I have tried everything from Proactive to antibiotics to many other internal and external remedies. Nothing has worked as well as Acnezine. It took a couple months before I saw a big improvement, but I have maintained a mostly clear complexion. I had acne on my back and chest and that has improved greatly. I still have an occasional breakout, but it doesn't last long and I don't have cysts like I used to. I was in middle school when I started having acne (I'm now 30)and nothing has helped it much until this past year. I've been on it for more than a year now and it's still continuing to work. There are no side effects and I prefer to use remedies that are more natural. I can't say it will work for everyone, but all I know is that nothing else has worked consistently and Acnezine has given me my confidence back. I'm so glad I discovered it!