Regis he has written a book that is engaging, readable, and thoroughly fascinating.”

J. Craig Venter, Chairman and President, J. Craig Venter Institute
“Church and Regis in Regenesis have written a wonderful synopsis of the emerging field of synthetic biology and the implications from renewable plastics to ‘raising the dead.’ This is a must-read for anyone interested in the future.”

Misha Angrist, Assistant Professor, Duke Institute for Genome Sciences & Policy, and author of Here is a Human Being
Regenesis is the most compelling bit of prophecy since the Old Testament first came out in hardback.”

About the Author

George Church is Professor of Genetics at the Harvard Medical School and member of the Wyss Institute of Biologically Inspired Engineering. He is the director of the Lipper Center for Computational Genetics, the Harvard DOE Genomes-to-Life Center, the NIH Center for Excellence in Genomic Science, and PersonalGenomes.org. Church was the driving force behind the Polonator G.007, a low-cost automated genomic sequencing machine. He lives in Brookline, Massachusetts. Ed Regis is author of seven science books, most recently "What Is Life?: Investigating the Nature of Life in the Age of Synthetic Biology." He lives in Sabillasville, Maryland.

More About the Author

George Church is Professor of Genetics at Harvard Medical School, Director of PersonalGenomes.org, providing the world's only open-access information on human genome & trait data. His 1984 Harvard PhD included the first direct genome sequencing, molecular multiplexing & barcoding. These lead to the first commercial genome sequence (pathogen, Helicobacter pylori) in 1994. His innovations in "next generation" genome sequencing & synthesis & cell/tissue engineering resulted in 12 companies including medical genomics (Knome, Alacris, AbVitro, GoodStart, Pathogenica) & synthetic biology (LS9, Joule, Gen9, Warp Drive) as well as new privacy, biosafety & biosecurity policies. Honors include election to NAS & NAE and Franklin Bower Laureate for Achievement in Science.

Customer Reviews

I read the book straight through as I do with books I like a lot.
S. Grose
If the proposals made in this book come to fruition in this century, they will have to rank as the most exciting in human history.
Dr. Lee D. Carlson
The science is incredible, and written in a way that is easy to understand while being completely informative.
Blair Todd

Most Helpful Customer Reviews

54 of 62 people found the following review helpful By Steve J. Sullivan on January 23, 2013
Format: Hardcover
A book outlining the future of sythetic biology and its implications is long overdue, but this book achieves neither. The examples given of synthetic biology are poorly described and tend to jump around (the very interesting chapter titles actually have no bearing on what is written and give the false impression that the book is structured). The authors spent very little time developing a cohesive philosophy about how our culture should approach this novel technology and instead resort to a "gee isn't that cool" kind of approach.

Overall, the book just seemed really fluffy. Many of the points made were repeated over and over without any depth. Instead, the authors fill pages by going into extensive detail about irrelevant matters, such as devoting several pages to describing the building where a convention on synthetic biology was hosted.

As a biology researcher, I can say this is definitely not for anyone with a background in science. Also, lay people looking for examples of synthetic biology should look elsewhere because this book does a poor job explaining things. Finally, those interested in the ethics of these issues will not find any interested arguments here on either side.
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27 of 30 people found the following review helpful By A. D. Thibeault on October 19, 2012
Format: Hardcover Verified Purchase
*A full executive summary of this book is available here: An Executive Summary of George M. Church and Ed Regis's 'Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves'

DNA was only discovered about a century ago, and its structure remained a mystery until about half a century ago, but since this time our knowledge and understanding of DNA has grown immensely (indeed exponentially). What's more, this understanding has evolved to include not just an understanding of how DNA works, but also how it can be manipulated to help advance our ends. The most glaring example here is the phenomenon of genetically modified food. Though not without controversy initially (and some fringe opposition that lives on to this day), it is fair to say that genetically modified food was one of the major scientific advances of the 20th century. Over and above this, our understanding of DNA appeared to reach its most impressive manifestation with the successful sequencing of the human genome in the year 2000.

For the genetics professor and pioneering genetic engineer George Church, however, genetically modified food and the Human Genome Project are but the tip of the iceberg when it comes to the potential of genomics. Indeed, since the year 2005, the exponential growth rate in our ability to read and write DNA has increased from 1.5-fold per year (a rate that matches Moore's law), to the incredible rate of 10-fold per year (p. 243). This explosion in scientific and technological progress has resulted in dramatic advancements in the areas of biochemicals, biomaterials, biofuels and biomedicine.
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16 of 19 people found the following review helpful By javajunki TOP 500 REVIEWER on October 10, 2012
Format: Hardcover Verified Purchase
I must agree with the above reviewer...this is an absolutely terrific book. Thanks to the superb review (and obvious enthusiasm) I opted to order this book on the spur of the moment while listening to a short interview with the author. Couldn't be more pleased. This book is absolutely fantastic. It's fun, it's downright frightening in some ways but it is fabulous across the board.

The author does a terrific job of making this somewhat complex topic accessible to the average reader. There are areas where I find myself wanting more information and a few areas of a bit less interest but overall, it presents a dramatic future view of the potential of synthetic biology including the promise and peril. Will it look exactly like this in the future...probably not but this gives great insight into the direction and trends rather than the specifics. Readers are likely to find at least a few things that are downright thrilling as well as some that are chilling to even contemplate. Clearly the legal limits haven't kept up with the emerging technology...an area that will need a lot of attention at some point in the future. Delightful book!
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32 of 41 people found the following review helpful By Tarpitboss on October 5, 2012
Format: Hardcover Verified Purchase
Regenesis, by George Church & Ed Regis is just published and... WOW! This read is super interesting, inspiring, fascinating and quite amazing. If there is a downside, the chemspeak is too dense in some places to make for easy, first time coherent reading BUT if you just power on straight ahead it all starts to sink in. We are heading on fast forward into territory that will change the future of humanity very fast indeed. Science fiction writers NEED to read this, write about the ideas to make them palatable for the film making community and general public so that the inevitable techno-shock waves are minimized. Share this one far and wide!
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6 of 7 people found the following review helpful By S. Grose on December 2, 2012
Format: Hardcover Verified Purchase
If you want to think things you've haven't thought before, read "Regenisis." I read the book straight through as I do with books I like a lot. Authors, Church and Regis form a good writing relationship. It seems like they might have equally participated in writing the book. The result is tight, readable prose, and understandable complex ideas, and most important to me, surprising ideas. I'll admit that where Church obviously wrote detailed explanations I didn't understand a lot of it, but Regis balanced out those spots. Regis is an awesome science writer. I imagine most readers who choose this book will understand the most detailed, most technical writing, however. Deciphering who wrote what most heavily was evident. Both wrote with passion and skill. I could not help but wonder where Church gets enough time to write a book like this, even with a co-writer. It's a book that is good from beginning to end, no soft spots in the middle.
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